by John Ringo
“As you might have heard on the news, the kid who figured out dual expression has been ‘cooperating’ with the CDC,” Curry said. “I’ll take an agnostic position on whether he has anything to do, directly, with the virus. He’s being helpful, he was just in a video conference with the WHO and others and not only pointed out some helpful stuff but a possible… Call it an ameliorative. Not a cure but something that might help. Again, might. Thing is he’s a little too pat or I’m a little too cynical. Doesn’t matter. The first news, well ahead of the news as it were, is potassium may inhibit the secondary neurological packet’s expression. Sort of. Bottomline is we all might want to start taking potassium supplements. Which people can OD on by the way. Too much potassium will kill you as dead as too much. But as long as the dosage isn’t too high, I’d recommend them.”
“That’s good news,” Bateman said, looking at Tom.
“I’ll get that promulgated through our medical personnel,” Tom said, composing a note on his iPhone.
“Then we get to vaccine,” Dr. Curry said. “Turns out this is one hell of a virus. I’m not going to totally bio geek out but not only does it express two viruses with one packet, it expresses two viruses so different they’re night and day. Just to give you the short version: Influenza is a DNA virus. It has a full DNA packet and is a fairly complicated virus. The neurological, blood-pathogen, packet is an RNA virus. RNA is, sort of, half of a DNA strand. And RNA viruses are so different from DNA viruses there are some pretty good theories that they come from two entirely different evolutionary processes. They might as well be alien lifeforms to each other. And, somehow, the mad bastard who created this thing got both to express from a single pathogen. Brilliant. And very problematic for the vaccine.
“The CDC, Hong Kong and Pasteur have all produced detailed directions for their experimental vaccines. You don’t want them yet. They are really experimental. Like ‘trial and error’ experimental. With lots of error. They’ve already mapped out a vaccine for the airborne packet. But producing influenza vaccine is…complicated. And it takes time. And I can’t do it in this lab even if we had the design. What I can do, if it works out, is the blood pathogen vaccine. Once they work out the bugs.”
“What are the differences?” Bateman asked. “And what are the risks?”
“Well the risks right now are high,” Curry said, chuckling. “They had some of their lab rats catch the bug. Which is the ‘error’ part. But they’ll work it out. Then the real problems come. However…I’m going to have to explain how this vaccine is going to be made, in general. Cause I’m going to need some more equipment.”
“Which is?” Bateman asked. “I thought you had everything you needed?”
“I have everything you’d have in a regular laboratory,” Curry said, nodding. “For its size, even a well equipped one. What I don’t have is what you’d use to produce a vaccine. For that I’m going to have to lecture. Ahem… Vaccination One-Oh-One:
“Various ways of innoculating people against smallpox date back to ancient China and India. But the way they did it was pretty damned dangerous and was just as likely to give you the disease. There’s lots of bits in the middle but Edward Jenner figured out a way to use cowpox to vaccinate and that was what really started modern vaccine methods.
“It was Louis Pasteur that figured out that there were ways to ‘weaken’ pathogens, what’s called ‘attenuation’ and then use those weakened pathogens as a vaccine. The first one was a mistake with chicken cholera but it lead to all his other successful vaccines. The way he did it, exactly, isn’t important because it’s been superseded by other methods. Modern vaccines are produced in a number of ways. Very few of them use attenuation any more. But it’s still the fastest way to make vaccine. And they’re pretty sure that this pathogen can be prevented with an attenuation vaccine.”
“Why did they stop using it?” Bateman asked.
“Problems,” Dr. Curry said, waggling his hand from side to side. “Issues. Lawsuits. Immunology One-Oh-One. Your immune system’s a lot more complex than it’s explained in high school but the basics work for this. Antibodies identify pathogens and bind to them. That signals other immunobodies to attack and destroy them. However, the antibodies are originally produced because immune cells have detected that there are pathogens in the body. So you’ve got to be infected, first. And if you’ve got a good immune system and all’s well, you shake it off after a bit. If you don’t have a good immune system or the pathogen’s really nasty, well, you die.
“So…an attenuated vaccine is damaged bits of a pathogen. Just enough to tell the body ‘hey, you’ve got an infection! And it looks like this!’ without actually infecting you. The…issues are two-fold. More. The first is that if the vaccine isn’t strong enough your body doesn’t get a good enough look at the pathogen and when you do get hit with it you’re not really prepared. And then you die. Or, the vaccine is too strong, has too much of the pathogen left, and you get the disease and you die. Or you’re allergic to the materials in vaccine and you die. Or get really sick. Or there’s a scare story on TV. Or people blame their child’s autism on vaccines. Or…whatever. And in all those cases lawyers get involved and there’s a big lawsuit…”
“Which of those do we have to worry about?” Bateman asked.
“I dunno,” Curry said, shrugging. “Is Dr. Depene getting the vaccine? There’s a guy with so many risk factors, medical and psychological, the answer is all of them.”
“Thanks so much,” Depene said.
“If the recipe is right and I’m making the vaccine… There’s still a small risk that someone may get the disease instead of be protected from it. Half a percent? And to do it I need a radiation generator. That’s the big difference between Pasteur vaccines and modern attenuated. You can be much more precise in your attenuation, not to mention take less time, with irradiation…”
“Well no wonder nobody trusts it!” Depene said. “You’re not going to inject radioactive vaccine in me!”
“As I said,” Dr. Curry said, shaking his head. “Psychological risk factor, which, in and of itself, can cause hypocondriatic reactions. The vaccine isn’t radioactive, you dope. You shoot it with radiation which goes right through. It kills the RNA of the virus. There’s no residual radiation. What I’ll be using, to give you an example, is a dentist’s X-ray machine. Ever had your teeth X-rayed? One of the newer cesium source models is more or less vital. Which you’d better get your hands on fast or they’ll be all snatched up by the time you go shopping.”
“And this will work as a vaccine?” Bateman asked.
“Against the neurological packet,” Curry said, nodding. “It should. The other problem is that it’s going to take nearly two weeks to be close to ‘sure.’ Not ‘this is EPA approved and has been through all testing.’ Sure as in ‘This probably won’t kill you and probably will stop the disease.’ That’s the real problem. To get either one distributed will require all sorts of approvals. And then there’s…other problems. But once it’s through the most basic checks, I’ll start producing. And I’ll be the first one to take it, for what that’s worth to Dr. Depene. Oh, and it’s going to take a primer shot and a booster and you won’t really be covered until you’ve had the booster. And you can’t have the booster until a week after you’ve had the primer. So… We’re fighting the clock, the spread of the disease and the development and production of the vaccine. It’s going to be close. For us. For the world? I don’t give us a shot in hell.”
“Is there anything else critical?” Bateman asked.
“Not that you can’t get on the TV,” Curry said. “But you need to get that X-ray machine. And it will require some installation. Radiation shielding among other things. But that’s details I can go over with Mr. Smith. Until the vaccine is somewhat cleared, we’re in a holding pattern.”
“Very well,” Bateman said, nodding. “Thank you, again, for your assistance in this, Dr. Curry.”
“Just make sure the check clears,” Cu
rry said, chuckling.
“Break this down,” Bateman said.
CHAPTER 7
“The Center for Disease Control and the World Health Organization are assembling an unprecedented group of both professional and amateur synthetic biologists in a desperate search for a cure to the ongoing pandemic…”
“The FBI is searching for a white or Hispanic male in his early twenties believed to have last been seen in the Miami area in regards to the deliberate spread of the Pacific Flu Virus…”
“With the Pacific Flu wide-spread throughout the Pacific Rim, science reporter Timothy Karl has this report on Chinese authorities battle against this deadly disease…”
“Finally some good news as the World Health Organization last night reported a breakthrough in curing the Pacific Flu pandemic…”
“Any idea what he wants?” Bateman asked. All that he knew was that Curry had asked for a meeting. Given that the WHO had announced a “breakthrough” in vaccine yesterday, he’d been expecting the call earlier.
“No, sir,” Tom said. He’d called Curry last night as soon as he got the word. Curry had been tight-lipped and just asked for a meeting the following afternoon.
“Dr. Curry,” Bateman said into the screen. “Still holed up I see.”
“Yes, sir,” Curry said, licking his lips.
“We’re all agog on how you’re going to save us,” Bateman said. “I’d expected the call earlier.”
“Are we secure, Mr. Smith?” Curry said, temporizing.
“We are,” Tom said, curiously. “It’s only the three of us.”
“I’ll have to trust that,” Curry said nervously. “When I covered all the stuff about attenuation in the previous meeting there was a reason: The WHO was kind of ahead of itself on announcing a vaccine.”
“So you can’t make a vaccine?” Bateman said, sitting back, his face hard. “That’s not good news.”
“Just…” Curry said. “Let me get there. There is a vaccine. It’s just a matter of a sort of big logistics issue. The primary vaccine method has been known the whole time. We can do a flu vaccine, given time, in our sleep. But the flu, itself, is besides the point at this point. We need a vaccine for the secondary expressor. We could build a protein sequence mimicking the binding sites for that. They’re working on it. And it will take another two months, minimum. Then there’s certifications.”
“Doctor, we don’t have two months,” Tom said. “I’m not sure we have two weeks at the rate this is spreading.”
“I’m getting there…” Curry said.
“I need an answer, Doctor,” Bateman said.
“You want me to take this slow,” Curry said. “The secondary expressor turns out to be a lot like rabies. It’s definitely based upon it. About thirty percent of the same RNA, similar protein coat… It infects nerve cells. Primarily central nervous system. The spinal cord and brain. That’s…where you find the…face it the zombie virus.”
“Understood,” Bateman said. “And the attenuation vaccine. I think you mentioned lab rats. We got you quite a few. I suppose we can find some of the virus…” he said, looking at Smith.
“I’m sure…” Tom started to say.
“I asked for them assuming that I could work with them,” Curry said, grimacing. “They’re…basically just eating up rat food. Although you should probably get some rabbits or monkeys to use as cover… The thing is… Pasteur and CDC have both confirmed that this pathogen only affects higher order primates. That’s the only source of the virus bodies to attenuate.”
“Oh,” Tom said, leaning back and his face closing down. “Oh…bloody hell.”
“Higher…order…primates…” Bateman said, slowly and carefully. “That includes…?”
“Various…monkeys if you will,” Dr. Curry said, gulping. “Rhesus monkeys would do. Green monkeys possibly. Rhesus definitely. Possibly chimps. Probably chimps… The problem being, the supply of those is already being eaten up by the government for critical personnel. Has been eaten up. Critical personnel and research. There’s just none… None available. That was what I was checking. Thus the logistics problem.”
“Of course, homo sapiens is a higher order primate,” Tom said, his face hard and cold.
“And…yes,” Curry said. “Homo sapiens would… Yes, we are.”
“Thank you for that information, Dr. Curry,” Bateman said. “Besides attenuable virii, what do you need to make vaccine?”
“It’s been a week, sir,” Curry said. “Everything is installed and ready to go. As soon as I can get some virus bodies I can start cranking out the vaccine.”
“Understood,” Bateman said. “And, again, thank you for your assistance in this time of difficulty.”
“Thank you,” Curry said, closing the connection.
“Now I understand his insistence that this conversation was secure,” Bateman said. “And it never occurred.”
“Yes, sir,” Tom said.
“Dr. Curry needs some materials to produce the vaccine, Mr. Smith,” Bateman said, standing up. “I’ll detail a significant budget for this. Are there any questions?”
“No, sir,” Tom said, standing up. “I’ll take care of it, sir.”
* * *
“You understand that this never happened,” Tom said, suiting up.
Although he’d been told he’d never have to “take care” of something, he’d also been hired for his proven ability to plan ahead. And part of planning ahead was making sure that he had back-up in case his bosses were wrong.
Jim “Kapman” Kaplan and Dave “Gravy” Durante were part of that planning.
The term was “functional sociopath.” Both were former special operations. Both had combat experience. Both enjoyed combat. People, other than those close to them, weren’t really “real.”
Tom understood the mindset. He had the same type of brain. It was almost required to be in elite military units. It didn’t mean any of them were serial killers. He’d had them go through advanced poly tests to ensure that they weren’t going to be an “issue” as employees of the bank. They’d never done so much as assault that wasn’t under controlling legal authority. They kept their killer side under control by tight discipline. They just had the potential. In fact, they just really needed a good reason. Like, say, fighting terrorism. Or saving their bosses and family from a disease.
“Your bonus is one out of fifty doses,” Tom said, putting on the gloves of the Hazmat suit. The warehouse was a nondescript property in Alphabet Soup that the bank had reposessed. It was ostensibly untenanted. Setting up the “lab” for this mission had been easy enough. “We get vaccinated right after Dr. Curry. Curry, us, Dr. Bateman and then down. You can use the doses for anyone you want and you get two seats on the evacuation plan.”
“Understood, sir,” Kaplan said, pulling on his own gloves and holstering the taser. “Although I can actually see some value to this. Better than NYPD’s answer.”
The “Afflicted Temporary Holding Facilities” had already made the news. And the term “hell hole” was generally used.
“I’d rather be turned into vaccine than put in that place,” Durante said, holstering a back-up sidearm in case the taser didn’t do the trick. “And since we’re bonding, that’s my official answer. If I go full zombie, make me into vaccine.”
“Will do,” Tom said, getting an odd sensation. It took him a moment to recognize it. It was the feeling of coming home. This, really, was where he was designed by nature to be. In a team on the sharp end. “Same here.”
“All for one and all that,” Kaplan said, grinning through his mask. “I’m in. Strip my spine and put my head on a shelf.”
“I’ll do that for you, Kap,” Durante said, mock sobbing. “I’ll put your head on my mantelpiece and toast you once a year on the anniversary of you becoming a zombie. I swear, man!”
“Let’s load up,” Tom said, opening the door of the Heavy Emergency Response Vehicle. “Before you Yanks start kissing and stuff.”
&nbs
p; They rolled out of the warehouse and down Avenue B, maneuvering carefully through the traffic. The one positive to the disaster was that traffic was getting lighter and lighter as people found anywhere but New York to exist. Everybody knew that no matter what the government was saying, things were getting bad and getting bad fast.
They didn’t even get to Houston Street before they had their first customer.
* * *
Corinda was cursing her choice of delis for lunch and blessing her decision to wear walking shoes. If she’d been in heels the zombie would already have caught her. Unfortunately, it seemed to be in better shape than she was and was obsessive in chasing one Corinda Carfora, wildcat marketer. She’d been running nearly two block and it wasn’t even swerving for other pedestrians. She’d turned the corner for God’s sake!
And, being New York, nobody was so much as giving a second glance to a naked man chasing a woman down the street. Much less helping.
“You’re passing fatter people you idiot!” she screamed, giving a glance over her shoulder. Still there. This was ridiculous. The other mercy was that lunchtime walking traffic was light in Alphabet City so she didn’t have to dodge much. But she was wearing out. “Look! That guy! He’s fat! Eat him!”
Never a cop…
That hoary adage was belied when she was half way down the first block of B Avenue. A big black truck marked “Biological Emergency Response Team” swerved into traffic with blue lights on and stopped, blocking half of north-bound to a blare of horns.
Puffing, she swerved towards it as a pair of men in moon-suits and masks exited. One of them waved for her to pass between them as they both pulled out guns. She recognized that one was holding a taser. The other was a gun-gun. Bang you’re dead gun.
“Thank you,” she panted as she passed between them. “Thank you. Thank you…”
* * *
Tom waved the woman between them and took up a position covering Durante. Kaplan was driving and prepared to move out as soon as the zombie was tagged and bagged.