Shen, H., ‘Studies cast doubt on cancer drug as Alzheimer’s treatment’, Nature, 23 May 2013, online: www.nature.com/news/studies-cast-doubt-on-cancer-drug-as-alzheimer-s-treatment-1.13058
Shenk, D., The Forgetting: Alzheimer’s: Portrait of an Epidemic, Anchor Books, 2001
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M.,… St George-Hyslop, P. H., ‘Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease’, Nature, 375 (6534), 1995, 754–60
Siman, R., Shahim, P., Tegner, Y., Blennow, K., Zetterberg, H., Smith, D. H., ‘Serum SNTF increases in concussed professional ice hockey players and relates to the severity of postconcussion symptoms’, Journal of Neurotrauma, 32 (17), 2015, 1294–300
Singh, B., Parsaik, A. K., Mielke, M. M., Erwin, P. J., Knopman, D. S., Petersen, R. C., Roberts, R. O., ‘Association of Mediterranean diet with mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis’, Journal of Alzheimer’s Disease, 39 (2), 2014, 271–82
Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R.,… Wagers, A. J., ‘Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle’, Science, 344 (6184), 2014, 649–52
Small, G. W., Ercoli, L. M., Silverman, D. H., Huang, S. C., Komo, S., Bookheimer, S. Y.,… Phelps, M. E., ‘Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease’, Proceedings of the National Academy of Sciences of the United States of America, 97 (11), 2000, 6037–42
Smiley, J., The Sagas of the Icelanders, Penguin, 2005
Snowdon, D., Aging with Grace: The Nun Study and the Science of Old Age. How We Can All Live Longer, Healthier and More Vital Lives, Fourth Estate, 2011
Soldner, F., and Jaenisch, R., ‘iPSC disease modeling’, Science, 338 (6111), 2012, 1155–6
Solfrizzi, V., Panza, F., Frisardi, V., Seripa, D., Logroscino, G., Imbimbo, B. P., Pilotto, A., ‘Diet and Alzheimer’s disease risk factors or prevention: the current evidence’, Expert Reviews of Neurotherapeutics, 11 (5), 2011, 677–708
Sontag, S., Illness as Metaphor, Penguin, 1991
Spinney, L., ‘The forgetting gene’, Nature, 510 (7503), 2014, 26–8
Stadtfeld, M., and Hochedlinger, K., ‘Induced pluripotency: history, mechanisms, and applications’, Genes & Development, 24 (20), 2010, 2239–63
Stamps, J. J., Bartoshuk, L. M., Heilman, K. M., ‘A brief olfactory test for Alzheimer’s disease’, Journal of the Neurological Sciences, 333 (1–2), 2013, 19–24
Staropoli, J. F., ‘Tumorigenesis and neurodegeneration: two sides of the same coin?’, Bioessays, 30 (8), 2008, 719–27
Stein, G., Four in America, Yale University Press, 1947
Steinberg, M., Leoutsakos, J. M., Podewils, L. J., Lyketsos, C. G., ‘Evaluation of a home-based exercise program in the treatment of Alzheimer’s disease: the Maximizing Independence in Dementia (MIND) study’, International Journal of Geriatric Psychiatry, 24 (7), 2009, 680–5
Stern, Y., ‘What is cognitive reserve? Theory and research application of the reserve concept’, Journal of the International Neuropsychological Society, 8 (3), 2002, 448–60
Stossel, S., My Age of Anxiety, Windmill Books, 2014
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., Roses, A. D., ‘Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease’, Proceedings of the National Academy of Sciences of the United States of America, 90 (5), 1993, 1977–81
Summers, W. K., Majovski, L. V., Marsh, G. M., Tachiki, K. Kling, A., ‘Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer’s type’, New England Journal of Medicine, 315 (20), 1986, 1241–5
Summers, W. K., Viesselman, J. O., Marsh, G. M., Candelora, K., ‘Use of THA in treatment of Alzheimer’s-like dementia: pilot study in twelve patients’, Biological Psychiatry, 16 (2), 1981, 145–53
Swaab, D., We Are Our Brains: From the Womb to Alzheimer’s, Penguin, 2015
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., ‘Induction of pluripotent stem cells from adult human fibroblasts by defined factors’, Cell, 131 (5), 2007, 861–72
Takahashi, K., and Yamanaka, S., ‘Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors’, Cell, 126 (4), 2006, 663–76
Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y.,… Ming, G. L., ‘Zika virus infects human cortical neural progenitors and attenuates their growth’, Cell Stem Cell, 18 (5), 2016, 587–90
Tanzi, R. E., Decoding Darkness: The Search for the Genetic Causes of Alzheimer’s Disease, Perseus, 2001
, ‘A brief history of Alzheimer’s disease gene discovery’, Journal of Alzheimer’s Disease, 33 Suppl 1, 2013, S5–13
Tanzi, R. E., and Bertram, L., ‘Twenty years of the Alzheimer’s disease amyloid hypothesis: a genetic perspective’, Cell, 120 (4), 545–55
Tanzi, R. E., Gusella, J., Watkins, P. C., Bruns, G. A., St George-Hyslop, P., Van Keuren, M. L.,… Neve, R. L., ‘Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus’, Science, 235 (4791), 1987, 880–4
Taylor, B., The Last Asylum: A Memoir of Madness in Our Times, Penguin, 2015
Taylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C.,… Allsop, D., ‘Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer’s Aβ peptide’, Nanomedicine: Nanotechnology, Biology, and Medicine, 7 (5), 2011, 541–50
Terry, R. D., Gonatas, N. K., Weiss, M., ‘Ultrastructural studies in Alzheimer’s presenile dementia’, American Journal of Pathology, 44, 1964, 269–97
Thelma, B. K., Juyal, R. C., Dodge, H. H., Pandav, R., Chandra, V., Ganguli, M., ‘APOE polymorphism in a rural older population-based sample in India’, Human Biology, 73 (1), 2001, 135–44
Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., Jones, J. M., ‘Embryonic stem cell lines derived from human blastocysts’, Science, 282 (5391), 1998, 1145–7
UK Department of Health, ‘Dementia: A State of the Nation Report on Dementia Care and Support in England’, 29 November 2013
Underwood, E., ‘Alzheimer’s amyloid theory gets modest boost’, Science, 349 (6247), 2015, 464
Van Broeckhoven, C., Backhovens, H., Cruts, M., De Winter, G., Bruyland, M., Cras, P., Martin, J. J., ‘Mapping of a gene predisposing to early-onset Alzheimer’s disease to chromosome 14q24.3’, Nature Genetics, 2 (4), 1992, 335–9
Van de Winckel, A., Feys, H., De Weerdt, W., Dom, R., ‘Cognitive and behavioural effects of music-based exercises in patients with dementia’, Clinical Rehabilitation, 18 (3), 2004, 253–60
Van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O’Collins, V., Macleod, M. R., ‘Can animal models of disease reliably inform human studies?’, PLoS Medicine, 7 (3), 2010, e1000245
Vassar, R., ‘BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease’, Alzheimer’s Research and Therapy, 6 (9), 2014, 89
Verghese, A., The New York Times Book of Medicine: More Than 150 Years of Reporting on the Evolution of Medicine, Sterling, 2015
Verkhratsky, A., and Butt, A., Glial Neurobiology, John Wiley, 2007
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G.,… Wyss-Coray, T., ‘The ageing systemic milieu negatively regulates neurogenesis and cognitive function’, Nature, 477 (7362), 2011, 90–4
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J.,… Wyss-Coray, T.,‘Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice’, Nature Medicine, 20 (6), 2014, 659–63
Von Radowitz, J., ‘Vampire therapy: young blood may reverse ageing’, Independent, 4 May 20
14
Vonnegut, K., Cat’s Cradle, Penguin Classics, 2008
Wade, N., ‘Thomas S. Kuhn: Revolutionary Theorist of Science’, Science, 197 (4299), 1977, 143–5
Wang, S. S., ‘Alzheimer’s families clamor for drug’, Wall Street Journal, 11 February 2012
Warren, H. S., Tompkins, R. G., Moldawer, L. L., Seok, J., Xu, W., Mindrinos, M. N.,… Davis, R. W., ‘Mice are not men’, Proceedings of the National Academy of Sciences of the United States of America, 112 (4), 2015, E345
Watkins, C. C., and Treisman, G. J., ‘Cognitive impairment in patients with AIDS–prevalence and severity’, HIV AIDS, 7, 2015, 35–47
Watson, J., The Double Helix, Weidenfeld & Nicolson, 2011
Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., Kirschner, M. W., ‘A protein factor essential for microtubule assembly’, Proceedings of the National Academy of Sciences, 72 (5), 1975, 1858–62
Weissman, I. L., ‘The road ended up at stem cells’, Immunological Reviews, 185, 2002, 159–74
White, L., Petrovitch, H., Ross, G. W., Masaki, K. H., Abbott, R. D., Teng, E. L.,… Curb, J. D., ‘Prevalence of dementia in older Japanese-American men in Hawaii: the Honolulu-Asia Aging Study’, Journal of American Medical Association, 276 (12), 1996, 955–60
Whitlock, J. R., Sutherland, R. J., Witter, M. P., Moser, M. B., Moser, E. I., ‘Navigating from hippocampus to parietal cortex’, Proceedings of the National Academy of Sciences of the United States of America, 105 (39), 2009, 14755–62
Wilson, R. S., Arnold, S. E., Schneider, J. A., Kelly, J. F., Tang, Y., Bennett, D. A., ‘Chronic psychological distress and risk of Alzheimer’s disease in old age’, Neuroepidemiology, 27 (3), 2006, 143–53
Wilson, R. S., Barnes, L., Bennett, D. A., Li, Y., Bienias, J. L., Mendes de Leon, C. F., Evans, D. A., ‘Proneness to psychological distress and risk of Alzheimer disease in a biracial community’, Neurology, 64 (2), 2005, 380–2
Wilson, R. S., Evans, D. A., Bienias, J. L., Mendes de Leon, C. F., Schneider, J. A., Bennett, D. A., ‘Proneness to psychological distress is associated with risk of Alzheimer’s disease’, Neurology, 61 (11), 2003, 1479–85
Wilson, R. S., Mendes de Leon, C. F., Barnes, L. L., Schneider, J. A., Bienias, J. L., Evans, D. A., Bennett, D. A., ‘Participation in cognitively stimulating activities and risk of incident Alzheimer disease’, Journal of the American Medical Association, 287 (6), 2002, 742–8
Winblad, B., and Blum, K. I., ‘Hints of a therapeutic vaccine for Alzheimer’s?’, Neuron, 38 (4), 2003, 517–18
Wise, J., ‘Blood test can predict Alzheimer’s disease, say US scientists’, British Medical Journal, 348, 2014, g2074
Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L.,… Strydom, A., ‘A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome’, Nature Reviews Neuroscience, 16 (9), 2015, 564–74
Wolpert, L., Malignant Sadness: The Anatomy of Depression, Free Press, 2000
, How We Live and Why We Die: The Secret Lives of Cells, Faber & Faber, 2010
Wood, H., ‘Alzheimer disease: evidence for trans-synaptic and exo-synaptic tau propagation in Alzheimer disease’, Nature Reviews Neurology, 11 (12), 2015, 665
World Health Organization (WHO), ‘Dementia: Fact Sheet’, April 2016
Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., Weissman, I. L., ‘Physiological migration of hematopoietic stem and progenitor cells’, Science, 294 (5548), 2001, 1933–6
Yaffe, K. D., Vittinghoff, E., Lindquist, K., Barnes, D., Covinsky, K., Neylan, T.,… Marmar, C., ‘Post-traumatic stress disorder and risk of dementia among U.S. veterans’, Archives of General Psychiatry, 67 (6), 2010, 608–13
Yaguez, L., Shaw, K. N., Morris, R., Matthews, D., ‘The effects on cognitive functions of a movement-based intervention in patients with Alzheimer’s type dementia: a pilot study’, International Journal of Geriatric Psychiatry, 26 (2), 2011, 173–81
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S.,… Cole, G. M., ‘Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo’, Journal of Biological Chemistry, 280 (7), 2005, 5892–901
Yang, J., Li, S., He, X. B., Cheng, C., Le, W., ‘Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy’, Molecular Neurodegeneration, 11 (1), 2016, 39
Zetterberg, H., and Blennow, K., ‘Cerebrospinal fluid biomarkers for Alzheimer’s disease: more to come?’, Journal of Alzheimer’s Disease, 33 Suppl 1, 2013, S361–9
Zissimopoulos, J., Crimmins, E., St Clair, P., ‘The value of delaying Alzheimer’s disease onset’, Forum for Health Economics and Policy, 18 (1), 2014, 25–39
Zlokovic, B. V., ‘The blood-brain barrier in health and chronic neuro-degenerative disorders’, Neuron, 57 (2), 2008, 178–201
About the Author
Joseph Jebelli is a British neuroscientist and writer. He began to work on Alzheimer’s disease—specifically, using the body’s immune system to halt its progress—while studying for his PhD in neurobiology at University College London. He has written for The Guardian, The Telegraph and the Wellcome Trust. This is his first book.
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In Pursuit of Memory Page 29