by Dr. Josh Axe
18 Afef Bejaoui, Hedia Chaabane, Maroua Jemli, et al., “Essential Oil Composition and Antibacterial Activity of Origanum Vulgare Subsp. Glandulosum Desf. at Different Phenological Stages,” Journal of Medicinal Food 16 (December 2013): 1115–20.
19 Mehrnaz Nikhah Bodagh, Iradj Maleki, and Azita Hekmatdoost, “Ginger in Gastrointestinal Disorders: A Systematic Review of Clinical Trials,” Food Science and Nutrition 7 (January 2019): 96–108.
20 Christine M. Kaefer and John A. Milner, “The Role of Herbs and Spices in Cancer Prevention,” The Journal of Nutritional Biochemistry 19 (June 2008): 347–61.
21 Alan Jiang, “Health Benefits of Culinary Herbs and Spices,” Journal of AOAC International 102 (March 2019): 395–411.
22 Kiran S. Panickar, “Beneficial Effects of Herbs, Spices and Medicinal Plants on the Metabolic Syndrome, Brain and Cognitive Function,” Central Nervous System Agents in Medicinal Chemistry 13 (March 2013): 13–29.
23 Mendel Friedman from, “Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds,” Journal of Agricultural and Food Chemistry 19 (August 2015): 7108–23.
24 Ye Jin, Xue Meng, Zhidong Qiu, et al., “Anti-Tumor and Anti-Metastatic Roles of Cordycepin, One Bioactive Compound of Cordyceps militaris,” Saudi Journal of Biological Sciences 25 (July 2018): 991–95.
25 Alena G. Guggenheim, Kirsten M. Wright, and Heather L. Zwickey, “Immune Modulation Five Major Mushrooms: Application to Integrative Oncology,” Integrative Medicine 13 (February 2014): 32–44.
26 Golnoosh Torabian, Peter Valtchev, Qayyum Adil, and Fariba Dehghani, “Anti-Influenza Activity of Elderberry (Sambucus Nigra),” Journal of Functional Foods 54 (March 2019): 353–60.
27 Harunobu Amagase and Dwight M. Nance, “A Randomized, Double-Blind, Placebo-Controlled Clinical Study of the General Effects of a Standardized Lycium barbarum (Goji) Juice, GoChi,” Journal of Complementary and Alternative Medicine 14 (June 2008): 403–12.
28 Peter Bucheli, Qiutao Gao, Robert Redgwell, et al., Herbal Medicine: Biomolecular and Clinical Aspects, 2nd ed. (Boca Raton, FL: CRC Press/Taylor & Francis, 2011).
29 Memorial Sloan Kettering Cancer Center, “Triphala,” updated November 7, 2019. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/triphala
30 Albert Jacob, Manju Pandey, Sorabh Kapoor, Raghavan Saroja, “Effect of the Indian Gooseberry (Amla) on Serum Cholesterol Levels in Men Aged 35–55 Years,” European Journal of Clinical Nutrition 42 (November 1988): 939–44.
31 Biswas Gopa, Jagatkumar Bhatt, and Kovur G. Hemavathi, “A Comparative Clinical Study of Hypolipidemia Efficacy of Amla (Emblica officinalis) with 3-Hydroxy-3Methylglutaryl-Coenzyme-A Reductase Inhibitor Simvastatin,” Indian Journal of Pharmacology 44 (March–April 2012): 238–42.
32 Kerry S. Kuehl, Diane L. Elliot, Adriana E. Sleigh, and Jennifer L. Smith, “Efficacy of Tart Cherry Juice to Reduce Inflammation Biomarkers among Women with Inflammatory Osteoarthritis (OA),” Journal of Food Studies 1 (2012).
33 Hsin-Chia Hung, Kaumudi J. Joshipura, Rui Jiang, et al., “Fruit and Vegetable Intake and Risk of Major Chronic Disease,” Journal of the National Cancer Institute 96 (November 2004): 1577–84.
34 Patricia Matanjun, Suhaila Mohamed, Kharidah Muhammed, and Noordin Mohamed Mustapha, “Comparison of Cardiovascular Protective Effects of Tropical Seaweeds, Kappaphycus Alvarezii, Caulerpa Lentillifera, and Sargassum Plycystum, on High Cholesterol/High-Fat Diet in Rats,” Journal of Medicinal Food 13 (August 2010): 792–800.
35 Jee Ae Shim, Young Ae Son, Ji Min Park, and Mi Kyung Kim, “Effect of Chlorella Intake on Cadmium Metabolism in Rats,” Nutrition Research and Practice 3 (Spring 2009): 15–22.
36 Jung Hyun Kwak, Seung Han Baek, Yongje Woo, et al., “Beneficial Immunostimulatory Effect of Short-Term Chlorella Supplementation: Enhancement of Natural Killer Cell Activity and Early Inflammatory Response (Randomized, Double-Blinded, Placebo-Controlled Trial),” Nutrition Journal 11 (July 2012).
37 Toru Mizoguchi, Isao Takehara, Tohru Masuzawa, et al., “Nutrigenomic Studies of Effects of Chlorella on Subjects with High-Risk Factors for Lifestyle-Related Disease,” Journal of Medicinal Food 11 (September 2008): 395–404.
38 S. Sreelatha and R. Inbavalli, “Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of Coriandrum Sativum Leaf and Stem in Alloxan-Induced Diabetic Rats,” Journal of Food Science 77 (July 2012): T119–23.
39 Pascal J. Delaquis, Kareen Stanich, Benoit Girard, and G. Mazza, “Antimicrobial Activity of Individual and Mixed Fractions of Dill, Cilantro, Coriander, and Eucalyptus Essential Oils,” International Journal of Food Microbiology 74 (March 2002): 101–9.
40 Gil Bar-Sela, Miri Cohen, Eran Ben-Arye, and Ron Epelbaum, “The Medical Uses of Wheatgrass: Review of the Gap Between Basic and Clinical Applications,” Mini-Reviews in Medicinal Chemistry 15 (2015): 1002–10.
41 Sadaharu Miyazono, Tomoki Isayama, Francois C. Delori, and Clint L. Makino, “Vitamin A Activates Rhodopsin and Sensitizes it to Ultraviolet Light,” Visual Neuroscience 28 (November 2011): 485–97.
42 Balu Muthaiyah, Musthafa M. Essa, Moon Lee, et al., “Dietary Supplementation of Walnuts Improves Memory Deficits and Learning Skills in Transgenic Mouse Model of Alzheimer’s Disease,” Journal of Alzheimer’s Disease 42 (2014): 1397–405.
43 Shibu M. Poulose, Marshall G. Miller, and Barbara Shukitt-Hale, “Role of Walnuts in Maintaining Brain Health with Age,” Journal of Nutrition 144 (April 2014): 561S–66S.
44 Lee J. Wylie, James Kelly, Stephen J. Bailey, et al., “Beetroot Juice and Exercise: Pharmacodynamic and Dose-Response Relationships,” Journal of Applied Physiology 115 (May 2013): 325–36.
45 Daniel Collado Mateo, Francesco Pazzi, Francisco J. Dominguez Munoz, et al., “Ganoderma lucidum Improves Physical Fitness in Women with Fibromyalgia,” Nutricion Hospitalaria 32 (2015): 2126–35.
46 Majid Naghdi, Maryam Maghbool, Morteza Seifalah-Zade, et al., “Effects of Common Fig (Ficus carica) Leaf Extracts on Sperm Parameters and Testis of Mice Intoxicated with Formaldehyde,” Evidence-Based and Complementary Medicine (January 2016): 1–9.
47 Mark A. Reger, Samuel T. Henderson, Cathy Hale, et al., “Effects of Beta-Hydroxybutyrate on Cognition in Memory-Impaired Adults,” Neurobiological Aging 25 (March 2004): 311–14.
Chapter 6: The Healing Value of Herbs, Spices, and Mushrooms
1. Alena G. Guggenheim, Kirsten M. Wright, and Heather L. Zwickey, “Immune Modulation from Five Major Mushrooms: Application to Integrative Oncology,” Integrative Medicine 13 (February 2014): 32–44.
2. Yihuai Gao, Shufeng Zhou, Wenqi Jiang, et al., “Effects of Ganopoly (A Ganoderma Lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients,” Immunological Investigations 32 (August 2003): 201–15.
3. Yun Zhang, Zhi-chun Lin, Ying Hu, and Fu-zhe Wang, “Effect of Ganoderma Lucidum Capsules on T Lymphocyte Subsets in Football Players ‘Living High-Training Low,’” British Journal of Sports Medicine 42 (October 2008): 819–22.
4. Zichria Zakay-Rones, Erling Thom, T. Wollan, and J. Wadstein, “Randomized Study of the Efficacy and Safety of Oral Elderberry Extract in the Treatment of Influenza A and B Virus Infections,” The Journal of International Medical Research 32 (April 2004): 132–40.
5. Evelin Tiralongo, Shirley S. Wee, and Rodney A. Lea, “Elderberry Supplementation Reduces Cold Duration and Symptoms in Air Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial,” Nutrients 8 (April 2016).
6. Jorg Melzer, Reinhard Saller, Andreas Schapowal, and Reto Brignoli, “Systematic Review of Clinical Data with BNO-101 (Sinupret) in the Treatment of Sinusitis,” Forsch Komplementemed 13 (April 2006): 78–87.
7. Sachin A. Shah, Stephen Sander, C. Michael White, et al., “Evaluation of Echinacea for the Prevention and Treatment of the Common Cold: A Meta-Analysis,” The Lancet Infectious Diseases 7 (July 2007): 473–80.
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br /> 8. M. Jawad, R. Schoop, A. Suter, et al., “Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial,” Evidence-Based Complementary and Alternative Medicine (September 2012).
9. Karel Raus, Stephan Pleschka, Peter Klein, et al., “Effect of an Echinacea-Based Hot Drink Versus Oseltamivir in Influenza Treatment: A Randomized, Double-Blind, Double Dummy, Multicenter, Noninferiority Clinical Trial,” Current Therapeutic Research, Clinical and Experimental 77 (December 2015): 66–72.
10 R. C. Saxena, Ramlala Singh, P. Kumar, and S. C. Yadav, “A Randomized Double Blind Placebo Controlled Clinical Evaluation of Extract of Andrographis paniculata (KalmCold) in Patients with Uncomplicated Upper Respiratory Tract Infection,” Phytomedicine 17 (March 2010): 178–85.
11 Swati Gupta, K. P. Mishra, and Lilly Ganju, “Broad-Spectrum Antiviral Properties of Andrographis,” Archives of Virology 162 (March 2017): 611–23.
12 Kojo Agyemang, Lifeng Han, Erwei Liu, et al., “Recent Advances in Astragalus membranaceus Anti-Diabetic Research: Pharmacological Effects of Its Phytochemical Constituents,” Evidence Based Complementary and Alternative Medicine (November 2013).
13 Ping Liu, Haiping Zhao, and Yumin Luo, “Anti-Aging Implications of Astragalus membranaceus (Huangqi): A Well-Known Chinese Tonic,” Aging and Disease 8 (December 2017): 868–86.
14 Ibid.
15 Estelle Viljoen, Janicke Visser, Nelene Koen, and Alfred Musekiwa, “A Systematic Review and Meta-Analysis of the Effect and Safety of Ginger in the Treatment of Pregnancy-Associated Nausea and Vomiting,” Nutrition Journal 19 (March 2014): 13–20.
16 Julie L. Ryan, Charles E. Heckler, Joseph A. Roscoe, et al., “Ginger (Zingiber officinale) Reduces Acute Chemotherapy-Induced Nausea: A URCC CCOP Study of 576 Patients,” Supportive Care in Cancer 20 (July 2012): 1479–89.
17 Zhongzhi Wang, Junichi Hasegawa, Xinhui Wang, et al., “Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats,” Yonaga Acta Medica 54 (March 2011): 11–19.
18 Ming-Luen Hu, Christophan K. Rayner, Keng-Liang Wu, et al., “Effect of Ginger on Gastric Motility and Symptoms of Functional Dyspepsia,” World Journal of Gastroenterology 17 (January 2011): 105–10.
19 Vinay Rayudu and Akondi B. Raju, “Effect of Triphala on Dextran Sulphate Sodium-Induced Colitis in Rats,” Ayu 35 (July–September 2014): 333–38.
20 Nguyen Dinh Thang, Pham Ngoc Diep, Pham Thi-Huong Lien, and Le Thi Lien, “Polygonum multiflorum Root Extract as a Potential Candidate for Treatment of Early Graying Hair,” Journal of Advanced Pharmaceutical Technology and Research 8 (January–March 2017): 8–13.
21 Alexander Panossian and Georg Wikman, “Pharmacology of Schisandra chinensis Bail.: An Overview of Russian Research and Uses in Medicine,” Journal of Ethnopharmacology 118 (2008): 183–212.
22 Alexander Panossian and Georg Wikman, “Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular Mechanisms Related to Their Stress-Protective Activity,” Current Clinical Pharmacology 4 (September 2009): 198–219.
23 Sae Kwang Ku, Hyemee Kim, Joo Wan Kim, et al. “Ameliorating Effects of Herbal Formula Hemonine on Experimental Subacute Hemorrhagic Anemia in Rats,” Journal of Ethnopharmacology 198 (February 2017): 205–13.
24 Noel M. Arring, Denise Millstine, Lisa A. Marks, and Lillian M. Nail, “Ginseng as a Treatment for Fatigue: A Systematic Review,” Journal of Alternative and Complementary Medicine 24 (July 2018): 624–33.
25 Bao-qin Lin and Shao-ping Li, “Chapter 5: Cordyceps as an Herbal Drug,” Herbal Medicine: Biomolecular and Clinical Aspects, 2nd ed. (Boca Raton, Florida: CRC Press/Taylor & Francis, 2011).
26 Steve Chen, Zhaoping Li, Robert Krochmal, et al., “Effect of CS-4 (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial,” Journal of Alternative and Complementary Medicine 16 (May 2010): 585–90.
27 Federico Brandalise, Valentina Cesaroni, Andrej Gregori, et al., “Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice,” Evidence-Based Complementary and Alternative Medicine (January 2017).
28 Koichiro Mori, Satoshi Inatomi, Kenzi Ouchi, and Yoshihito Azumi, “Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A Double-Blind Placebo-Controlled Clinical Trial,” Phytotherapy Research 23 (March 2009): 367–72.
29 Hsing-Chun Kuo, Bruce Lu, Chien-Heng Shen, and Shui-Yi Tung, “Hericium erinaceus Myecelium and Its Isolated Erinacine a Protection from MPTP-Induced Neurotoxicity through the ER Stress, Triggering an Apoptosis Cascade,” Journal of Translational Medicine 18 (March 2016).
30 Con Stough, J. Lloyd, L. A. Downey, et al., “The Chronic Effects of an Extract of Bacopa Monniera (Brahmi) on Cognitive Function in Healthy Human Subjects,” Psychopharmacology 156 (August 2001): 481–84.
31 Chuenjid Kongkeaw, Piyameth Dilokthornsakul, Phurit Thanarangsarit, et al., “Meta-Analysis of Randomized Controlled Trials on Cognitive Effects of Bacopa monnieri Extract,” Journal of Ethnopharmacology 151 (November 2013): 528–35.
32 Marco Canevelli, Nawal Adali, Eirini Keaiditi, et al., “Effects of Ginkgo Biloba Supplementation in Alzheimer’s Disease Patients Receiving Cholinesterase Inhibitors: Data from the ICTUS Study,” Phytomedicine 15 (May 2014): 888–92.
33 Julia Berger, Beth Burgwyn Fuchs, George Aperis, et al., “Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay,” PLOS Pathogens 3 (February 2007): 3833–41.
34 Bin Shan, Yizhong Z. Cai, Mei Sun, and Harold Corke, “Antioxidant Capacity of 26 Spice Extracts and Characterization of Their Phenolic Constituents,” Journal of Agricultural and Food Chemistry 53 (September 2005): 747–59.
35 Gang-sheng Wang, Jie-hua Deng, Yao-hui Ma, et al., “Mechanisms, Clinically Curative Effects, and Antifungal Activities of Cinnamon Oil and Pogostemon Oil Complex against Three Species of Candida,” Journal of Traditional Chinese Medicine 32 (March 2012): 19–24.
36 Katey M. Lemar, Michael Patrick Turner, and David Lloyd, “Garlic (Allium sativum) as an Anti-Candida Agent: A Comparison of the Efficacy of Fresh Garlic and Freeze-Dried Extracts,” Journal of Applied Microbiology 93 (February 2002): 398–405.
37 Leyla Bayan, Peir Hossain Koulivand, and Ali Gorji, “Garlic: A Review of Potential Therapeutic Effects,” Avicenna Journal of Phytomedicine 4 (January–February 2014): 1–14.
38 Yasunari Takada, Anjana Bhardwaj, Pravin D. Potdar, and Bharat Aggarwal, “Nonsteroidal Anti-Inflammatory Agents Differ in Their Ability to Suppress NF-kappaB Activation, Inhibition of Expression of Cyclooxygenase-2 and Cyclin D1, and Abrogation of Tumor Cell Proliferation,” Oncogene 23 (January 2005): 9247–58.
39 Kaiping Wang, Peng Cao, Weizhi Shui, et al., “Angelica sinensis Polysaccharide Regulates Glucose and Lipid Metabolism Disorder in Prediabetic and Streptozotocin-Induced Diabetic Mice through the Elevation of Glycogen Levels and Reduction of Inflammatory Markers,” Food and Function 6 (March 2015): 902–9.
40 Adriene Fugh-Berman, “Herbs and Dietary Supplements in the Prevention and Treatment of Cardiovascular Disease,” Preventive Cardiology 3 (Winter 2000): 24–32.
41 Ernst-Gerhard Loch, Hartmut Selle, and Normann Boblitz, “Treatment of Premenstrual Syndrome with a Phytopharmaceutical Formulation Containing Vitex agnus castus,” Journal of Women’s Health and Gender-Based Medicine 9 (April 2000): 315–20.
42 Lynn M. Westphal, M. L. Polan, and A. Sontag Trant, “Double-Blind, Placebo-Controlled Study of Fertilityblend: A Nutritional Supplement for Improving Fertility in Women,” Clinical and Experimental Obstetrics and Gynecology 33 (January 2006): 205–8.
43 Elizabeth Steels, Amanda Rao, and Luis Vitetta, “Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation,” Phytotherapy Research 25 (February 2011): 1294–300.
44 Maryam Mehrpooya, Soghra
Rabiee, Amir Larki-Harchegani, et al., “A Comparative Study on the Effect of ‘Black Cohosh’ and ‘Evening Primrose Oil’ on Menopausal Hot Flashes,” Journal of Education and Health Promotion 7 (March 2018).
45 K. Jiang, Y. Jin, L. Huang, et al., “Black Cohosh Improves Objective Sleep in Postmenopausal Women with Sleep Disturbances,” Climacteric 18 (2015): 559–67.
46 Ludovico Abenavoli, Raffaele Capasso, Natasa Milic, and Frencesco Capasso, “Milk Thistle in Liver Diseases: Past, Present, Future,” Phytotherapy Research 24 (October 2010): 1423–32.
47 Erica S. Lovelace, Jessica Wagoner, James MacDonald, et al., “Silymarin Suppresses Cellular Inflammation by Inducing Reparative Stress Signaling,” Journal of Natural Products 78 (August 2015): 1990–2000.
48 Reneta Gevrenova, Magdalena Kondeva-Burdina, Nikolay Denkov, and Dimitrina Zheleva-Dimitrova, “Flavonoid Profiles of Three Bupleurum Species and In Vitro Hepatoprotective Activity of Bupleurum flavum Forsk,” Pharmacognosy Magazine 11 (January–March 2015): 14–23.
49 Liangliang Cai, Dongwei Wan, Fanglian Yi, and Libiao Luan, “Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root,” Molecules 22 (August 2017).
50 Olov Lindahl and Lars Lindwall, “Double Blind Study of Valerian Preparation,” Pharmacology Biochemistry and Behavior 32 (April 1989): 1065–66.
51 Simin Taavoni, Neda Ekbatani, Maryam Kashaniyan, and Hamid Haghani, “Effect of Valerian on Sleep Quality in Postmenopausal Women: A Randomized Placebo-Controlled Clinical Trial,” Menopause 18 (September 2011): 951–55.
52 John R. Keefe, Jun J. Mao, Irene Soeller, et al., “Short-Term Open-Label Chamomile (Matricaria chamomilla L.) Therapy of Moderate to Severe Generalized Anxiety Disorder,” Phytomedicine 23 (December 2015): 1699–705.
53 Scott Shannon, Nicole Lewis, Heather Lee, and Shannon Hughes, “Cannabidiol in Anxiety and Sleep: A Large Case Series,” Permanente Journal 23 (2019).