Why We Eat (Too Much)
Page 32
A recent independent meta-analysis of all the previous studies that looked at the relationship between saturated fats in the diet and the risk of death failed to show any increased risk, in particular no increased risk of developing heart disease, having a stroke or developing diabetes.11
Statins undoubtedly work in some cases, but I suspect that the rationale for prescribing them – high LDL and only slightly elevated total cholesterol levels – means that they are over-prescribed. The research certainly suits the pharmaceutical companies which produce the statins, but why are some medical associations (like the AHA) ignoring valid scientific research? What is the benefit for them? I will leave you to decide. Unfortunately, the perpetuation of the diet–heart hypothesis in the face of contradictory research means that dietary guidelines are stuck with the recommendation to avoid saturated fats from natural foods and to replace them with grains and artificial oils. Without these issues being addressed, our populations will still be guided to consume an obesogenic diet – and obesity will remain a major public health problem.
APPENDIX 2
Glycaemic Load and Omega-3 to Omega-6 Ratio of Common Foods
Source: Data courtesy of USDA National Nutrient Database for Standard Reference Nutrition Data; https://nutritiondata.self.com.
Notes on Appendix 2
Natural omega 3:6 ratio of diet is 1:1 to 1:4.
Most Western diets have omega 3:6 ratio of 1:15 or more.
Aim to reduce your omega 3:6 ratio towards natural levels.
The glycaemic load of foods is dependent on portion size; i.e. 1 large baked potato = glycaemic load 29, 2 large baked potatoes = glycaemic load 58.
Step 5 of the plan encourages starting with a daily glycaemic load maximum of 100, then slowly reducing this to a daily load of 80, or lower if this is comfortable. Remember, when replacing carb-heavy foods do not avoid natural foods that contain saturated fats, such as meat and dairy products. Also, remember most vegetables have a low glycaemic load and a good omega profile.
References
1 Metabology for Beginners
1 USDH (1998). Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. National Institute of Health (NIH) Publication, No. 98-4083, September.
2 R. Bailey (2018). Evaluating Calorie Intake for Population Statistical Estimates (ECLIPSE) Project, February. Office for National Statistics, Data Science Campus.
3 P. Miller (2015). The United States food supply is not consistent with dietary guidance: evidence from an evaluation using the Healthy Eating Index-2010. J Acad Nutr Diet, 115(1), January, 95–100.
4 J. Speakerman (2004). The functional significance of individual variation in basal metabolic rate. Physiol Biochem Zool, 77(6), 900–915.
5 G. Koepp (2016). Chair-based fidgeting and energy expenditure. BMJ Open Sport Exerc Med, 2(1).
6 E. Sims and E. Horton (1968). Endocrine and metabolic adaptation to obesity and starvation. Am J Clin Nutr, 21(12), December, 1455–70.
7 R. Leibel et al. (2000). Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Am J Clin Nutr, 71(6), June, 1421–32.
8 A. Harris et al. (2006). Weekly changes in basal metabolic rate with eight weeks of overfeeding. Obesity (Silver Spring), 14(4), April, 690–95.
9 C. Weyer et al. (2001). Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians. Int J Obes Relat Metab Disord, 25(5), May, 593–600.
10 A. Keys et al. (1950). The Biology of Human Starvation, Vol. 1. Minneapolis, University of Minnesota Press.
11 R. Leibel et al. (1995). Changes in energy expenditure resulting from altered body weight. N Eng J Med, 332(10), March, 621–8; S. Roberts and I. Rosenberg (2006). Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol Rev, 86(2), April, 651–67.
12 A. Evans et al. (2016). Drivers of hibernation in the brown bear. Frontiers in Zoology, 13, February, article no. 7.
13 R. Keesey (1997). Body weight set-points: determination and adjustment. J Nutr, 127(9), September, 1875S–1883S.
2 The Sacred Cow
1 B. Levin et al. (1989). Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol Regul Integr, 256 (3, Pt 2), R766–71.
2 M. Butovskaya et al. (2017). Waist-to-hip ratio, body-mass index, age and number of children in seven traditional societies. Sci Rep, 7(1), May, 1622.
3 M. Ashwell et al. (2014). Waist-to-height ratio is more predictive of years of life lost than body mass index. PLoS One, 9(9), September.
4 V. Eshed et al. (2010). Paleopathology and the origin of agriculture in the Levant. Am J Phys Anthropol, 143(1), September, 121–33.
5 World Health Organization (2016). Global Health Observatory Data.
6 J. Wardle and D. Boniface (2008). Changes in the distributions of body mass index and waist circumference in English adults, 1993/1994 to 2002/2003. Int J Obes (Lond), 32(3), March, 527–32.
7 Reuters/Ipsos (2012). Ipsos online poll of 1,143 adults, 7–10 May. Reuters.
8 C. Haworth et al. (2008). Childhood obesity: genetic and environmental overlap with normal-range BMI. Obesity, 16(7), July, 1585–90.
9 Q. Xia and S. F. Grant (2013). The genetics of human obesity. Ann N Y Acad Sci, 1281, April, 178–90.
10 B. Gascoigne (2001). Retrieved 2018, from HistoryWorld: www.historyworld.net.
11 J. Terrell (ed.) (1988). Von den Steinen’s Marquesan Myths, translated by Marta Langridge. Canberra: Target Oceania/Journal of Pacific History.
12 R. O’Rourke (2015). Metabolic thrift and the genetic basis of human obesity. Ann Surg, 259(4), April, 642–8.
13 J. Neel (1962). Diabetes mellitus: a ‘thrifty’ genotype rendered detrimental by ‘progress’? Am J Hum Genet, 14, December, 353–62.
14 World Health Organization (2016). Global Health Observatory Data.
15 P. Manning (1992). ‘The Slave Trade: The Formal Demography of a Global System’, in J. E. Inikori and S. L. Engerman (eds), The Atlantic Slave Trade. Durham, NC: Duke University Press.
16 A. Quasim et al. (2018). On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations. Obes Rev, 19(2), February, 121–49.
17 Y. Wang and M. Beydoun (2007). The obesity epidemic in the United States – gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev, 29, 6–28; Centers for Disease Control and Prevention (CDC) (2012). National Health and Nutrition Examination Survey, NHANES 2011–2012 Overview. National Center for Health Statistics.
18 S. van Dijk et al. (2015). Epigenetics and human obesity. Int J Obes, 39(1), 85–97.
19 Z. Stein and M. Susser (1975). The Dutch famine, 1944–1945, and the reproductive process. I. Effects on six indices at birth, Pediatric Research, 9, February 70–76.
20 M. Hult et al. (2010). Hypertension, diabetes and overweight: looming legacies of the Biafran famine. PLoS One, 5(10), October, e13582.
21 B. Weinhold (2006). Epigenetics: the science of change. Environ Health Perspect, 114(3), March, A160–A167.
22 I. Ehrenreich and D. Pfennig (2016). Genetic assimilation: a review of its potential proximate causes and evolutionary consequences. Ann Bot, 117(5), April, 769–79.
23 A. Samuelsson et al. (2008). Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension, 51(2), February, 383–92.
24 A. Kubo et al. (2014). Maternal hyperglycemia during pregnancy predicts adiposity of the offspring. Diabetes Care, 37(11), November, 2996–3002.
25 A. Sharma et al. (2005). The association between pregnancy weight gain and childhood overweight is modified by mother’s pre-pregnancy BMI. Pediatr Res, 58, 1038.
26 F. Guenard et al. (201
3). Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc Natl Acad Sci USA, 110(28), July, 11439–44.
27 R. Waterland and R. Jirtle (2003). Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol, 23(15), August, 5293–300.
28 Waterland and Jirtle (2003). Transposable elements.
3 Dieting and the Biggest Losers
1 E. Fothergill et al. (2016). Persistent metabolic adaptation for 6 years after ‘The Biggest Loser’ competition. Obesity (Silver Spring), 24(8), August, 1612–19.
2 H. Yoo et al. (2010). Difference of body compositional changes according to the presence of weight cycling in a community-based weight control program. J Korean Med Sci, 25(1), January, 49–53.
3 S. Dankel et al. (2014). Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. Am J Physiol Endocrinol Metab, 306(2), January, E210–24.
4 J. Speakerman et al. (2004). The functional significance of individual variation in basal metabolic rate. Physiol Biochem Zool, 77(6), November–December, 900–915.
5 L. Arone et al. (1995). Autonomic nervous system activity in weight gain and weight loss. Am J Physiol, 269(1, Pt 2), R222–5.
6 K. O’Dea et al. (1982). Noradrenaline turnover during under- and over-eating in normal weight subjects. Metabolism, 31(9), September, 896–9; S. Welle et al. (1991). Reduced metabolic rate during beta-adrenergic blockade in humans. Metabolism, 40(6), June, 619–22; A. Thorp and M. Schlaich (2015). Relevance of sympathetic nervous system activation in obesity and metabolic syndrome. J Diabetes Res, 2015, 341583.
7 J. Grundlingh et al. (2011). 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. J Med Toxicol, 7(3), September, 205–12.
4 Why We Eat
1 D. Cummings et al. (2002). Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Eng J Med, 346(21), May, 1623–30.
2 P. Sumithran et al. (2011). Long-term persistence of hormonal adaptations to weight loss. N Eng J Med, 365(17), October, 1597–1604.
3 J. Cirello and J. Moreau (2013). Systemic administration of leptin potentiates the response of neurons in the nucleus of the solitary tract to chemoreceptor activation in the rat. Neuroscience, 229, January, 89–99.
4 Y. Zhang et al. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372(6505), December, 425–32.
5 C. Montague et al. (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature, 387(6636), June, 903–8.
6 S. Heymsfield et al. (1999). Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA, 282(16), October, 1568–75.
5 The Glutton
1 F. Chehab (2014). 20 years of leptin: leptin and reproduction: past milestones, present undertakings, and future endeavours. J Endocrinol, 223(1), October, T37–48.
2 Chehab (2014). 20 years of leptin.
3 R. Lustig (2013). Fat Chance: Beating the odds against sugar, processed food, obesity and disease. New York: Hudson Street Press.
4 S. Ramirez and M. Claret (2015). Hypothalamic ER stress: a bridge between leptin resistance and obesity. FEBS Lett, 589(14), June, 1678–87.
5 R. Lustig et al. (2004). Obesity, leptin resistance and the effects of insulin reduction. Int J Obes Relat Metab Discord, 28(10), October, 1344–8.
6 B. Wisse and M. Schwartz (2009). Does hypothalamic inflammation cause obesity? Cell Metab, 10(4), October, 241–2.
7 I. Nieto-Vazquez et al. (2008). Insulin resistance associated to obesity: the link TNF-alpha. Arch Physiol Biochem, 114(3), July, 183–94.
8 Chehab (2014). 20 years of leptin.
9 J. Wang et al. (2001). Overfeeding rapidly induces leptin and insulin resistance. Diabetes, 50(12), December, 2786–91.
7 The Master Chef
1 R. Dawkins (1989). The Selfish Gene, 2nd edn. Oxford: Oxford University Press.
2 L. C. Aiello and P. Wheeler (1995). The expensive-tissue hypothesis: the brain and the digestive system in human and primate evolution. Current Anthropology, 36(2), April, 199–221.
3 F. Berna et al. (2012). Microstratigraphic evidence of in situ fire in the Acheulean strata of Wonderwerk Cave, Northern Cape province, South Africa. PNAS, 109(20), May, E1215–20.
4 C. Koebnick et al. (1999). Consequences of a long-term raw food diet on body weight and menstruation: results of a questionnaire survey. Ann Nutr Metab, 43(2), 69–79.
5 I. Olalde et al. (2014). Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature, 507(7491), March, 225–8.
6 D. Bramble and D. Lieberman (2004). Endurance running and the evolution of Homo. Nature, 432 (7015), November, 345–52.
7 P. Williams (2007). Nutritional composition of red meat. Nutrition and Dietetics, 64(4), August, 113–19.
8 P. Clayton (2009). How the mid-Victorians worked, ate and died. Int J Environ Res Public Health, 6(3), March, 1235–53.
8 The Heart of the Matter
1 US Department of Agriculture Economic Research Service – Food Availability; Statistical Abstract of the United States. US Government Printing Office, 763.
2 J. Yudkin (1972). Pure, White and Deadly: How sugar is killing us and what we can do to stop it. London: Davis-Poynter; reissue London: Penguin Books, 2012.
3 R. McGandy et al. (1967). Dietary fats, carbohydrates and atherosclerotic vascular disease. N Eng J Med, 277(4), July, 186–92.
4 C. Kearns (2016). Sugar industry and coronary heart disease research: a historical analysis of internal industry documents. JAMA Intern Med, 176(11), November, 1680–85.
5 A. Keys (1980). Seven Countries: A multivariate analysis of death and coronary heart disease. Cambridge, MA: Harvard University Press.
6 Keys (1980). Seven Countries.
7 N. Teicholz (2014). The Big Fat Surprise: Why butter, meat and cheese belong in a healthy diet. New York: Simon & Schuster.
8 R. H. Lustig (2013). Fat Chance: The hidden truth about sugar, obesity and disease. London: Fourth Estate.
9 Teicholz (2014). The Big Fat Surprise, p. 101.
10 E. Steele et al. (2016). Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study. BMJ Open, 6(3), March.
11 P. Clayton (2009). How the mid-Victorians worked, ate and died. Int J Environ Res Public Health, 6(3), March, 1235–53; J. E. Bennett et al. (2015). The future of life expectancy and life expectancy inequalities in England and Wales: Bayesian spatiotemporal forecasting. The Lancet, 386(9989), July, 163–70.
9 The Omega Code
1 D. Arnold (2010). British India and the ‘Beriberi Problem’, 1798–1942. Med Hist, 54(3), July, 295–314.
2 A. Hawk (2006). The great disease enemy, Kak’ke (beriberi) and the Imperial Japanese Army. Military Medicine, 171(4), 333–9.
3 N. Raizman (2004). Review of S. R. Bown, Scurvy: How a Surgeon, a Mariner, and a Gentleman Solved the Greatest Medical Mystery of the Age of Sail (New York: St Martin’s Press, 2003). J Clin Invest, 114(12), December, 1690.
4 J. Lind (1753). A Treatise of the Scurvy. Edinburgh: A. Kincaid and A. Donaldson.
5S. Allport (2006). The Queen of Fats. Berkeley, CA: University of California Press.
6 C. E. Ramsden et al. (2013). Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ, 346, February, e8707.
7 A. P. Simopoulos (2004). Omega-6/omega-3 essential fatty acid ratio and chronic diseases. Food Reviews International, 20(1), 77–90.
8 H. Freitas et al. (2017). Polyunsaturated fatty acids and endocannabinoids in health and disease. Nutr Neurosci, 21(1), July, 1–20.
9 A. P. Simopoulos (2016). An increase in the omega-6/omega-3 fatty acid
ratio increases the risk for obesity. Nutrients, 8(3), March, 128.
10 S. Banni and V. Di Marzo (2010). Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. Mol Nutr Food Res, 54(1), January, 82–92; I. Matias and V. Di Marzo (2007). Endocannabinoids and the control of energy balance. Trends Endocrinol. Metab, 18(1), January–February, 27–37.
11 Allport (2006). The Queen of Fats.
12 A. Evans (2016). Drivers of hibernation in the brown bear. Frontiers in Zoology, 13, February, article no. 7.
13 T. Ruf and W. Arnold (2008). Effects of polyunsaturated fatty acids on hibernation and torpor: a review and hypothesis. Am J Physiol Regul Integr Comp Physiol, 294(3), March, R1044–52; D. Munro and D. W. Thomas (2004). The role of polyunsaturated fatty acids in the expression of torpor by mammals: a review. Zoology, 107(1), 29–48.
14 G. L. Florant (1998). Lipid metabolism in hibernators: the importance of essential fatty acids. Amer Zool, 38, 331–40.
15 V. Hill and G. L. Florant (2000). The effect of a linseed oil diet on hibernation in yellow-bellied marmots (Marmota flaviventris). Physiol Behav, 68(4), February, 431–7.
16 Allport (2006). The Queen of Fats.
10 The Sugar Roller Coaster
1 P. Evans and R. Lynch (2003). Insulin as a drug of abuse in body building. Br J Sports Med, 37(4), August, 356–7.
2 R. Henry et al. (1993). Intensive conventional insulin therapy for type II diabetes. Metabolic effects during a 6-mo outpatient trial. Diabetes Care, 16(1), January, 21–31.