Finally, I am appreciative of my partners and staff at Carolina Neurosurgery and Spine Associates (CNSA) and of the patients who trust us with their medical care. We strive to deliver the best possible neurosurgical care for our patients each and every day.
REFERENCES
part one
CHAPTER ONE: DIAGNOSIS
“Acute myeloid leukemia.” MedlinePlus. Accessed February 20, 2017. https://medlineplus.gov/acutemyeloidleukemia.html.
“Adult acute myeloid leukemia treatment (PDQ®)—Health professional version.” NIH National Cancer Institute. 2017. https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq.
“Adult acute myeloid leukemia treatment (PDQ®)—Patient version.” NIH National Cancer Institute. 2017. https://www.cancer.gov/types/leukemia/patient/adult-aml-treatment-pdq.
Harry, B. The Paul McCartney Encyclopedia. London: Virgin, 2002.
CHAPTER TWO: LEARNING TO TIE KNOTS/ARC OF A CAREER
Ferrara, Felicetto and Charles A Schiffer. “Acute Myeloid Leukaemia in Adults.” The Lancet 381, no. 9865 (2013): 484–95. https://doi.org/10.1016/s0140-6736(12)61727-9.
Quintás-Cardama, Alfonso, and Jorge E. Cortes. “Chronic Myeloid Leukemia: Diagnosis and Treatment.” Mayo Clinic Proceedings 81, no. 7 (2006): 973–88. https://doi.org/10.4065/81.7.973.
Singer, Robert J., Christopher S. Ogilvy, and Guy Rordorf. (2016) “Screening for intracranial aneurysm.” In J. Biller (Ed.), UpToDate, 2016. https://www.uptodate.com/contents/screening-for-intracranial-aneurysm.
part two
CHAPTER THREE: THE PATIENT’S PERSPECTIVE
Halt the development of malignancies:
Zilfou, J. T. and S. W. Lowe. “Tumor Suppressive Functions of p53.” Cold Spring Harbor Perspectives in Biology 1, no. 5 (2009). https://doi.org/10.1101/cshperspect.a001883.
Propensity to developing leukemia:
Tomasetti, C., L. Li, and B. Vogelstein. (2017). “Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.” Science, 355(6331), 1330–34. https://doi.org/10.1126/science.aaf9011.
ADDITIONAL SOURCES
“Adult acute myeloid leukemia treatment (PDQ®)—patient version.” NIH National Cancer Institute. (2017). https://www.cancer.gov/types/leukemia/patient/adult-aml-treatment-pdq.
“Bone marrow (stem cell) donation.” MedlinePlus. August 15, 2016. https://medlineplus.gov/ency/patientinstructions/000839.htm.
“BRCA1 & BRCA2: Cancer risk and genetic testing.” NIH National Cancer Institute. (2015). https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet.
Desouza, R. M., H. Shaweis, C. Han, V. Sivasubramiam, L. Brazil, R. Beaney, G. Sadler, S. Al-Sarraj, T. Hampton, and J. Logan. “Has the Survival of Patients with Glioblastoma Changed over the Years?” British Journal of Cancer 114, no. 2 (2015): 146–50. https://doi.org/10.1038/bjc.2015.421.
“Donate bone marrow.” Be the Match. April 22, 2016. https://bethematch.org/support-the-cause/donate-bone-marrow/.
“Donor resources.” Gift of Life. Accessed February 22, 2017. https://www.giftoflife.org/page/content/donorresources.
“Epigenomics (Fact Sheet).” National Human Genome Research Institute. (2016). https://www.genome.gov/27532724/Epigenomics-Fact-Sheet.
“Facts about Neupogen® (Filgrastim).” Centers for Disease Control and Prevention. April 16, 2016. https://emergency.cdc.gov/radiation/neupogenfacts.asp.
“Filgrastim, Filgrastim-sndz, Tbo-filgrastim Injection: MedlinePlus drug information.” MedlinePlus. February 7, 2017. https://medlineplus.gov/druginfo/meds/a692033.html.
“Genetic counseling for hereditary breast and ovarian cancer.” Centers for Disease Control and Prevention. (2014). https://www.cdc.gov/genomics/resources/diseases/breast_ovarian_cancer/counseling.htm.
“Glioblastoma (GBM).” American Brain Tumor Association. (2014). http://www.abta.org/brain-tumor-information/types-of-tumors/glioblastoma.html.
“High-dose chemotherapy and stem cell transplant for acute lymphocytic leukemia.” American Cancer Society. Accessed February 22, 2017. https://www.cancer.org/cancer/acute-lymphocytic-leukemia/treating/bone-marrow-stem-cell.html.
Mayo Clinic staff. “Blood and bone marrow donation.” May 30, 2014. http://www.mayoclinic.org/tests-procedures/bone-marrow/basics/definition/PRC-20020055?p=1.
Mirimanoff, René-Olivier, Thierry Gorlia, Warren Mason, Martin J. Van Den Bent, Rolf-Dieter Kortmann, Barbara Fisher, Michele Reni, Alba A. Brandes, Jüergen Curschmann, Salvador Villa, et al. “Radiotherapy and Temozolomide for Newly Diagnosed Glioblastoma: Recursive Partitioning Analysis of the EORTC 26981/22981-NCIC CE3 Phase III Randomized Trial.” Journal of Clinical Oncology 24, no. 16 (2006): 2563–69. https://doi.org/10.1200/jco.2005.04.5963.
Neergaard, Lauran. “Science says: Who and what is to blame for cancer?” U.S. News and World Report. March 23, 2017. https://www.usnews.com/news/news/articles/2017-03-23/science-says-who-and-what-is-to-blame-for-cancer.
Park, John K., Tiffany Hodges, Leopold Arko, Michael Shen, Donna Dello Iacono, Adrian Mcnabb, Nancy Olsen Bailey, Teri Nguyen Kreisl, Fabio M. Iwamoto, Joohee Sul, et al. “Scale to Predict Survival after Surgery for Recurrent Glioblastoma Multiforme.” Journal of Clinical Oncology 28, no. 24 (2010): 3838–43. https://doi.org/10.1200/jco.2010.30.0582.
Polivka, Jiri Jr., Jiri Polivka, Lubos Holubec, Tereza Kubikova, Vladimir Priban, Ondrej Hes, Kristyna Pivovarcikova, and Inka Treskova. “Advances in experimental targeted therapy and immunotherapy for patients with glioblastoma multiforme.” Anticancer Research, 37, no 1 (2017): 21–33. https://doi.org/10.21873/anticanres.11285.
Ray, Surabh, Machaon M. Bonafede, and Nimish A. Mohile. “Treatment patterns, survival, and healthcare costs of patients with malignant gliomas in a large US commercially insured population.” American Health & Drug Benefits, 7, no 3 (2014): 140–49.
Scott, Jacob G., Luc Bauchet, Tyler J. Fraum, Lakshmi Nayak, Anna R. Cooper, Samuel T. Chao, John H. Suh, Michael A. Vogelbaum, David M. Peereboom, Sonia Zouaoui, et al. “Recursive Partitioning Analysis of Prognostic Factors for Glioblastoma Patients Aged 70 Years or Older.” Cancer 118, no. 22 (2012): 5595–5600. https://doi.org/10.1002/cncr.27570.
Sekeres, Mikkael. When Blood Breaks Down: Life Lessons From Leukemia. Boston, MA: MIT Press, 2020.
Shah, Binay Kumar, Amir Bista, and Sandhya Sharma. “Survival Trends in Elderly Patients with Glioblastoma in the United States: a Population-Based Study.” Anticancer Research 36, no. 9 (2016): 4883–86. https://doi.org/10.21873/anticanres.11052.
“Stem cell transplant for acute myeloid leukemia.” American Cancer Society. Accessed February 22, 2017. https://www.cancer.org/cancer/acute-myeloid-leukemia/treating/bone-marrow-stem-cell-transplant.html.
Stone, J. “What you need to know on world bone marrow day.” Forbes. September 18, 2015. http://www.forbes.com/sites/judystone/2015/09/18/world-bone-marrow-donor-day-give-the-gift-of-life/.
Stupp, Roger, Monika E. Hegi, Warren P Mason, Martin J. Van Den Bent, Martin J B Taphoorn, Robert C. Janzer, Samuel K. Ludwin, Anouk Allgeier, Barbara Fisher, Karl Belanger, et al. “Effects of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy Alone on Survival in Glioblastoma in a Randomised Phase III Study: 5-Year Analysis of the EORTC-NCIC Trial.” The Lancet Oncology 10, no. 5 (2009): 459–66. https://doi.org/10.1016/s1470-2045(09)70025-7.
“Temozolomide injection.” MedlinePlus. February 15, 2013. https://medlineplus.gov/druginfo/meds/a613002.html.
“Temozolomide oral.” Medline Plus. January 15, 2016. https://medlineplus.gov/druginfo/meds/a601250.html.
Tomasetti, Cristian, Lu Li, and Bert Vogelstein. “Stem Cell Divisions, Somatic Mutations, Cancer Etiology, and Cancer Prevention.” Science 355, no. 6331 (2017): 1330–34. https://doi.org/10.1126/science.aaf9011.
Zilfou, J. T. and S. W. Lowe. “Tumor Suppressive Functions of p53.” Cold Spring Harbor Perspectives in Biology 1, no. 5 (2009). https://doi.org/10.1101/cshperspect.a001883.
CH
APTER FOUR: RECONNECTING/FIRST VISIT
Groopman, Jerome. “The Transformation: Is it possible to control cancer without killing it?” The New Yorker. September 15, 2014. http://www.newyorker.com/magazine/2014/09/15/transformation-3.
ADDITIONAL SOURCES
“About blood and marrow transplantation.” Memorial Sloan Kettering Cancer Center. Accessed March 9, 2017. https://www.mskcc.org/pediatrics/cancer-care/treatments/cancer-treatments/transplantation/about.
Ballen, Karen K. “Is There a Best Graft Source of Transplantation in Acute Myeloid Leukemia?” Best Practice & Research Clinical Haematology 28, no. 2-3 (2015): 147–54. https://doi.org/10.1016/j.beha.2015.10.012.
“Bone marrow transplantation.” MedlinePlus. January 12, 2017. https://medlineplus.gov/bonemarrowtransplantation.html.
Dykewicz, Clare A. “Hospital Infection Control in Hematopoietic Stem Cell Transplant Recipients.” Emerging Infectious Diseases, 7, no 2 (2001): 263–67. https://doi.org/10.3201/eid0702.700263.
Dykewicz, Clare A. “Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients.” Clinical Infectious Diseases 33, no. 2 (2001): 139–44. https://doi.org/10.1086/321805.
Gaballa, Sameh, Neil Palmisiano, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O’Hara, Margaret Kasner, Walter K. Kraft, Benjamin Leiby, Ubaldo Martinez-Outschoorn, William O’Hara, et al. “A Two-Step Haploidentical versus a Two-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation.” Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 22, no. 1 (2016): 141–48. https://doi.org/10.1016/j.bbmt.2015.09.017.
“Graft-versus-host disease.” Be the Match. November 30, 2016. https://bethematch.org/for-patients-and-families/life-after-transplant/graft-versus-host-disease--gvhd-/.
Grosso, Dolores, Sameh Gaballa, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O’Hara, Margaret Kasner, Ubaldo Martinez-Outschoorn, John L. Wagner, William O’Hara, Shannon Rudolph, et al. “A Two-Step Approach to Myeloablative Haploidentical Transplantation: Low Nonrelapse Mortality and High Survival Confirmed in Patients with Earlier Stage Disease.” Biology of Blood and Marrow Transplantation 21, no. 4 (2015): 646–52. https://doi.org/10.1016/j.bbmt.2014.12.019.
“Hand hygiene in healthcare settings.” Centers for Disease Control and Prevention. Accessed March 9, 2017. https://www.cdc.gov/handhygiene/.
“Handwashing videos—CDC.” Centers for Disease Control and Prevention. Accessed March 9, 2017. https://www.cdc.gov/handwashing/videos.html.
“Handwashing: Clean hands save lives.” Centers for Disease Control and Prevention. February 15, 2017. https://www.cdc.gov/handwashing/when-how-handwashing.html.
“Infection prevention.” Be the Match. December 23, 2014. https://bethematch.org/for-patients-and-families/life-after-transplant/staying-healthy/infection-prevention/
Isoyama, K., M. Oda, K. Kato, T. Nagamura-Inoue, S. Kai, H. Kigasawa, R. Kobayashi, J. Mimaya, M. Inoue, A. Kikuchi, et al. “Long-Term Outcome of Cord Blood Transplantation from Unrelated Donors as an Initial Transplantation Procedure for Children with AML in Japan.” Bone Marrow Transplantation 45, no. 1 (2009): 69–77. https://doi.org/10.1038/bmt.2009.93.
Rich, Ivan N. “Improving Quality and Potency Testing for Umbilical Cord Blood: A New Perspective.” STEM CELLS Translational Medicine 4, no. 9 (2015): 967–73. https://doi.org/10.5966/sctm.2015-0036.
Rosenberg, N.and R. R. Nelson. “American Universities and Technical Advance in Industry.” Research Policy, 23, no. 3 (1994): 323–48.
“StatBite AML Survival after Bone Marrow Transplant by Type of Donor.” JNCI Journal of the National Cancer Institute 103, no. 10 (2011): 783–83. https://doi.org/10.1093/jnci/djr179.
“Transplant Frequently Asked Questions.” US Department of Health and Human Services. Accessed March 9, 2017. https://bloodcell.transplant.hrsa.gov/transplant/understanding_tx/transplant_faqs/index.html.
“WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge: Clean Care Is Safer Care.” World Health Organization. 2010.
Young, Jo-Anne H., Brent R. Logan, Juan Wu, John R. Wingard, Daniel J. Weisdorf, Cathryn Mudrick, Kristin Knust, Mary M. Horowitz, Dennis L. Confer, Erik R. Dubberke, et al. “Infections after Transplantation of Bone Marrow or Peripheral Blood Stem Cells from Unrelated Donors.” Biology of Blood and Marrow Transplantation 22, no. 2 (2016): 359–70. https://doi.org/10.1016/j.bbmt.2015.09.013.
SEEKING CONTROL
A lawsuit that they won against Genentech:
Pollack, Andrew. “A Jury Orders Genentech to Pay $300 Million in Royalties,” New York Times, June 11, 2002. https://www.nytimes.com/2002/06/11/business/a-jury-orders-genentech-to-pay-300-million-in-royalties.html.
Receive related transplants:
Hede, K. “Half-Match Bone Marrow Transplants May Raise Odds for More Recipients.” JNCI Journal of the National Cancer Institute 103, no. 10 (2011): 781–83. https://doi.org/10.1093/jnci/djr181.
Large volumes of healthy stem cells:
Ballen, Karen K. “Is There a Best Graft Source of Transplantation in Acute Myeloid Leukemia?” Best Practice & Research Clinical Haematology 28, no. 2-3 (2015): 147–54. https://doi.org/10.1016/j.beha.2015.10.012.
See also: Gaballa, Sameh, Neil Palmisiano, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O’Hara, Margaret Kasner, Walter K. Kraft, Benjamin Leiby, Ubaldo Martinez-Outschoorn, William O’Hara et al. “A Two-Step Haploidentical versus a Two-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation.” Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 22, no1 (2016): 141–48. https://doi.org/10.1016/j.bbmt.2015.09.017
The absence of matched donors:
Isoyama, K., M. Oda, K. Kato, T. Nagamura-Inoue, S. Kai, H. Kigasawa, R. Kobayashi, J. Mimaya, M. Inoue, A. Kikuchi, et al. “Long-Term Outcome of Cord Blood Transplantation from Unrelated Donors as an Initial Transplantation Procedure for Children with AML in Japan.” Bone Marrow Transplantation 45, no. 1 (2009): 69–77. https://doi.org/10.1038/bmt.2009.93.
See also: Munoz, Javier, Nina Shah, Katayoun Rezvani, Chitra Hosing, Catherine M. Bollard, Betul Oran, Amanda Olson, Uday Popat, Jeffrey Molldrem, Ian K. Mcniece et al. “Concise Review: Umbilical Cord Blood Transplantation: Past, Present, and Future.” STEM CELLS Translational Medicine 3, no. 12 (2014): 1435–43.
Sanz, Jaime, Miguel A. Sanz, Silvana Saavedra, Ignacio Lorenzo, Pau Montesinos, Leonor Senent, Dolores Planelles, Luis Larrea, Guillermo Martín, Javier Palau et al. “Cord Blood Transplantation from Unrelated Donors in Adults with High-Risk Acute Myeloid Leukemia.” Biology of Blood and Marrow Transplantation 16, no. 1 (2010): 86–94.
Sato, A., J. Ooi, S. Takahashi, N. Tsukada, S. Kato, T. Kawakita, T. Yagyu, F. Nagamura, T. Iseki, A. Tojo, et al. “Unrelated Cord Blood Transplantation after Myeloablative Conditioning in Adults with Advanced Myelodysplastic Syndromes.” Bone Marrow Transplantation 46, no. 2 (2010): 257–61.
ADDITIONAL SOURCES
“City of Hope v. Genentech.” April 24, 2008. Stanford Law School, Robert Crown Library. http://scocal.stanford.edu/opinion/city-hope-v-genentech-33188.
Ciurea, Stefan O., Mei-Jie Zhang, Andrea A. Bacigalupo, Asad Bashey, Frederick R. Appelbaum, Omar S. Aljitawi, Philippe Armand, Joseph H. Antin, Junfang Chen, Steven M. Devine, et al. “Haploidentical Transplant with Posttransplant Cyclophosphamide vs. Matched Unrelated Donor Transplant for Acute Myeloid Leukemia.” Blood 126, no. 8 (2015): 1033–40. https://doi.org/10.1182/blood-2015-04-639831.
“Genentech reports 28 percent increase in product sales for second quarter.” Genentech. July 10, 2002. https://www.gene.com/media/press-releases/5227/2002-07-10/genentech-reports-28-percent-increase-in.
Haw, Jennie. “From Waste to (Fool’s) Gold: Promissory and Profit Values of Cord Blood.” Monash Bioethics Review 33, no. 4 (2015): 325–39. https://doi.org/10.1
007/s40592-015-0048-5.
Hede, K. “Half-Match Bone Marrow Transplants May Raise Odds for More Recipients.” JNCI Journal of the National Cancer Institute 103, no. 10 (2011): 781–83. https://doi.org/10.1093/jnci/djr181.
Matsumoto, Monica M. and Kirstin R. W. Matthews. “A Need for Renewed and Cohesive US Policy on Cord Blood Banking.” Stem Cell Reviews and Reports 11, no. 6 (2015): 789–97. https://doi.org/10.1007/s12015–015–9613–9.
Munoz, Javier, Nina Shah, Katayoun Rezvani, Chitra Hosing, Catherine M. Bollard, Betul Oran, Amanda Olson, Uday Popat, Jeffrey Molldrem, Ian K. Mcniece et al. “Concise Review: Umbilical Cord Blood Transplantation: Past, Present, and Future.” STEM CELLS Translational Medicine 3, no. 12 (2014): 1435–43. https://doi.org/10.5966/sctm.2014–0151.
Pollack, Andrew. “A Jury Orders Genentech to Pay $300 Million in Royalties,” New York Times, June 11, 2002. https://www.nytimes.com/2002/06/11/business/a-jury-orders-genentech-to-pay-300-million-in-royalties.html.
Sanz, Jaime, Miguel A. Sanz, Silvana Saavedra, Ignacio Lorenzo, Pau Montesinos, Leonor Senent, Dolores Planelles, Luis Larrea, Guillermo Martín, Javier Palau et al. “Cord Blood Transplantation from Unrelated Donors in Adults with High-Risk Acute Myeloid Leukemia.” Biology of Blood and Marrow Transplantation 16, no. 1 (2010): 86–94. https://doi.org/10.1016/j.bbmt.2009.09.001.
Grief Connects Us Page 28