“Three cats is hardly a statistically significant sample. Let’s wait until the other cats are tested. I understand that the group at the Pasteur Institute is doing the same tests, and we should hear from them in a day or two.”
“You’re right, of course. I guess I’m a bit anxious.”
“Aren’t we all? Incidentally, I don’t see the point of keeping the kittens in the cages any longer. Either they are resistant to FHF, or they aren’t. What’s the point of continuing to protect them?”
“Yes, you’re right, in a sense. However, I want to keep them secluded until they’re old enough to immunize with the routine agents such as panleukopenia and calicivirus. It would be a terrible joke if we succeeded in protecting the cats against FHF with the bullet, only to have them die of some ordinary virus for which we have vaccines.”
Noah wiped Lilith’s mouth for the tenth time. “Hadn’t thought of that.”
The next day, Angelo sent Noah and Vera an e-mail summarizing the progress at the CDC, the Pasteur Institute, and the Moscow Veterinary Institute. Vera read aloud to Kal and Jane from her computer screen. “Four kittens have been delivered to date at the CDC. All are healthy.”
“Hey, that’s great!” Kal declared.
Vera read on. “Six kittens so far in Paris, but one died during delivery. André Fidèle suspects a congenital defect of some sort. The Moscow Veterinary Institute has five healthy kittens.”
“Well,” Jane remarked, “it’s a start.”
Over the next month, all the queens gave birth to their kittens. All were viable, except a few that had died during birthing—one at the institute and two at the CDC. In Paris, one of the queens died during parturition, and the three fetuses she was carrying were lost. All the kittens at the Moscow Institute for Veterinary Medicine had survived and were thriving. By November 18, there was a total of eighty-seven kittens housed in all four labs.
On Monday, November 22, Vera was sitting in Noah’s office when his computer signaled a new e-mail. “It’s from Angelo,” Noah announced. He read the message aloud:
Noah and Vera
I have heard from André Fidèle at L’Institute Pasteur regarding their tests for incorporation of the FeLV-FHF vector into DNA of the kittens. He reports that of the 33 kittens surviving so far, 27 test positive for the vector. Of these, twelve are males and the rest are females.
Congratulations!
Now only one question remains. Will the incorporated vector protect the kittens against FHF?
Angelo
Noah looked up at Vera, and she at him. Her eyes became glazed. “Hold me!”
“Don’t cry,” Noah whispered. “I feel the same way. This is what we hoped for … It’s great news.”
“Just one tear?”
Noah pulled away to see she sported a big grin.
“Obviously, both sexes are equally likely to incorporate the bullet,” Vera noted.
By the end of November, technicians in the four labs had learned that, of the eighty-seven surviving kittens, twenty had not acquired the bullet genes. Those that had were about equally divided between males and females. Although the search went on for additional feral cats, no more were found in North America. A few were found in Norway, and five in North Africa, but all were already dying from FHF.
“It looks like we got started on this enterprise just in time,” muttered Vera one morning while scanning the newspaper.
“What?” called Noah from the kitchen.
“I said, I think we began the work with the feral cats just in time. They’re not finding any more uninfected cats anywhere.”
Noah came out of the kitchen. “None at all? Nowhere on earth? Unbelievable!”
Vera took a deep breath. “When I read stuff like this, I’m petrified,” she said. “Sixty-seven kittens on this planet capable of ensuring the survival of the species. Sixty-seven! I wonder what kind of odds the population biologists are giving Felis catus for survival. Of course, we don’t even know if the bullet will work.”
“I read a blog the other day on that very topic. Sixty-seven is right on the edge of the critical size for a population of small mammals to survive. Fortunately, the feral parents were acquired from different areas, and, therefore, have different gene mixes. We’ll have heterogeneity on our side. Also, there’s no doubt that these cats are going to receive the best possible care, and that will help ensure their survival.”
“Always assuming of course,” added Vera, “that the bullet actually protects them against FHF.”
“Well, yes, I have to assume that. If the four populations of cats survive, it will be important to get them interbreeding as soon as we can in order to keep the gene pool as varied as possible.”
Vera nodded. “Yes. I think we should start planning for that right away.”
“Whoa! Don’t you think we should wait until the big challenge?”
Vera stifled a sob. She rose and wrapped her arms around Noah. “I’ve got to believe that the bullet will be effective,” she said softly.
“Yes. Yes, of course.” Noah said nothing for a time. Finally, he asked, “When do you think we can expose the kittens to FHF?”
Vera thought a moment. “Well, first we’ve got to immunize the kittens against the other routine viruses. I figure we can start that on the oldest of the kittens in late December.”
“Sheesh. That’s a month off!”
“Uh huh. We’ll just have to take it easy until then.”
The day after Christmas, Vera immunized the kittens in the first batch, nine in all, against those feline viruses for which she had vaccines. She excluded FeLV, however, as this was the vector they had used to get the FHF genes into the fertilized eggs.
By the first week in January, all the kittens had received their shots. “Time to hurry up and wait,” muttered Vera.
“How long before we can let the cats out of the lab?” asked Noah.
Vera closed her eyes and rubbed her forehead with one hand. “I think we should wait at least a month for the vaccines to take effect, then we can let the cats out of the bag, so to speak. I understand that the other labs are planning to wait that long.”
“Whew! If patience is a virtue, we qualify as saints.”
On Valentine’s Day, the first three kittens had been weaned, and Vera announced that it was time to release them to the outside world. There was no fanfare, no press—no formal ceremony of any kind.
“Let’s do it,” she said to Noah and Kal.
“Of course, we’re probably putting Adam to his death,” Noah pointed out.
“I know. I know,” Vera responded. “That’s the point, isn’t it? Adam lacks the bullet. Eve and Naomi have it. If Adam dies and the other two live, we’ll know the experiment was successful.”
“They should be separated,” Noah said. “We could take one home …”
“Yes,” Vera agreed, “it will be a great playmate for Lilith. Besides, there should be plenty of FHF around from when Bastette had the virus. I’ll take one to the clinic. We know that the place is full of FHF, so that’ll be a good exposure. Kal, could you take the third home with you?”
“Sure. I used to have a cat before …” He shrugged. “Which kitten goes where?”
Noah said, “Let’s randomize the decision.” He grabbed a pocket calculator. “I’ll generate a random number from one to three. One is for Adam, two is for Eve, and three is for Naomi. Then I’ll do the same thing again for the chosen kitten’s destination. Okay?”
Vera and Kal nodded. Noah punched a few keys. “Adam goes with Kal,” he pronounced, “Eve comes home with us, and Naomi gets to reside at the clinic.”
Vera scooped up the two females and placed them in carriers. At the clinic, she decided not to house Naomi in a cage, but would let the kitten enjoy the run of the place. There was no point in protecting Naomi from FHF; she was
either protected, or she was going to die anyway. After she prepared a soft bed of clean rags near the litter box, Vera grabbed a few cans of cat food left from a time when there were feline patients at the clinic.
When she arrived home with Eve, she put the pet carrier on the floor and opened its door. The kitten looked out with fearful eyes. Cringing, she then edged to the back of the carrier. Vera reached in, picked her up, and held her close to her chest.
“Doris,” she called, “would you bring Lilith in here please?”
The nanny came in, cradling Lilith in her arms.
“Oh! Oh my goodness,” she exclaimed, “I never thought I’d see a living cat again!”
Vera smiled. “With luck, in time, there may be many more. Well, here goes. Set Lilith down on the floor, please.”
Doris did so, propping up the infant with a few pillows. Vera put the kitten down in front of her daughter. Lilith’s eyes opened wide. She reached out toward the cat and started giggling.
Vera grinned. “Well, well,” she said, “I guess this is going to work out.” She put the kitten closer to her baby and placed one of Lilith’s hands on her back. Vera then moved the child’s hands back and forth in a stroking motion. Lilith’s giggle broke into a hearty laugh. Eve purred loudly.
A few days later, Angelo arranged a teleconference among scientists working out of the four labs caring for bullet cats.
“We have two options,” declared Angelo. “We can begin releasing kittens to the public right away, or we can keep them sequestered until they are old enough to breed. Then we will be able to release the kittens from the next generation.”
André Fidèle said, “I don’t see any reason to wait. The cats are either resistant to FHF, or they are not. If they are, then there is no reason not to release them right away. I think we would be wise to get the new generation as geographically spread out as possible.”
“I don’t agree,” countered Vera. “At this stage of the program, there are still very few cats. They are precious. If something were to happen to even a few of them, this could reduce the breeding population below the critical size necessary to perpetuate the species. It is … or was common, before FHF, for cats to be run over by cars, or to be mauled by dogs or to die from infections. I feel strongly that we should breed the cats ourselves and only release them when we have, say, a couple of hundred worldwide.”
“Yes,” offered Professor Yuri Mishkin from Moscow, “Dr. Barnett is right. We must protect the first few generations until we are absolutely certain that the animals are resistant to FHF and that their numbers are over the hump, as the Americans say.”
“Ah, oui,” replied Fidèle, “I see that you two have a compelling argument.”
“That’s convincing,” Angelo agreed. “Then we must set up breeding programs in each of our centers.”
That evening, Kal was entertaining a lady friend named Karen, who was delighted with the kitten dozing in a corner of the sofa. “What’s her name?” she asked.
Kal replied, “It’s a he. His name is Adam.”
“I think this is the first cat I’ve seen in a year. Do you really think the cats from the university will make it?”
Kal sat down beside Karen, handing her a bottle of Hefweizen. “We hope that many will, but I don’t think Adam will be one of the survivors.”
“Why?” Karen put down her drink. “Is he sick? He looks okay.”
“I’m sorry. I didn’t mean to upset you. It’s just that Adam is kind of an experimental control. He didn’t get the protective genes that are supposed to guard the cats against the FHF virus. I expect he’ll start to show signs of the disease within a few days.”
“Oh, that is so sad.” She took the kitten in her lap and began stroking it tenderly. Adam, eyes still closed, purred. “Maybe you’re wrong. Maybe he’ll survive anyway.” Kal said nothing.
The next day, as expected, Adam was unsteady on his feet and would take no food. The kitten expired eighteen hours later.
In the months that followed, Vera and Noah kept in ongoing communication with the centers in Atlanta, Paris, and Moscow. “Look,” said Vera, pointing to the image on her laptop, “they’re building special enclosures at the CDC.” Noah peered over her shoulder. “Angelo says the compounds are large enough to accommodate up to a hundred cats each.” She scrolled down.
“Whoa!” cried Noah as he read aloud. “The cats are sealed off from the public by concrete block walls. Spectators can observe the colonies through thick, double-paned windows.”
Vera stood and put her arms around Noah. “There is so much effort, so much expense going into this. What if it’s all for nothing?”
Noah pulled back. “Vera, c’mon! We’ve done all we can. Our ideas are sound. As far as we know, we’ve made no mistakes. It’s up to nature—God, if you prefer.”
Vera stared into his eyes without speaking. Finally, with a raspy voice, “Right.” She pushed away. “Thank goodness we don’t have to worry about protecting the cats from FHF.”
By October, there were fifty-eight surviving sexually mature cats housed in the four centers. Those lacking the bullet had been removed from the colonies and died soon after. A few of the remaining animals had expired from causes unrelated to FHF.
Vera paced the room, Lilith in her arms. “It’s time, Noah. Starting today we can let the cats mate. “
Noah looked up from his reading. “I know. Think about it. Half the human population knows.”
Vera stopped pacing. She nodded, her face beaming. “Thank you. I’m so absorbed in the project, I guess I forget that much of the world is following it too … Oh Noah, I’m so scared.”
Noah rose and enfolded mother and daughter. The three remained still for several minutes.
Vera placed Lilith in her playpen. “We haven’t forgotten anything, have we?”
Noah wrinkled his brow. “Like what?”
Vera sat down beside him; she took his hand in hers. “Let’s go over it one more time,” she said. “In order to keep the gene pool as diversified as possible, we’ll ship several of our cats of each sex to Atlanta for breeding. Likewise, cats from the CDC will be flown to the institute.”
“Right. And the same exchange will be done with bullet cats from Paris and Moscow.
“I’m sorry, Noah. I keep expecting something to go wrong …”
“Vera! I’m the nervous Nellie, here. One of us has to be calm. You’re appointed.”
“Thank you,” she whispered. “Maybe we can both relax.” She kissed him warmly.
In November, just before Thanksgiving, Vera was checking her inbox. “Look, Noah, we got a break. Angelo writes that the mated females in all four labs are fertile. They’re all pregnant.” She yelled out, “Whoopee!”
Lilith began bawling. Noah picked up his daughter. “It’s all right, sweetheart. That’s just your mommy when she’s incredibly excited.”
By the end of the year, queens in Camarillo, Atlanta, and the two European cities were giving birth to litters of three or four second-generation bullet kittens.
In mid-March, Vera and Noah received an e-mail from Angelo, reporting that the French, and Russian groups had begun releasing cats from the labs.
In Paris, kittens were given to individual families. Le Monde, in cooperation with the Pasteur Institute, conducted an essay contest. In five hundred words or fewer, the writers had to explain why they wanted to care for one of the experimental cats. Three scientists from the institute, as well as several university professors, artists, and political personages served as judges. The winners each received a kitten provided, they could demonstrate they knew how care for the animal.
“We need to discuss this,” Vera remarked after she read Angelo’s message. How are we going to distribute the rest of the Camarillo kittens?”
“We could contact The Star,” said Noah. “I’ll bet that editor, K
ohut, would love to get in on it.”
Vera nodded. “Good idea. I don’t want to have a contest like the French are doing, however. Reading essays would take too much time. Nevertheless, we do have to be sure that whoever takes a kitten knows how to care for it.”
Vera phoned Douglas Kohut. As expected, he was pleased to have The Star help with distributing the cats. The next day on the front page, The Star announced a lottery. Winners would be given one of the kittens to take care of. Entrants had to demonstrate that they had the physical and financial means to take care of a cat. They were also warned that there was no guarantee that the pet would survive. An entry slip was printed right on the page. A drawing would be held for every kitten that was ready to be taken out of the lab. Within a week, the paper had received over four thousand entry slips, some from as far away as San Francisco.
By the following Tuesday, Vera was ready to release the first of the newly weaned kittens: two males and two females. The drawing was held at The Star’s offices in Camarillo. Several hundred people had gathered for the event. A huge, wire-mesh drum held the entry slips. Mayor Yoshino was on hand to officiate. He turned a large crank to rotate it, and picked out the first winner.
The mayor read from the slip. “Lorena Menendez of Oxnard.” He waited. No one came forward. “I guess she’s not present. It’s okay. Being here isn’t a requirement. We’ll phone her later.”
Douglas Kohut stepped forward. “Here, we can call her right now on my phone.” He dialed and, after a moment, handed the phone to the Mayor.
“Hello,” said Yoshino, “is this Lorena Menendez?” He looked at the crowd. “I think it’s her daughter. She’s going to get her mother.” A moment later he said, “Hello, Mrs. Menendez? Are you the Lorena Menendez who entered the drawing for a kitten?” He nodded vigorously toward the gathering. “I’m happy to tell you that you are the first winner.” He addressed the people in front of him. “She seems to be rather excited.” Back into the phone he added, “I’m going to let Dr. Barnett talk to you. She’ll arrange how you can pick up the kitten.” He handed the phone to Vera.
World without Cats Page 26