The Equations of Life

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The Equations of Life Page 38

by Charles S. Cockell


  But what about the emergence: However, for a persuasive view that even multicellularity could emerge through the operation of simple physical principles (and may therefore be inevitable), see Newman SA, Forgacs G, Müller GB. (2006) Before programs: The physical origination of multicellular forms. International Journal of Developmental Biology 50, 289–299.

  Although we cannot easily repeat evolution: We can, of course, find vestigial organs and genetic signposts that might reveal contingency and past history at work in fashioning an organism. We might also compare past evolutionary pathways up to an extinction event with those that occur afterward. For example, we might look at the evolution of the reptiles and compare them with the evolution of mammals after the end-Cretaceous. However, these are not controlled experiments in rerunning the sequence of evolution, since the environment has also changed, making it difficult, maybe impossible, to truly determine what is contingent and what is a consequence of altered conditions in which the organisms have been molded. We can more easily run evolutionary experiments in the laboratory and in certain well-controlled field settings to probe the role of contingency. For an excellent summary of research, from lizards to guppies and microbes, I recommend Losos J. (2017) Improbable Destinies: How Predictable Is Evolution? Allen Lane, London. However, experiments in the laboratory or even in the field still do not recapitulate the messy realities of Earth’s history.

  We can deepen our ability: I am reluctant to go as far as suggesting a periodic table of life, a suggestion made in McGhee G. (2011) Convergent Evolution: Limited Forms Most Beautiful. Massachusetts Institute of Technology, Cambridge, MA, because although life forms may be limited, the term periodic table gives the impression that the scope of the evolutionary process has a parity with the simplicity of the atomic structure of elements and a periodicity in structure akin to that of electron stacking. Although I discuss the physical principles at the heart of evolution, I do not claim that the result of the canalization of life by physical principles is a set of life forms as simple as atomic structure. Perhaps a better term would be something like matrix of living forms. Nevertheless, the idea of classifying life systematically in a tabular format broadly similar to the periodic table and according to some agreed-on parameters is an exciting one. Such a classification would be one way to formalize the limits in living form. Similar attempts may be valuable in categorizing niches. See Winemiller KO, Fitzgerald DB, Bower LM, Pianka ER. (2015) Functional traits, convergent evolution, and the periodic tables of niches. Ecology Letters 18, 737–751.

  For instance, the fusiform, sleek body: George McGhee states without ambiguity, “I predict with absolute confidence that if any large, fast-swimming organisms exist in the oceans of Europa—far away in orbit around Jupiter, swimming under the perpetual ice that covers their world—then they will have streamlined, fusiform bodies; that is, they will look very similar to a porpoise, an ichthyosaur, a swordfish, or a shark.” Although large sea creatures in the oceans of Europa are less likely than microbes—if there is any life at all—his point about the physical influence on convergent evolution at the level of the organism and its implications for a notion of universal biology is clear. See McGhee G. (2007) The Geometry of Evolution. Cambridge University Press, Cambridge, 148.

  This understanding might greatly simplify: The observations of convergence at different levels of life’s structural hierarchy also offer hope for simplifying rules of assembly of living things. For example, for a comparison with convergence at the level of whole organisms, see Zakon HH. (2002) Convergent evolution on the molecular level. Brain, Behavior and Evolution 59, 250–261.

  In the finale to his seminal book: Conway-Morris. S. (2004) Life’s Solution: Inevitable Humans in a Lonely Universe. Cambridge University Press, Cambridge.

  Reductionism: I am not a militant reductionist; nor is this book another tired attempt to reduce biology to its simplest physical principles. I echo Mayr’s views that reductionism often destroys information at higher levels of a hierarchy, particularly in complex biological systems, since at higher levels, interactions between components often generate properties not manifest in their separate parts (see, for example, Mayr E. [2004] What Makes Biology Unique? Cambridge University Press, Cambridge, 67). Indeed, the investigation of self-organization and emergent complexity rests on the understanding that behavior at higher levels of biological hierarchy is not merely the sum of behaviors observed at lower hierarchies. As I have illustrated in Chapter 2 and elsewhere in this book, physical principles and equations can be applied to holistic biological entities such as flocks of birds or ant nests. A synthesis of physics and biology need not imply the age-old desire to break down biological phenomena into their tiniest parts, although historically this has often been the case and is often useful to do so.

  INDEX

  A. See adenine

  accoutrements, 98

  Acetobacterium woodii, 151

  Achilles’ heel, of silicon, 190

  acidophiles, 121

  acrylonitrile, 179

  actin (protein), 36–37

  adaptations

  of cell wall, 96

  genetics used to encapsulate, 58

  restrictions to, 10–11

  to salt, 117

  to temperature, 110, 114–115

  adenine (A), 126–128, 132

  adenosine diphosphate (ADP), 149, 160–161, 164

  adenosine triphosphate (ATP), 36, 149–150, 156, 163

  adhesion, equations for ladybug, 40–42

  ADP. See adenosine diphosphate

  aerobic respiration, 101–102, 146–147, 156–160

  aerodynamics, 33, 37, 39, 44, 50, 251

  airfoil, 44, 72, 236

  alien life, 15, 157–158, 214–215, 221, 223, x

  alkali flies (Ephydra hians), 121

  alkaliphiles, 121

  α-helices, 142–143

  ammonia (NH3), 154–155, 172–174, 180, 183

  anammox bacterium, 155

  Antarctica, 65, 119–120

  antibiotics, 98

  ant-like creatures, 38

  ants, 19–20, 23, 233, 249, 257

  evolutionary pressures of, 30–31

  messages between, 26

  nests of, 21–22, 25, 38

  oddities of behavior of, 27–29

  populations of, 22, 24

  self-organizing of, 35

  APM 08279+5255, 181–182

  appall, of creatures, 257

  Arabian Desert, 72

  archaea, 98

  Armstrong, John, 230

  Arrhenius, Svante, 175–176

  Arrhenius equation, 175–176

  arsenobetaine, 210

  Artemia monica (brine shrimp), 121

  Arthropleura (millipede), 53

  Artisan Cheesecakes, Bruntsfield (fictitious shop), 26–27

  astrobiology, 153, 157, 195–196, 226

  astrophysical violence, 1

  Atlas of Our Universe (Gallant), 15

  atomic structure of life, 10, 215

  ATP. See adenosine triphosphate

  Australasia, x

  autopod, 76

  azotosome, 179–180

  B = ρVg (buoyancy term), 74–76, 78–80, 232, 257

  background radiation, 113–114, 176–177, 245

  backyard, 86, 95

  Baja California Sur, 116–117

  Bali, ix–x

  bar-magnets, 7, 168

  barophiles, 123

  Batman Returns (movie), 30

  Benner, Steve, 174–175

  β-sheets, 143

  big bang, 182, 194

  biochemistries, 16, 214

  flexibility in, 135–136

  laws of physics forcing, 100

  metaphor for, 86–87

  new turn in, 209–210

  UV-screening compounds from, 80

  water role in, 180–181

  bioremediation, 155

  bird flocking, 29–33, 38

  birdbrain, 30

&nbs
p; birds, 249, 257

  behavioral patterns of, 31–32

  evolutionary pressures of, 30–31

  heart-rate monitors on, 33

  migration of, 34–37

  reproduction of, 32

  self-organization of, 29, 31, 35

  bloodstream, 169

  boatlike shapes, 191

  borazine, 211

  Boulby mine, 105–109, 116, 118–119

  Boulby Underground Science Facility, 107

  brine shrimp (Artemia monica), 121

  Brock, Thomas, 110

  Broda, Engelbert, 154–155

  Bruntsfield, Edinburgh, 83

  buoyancy term (B = ρVg), 74–76, 78–80, 257

  Burgess Shale, 250–253

  C. See cytosine

  cafés, 145

  caffeate, chemical, 151

  cage-like, molecules as, 85, 87, 192

  Canadian Rocky Mountains, 250

  capillary action, 43

  carbon, 2, 11, 189–194, 197–200

  binding properties of, 213–214

  as element of life, 111, 186, 203, 218, 229

  carbon chemistry, 192–193, 196–205, 214–215, 218, 255

  carbon dioxide gas, 13, 29, 61, 111, 147, 225

  carbonaceous chondrites, 89

  Carboniferous forests, 53

  carbon-water bias, 215

  Carroll, Sean, 72

  Cassini spacecraft, 178

  catch-up game, 178

  C-C bond, 111

  cell theory, 84–85

  cell wall, 96, 98–99

  cells

  chemical reaction rules in, 16

  collecting together of, 102

  compartmentalization of, 90

  development of skin, 78

  Earth covered in, 99

  electrical information transmitted by, 28

  emergence of, 87–88

  entities without, 86

  as fundamental unit of life, 85, 99

  as minuscule, 92–93, 99

  molecule encoding information in, 7

  naming of, 84

  physical principles within, 104

  pigments diffusing through, 36

  predictability in development of, 95

  as preexisting, 85

  shape and rigidity of, 95–96

  temperature influence on atoms in, 109–110

  as veinlike, 103

  water sucked from, 116–117

  See also eukaryotic cells; multicellular aggregates; prokaryotic cells

  cellularity, 86–87, 101, 218

  See also multicellularity

  CH3NO (formamide), 174–175

  chaperonins, 110–111

  Chaunax pictus (pink frogmouth), 77

  chemiosmosis theorem, 150–151, 163–165

  chemolithotrophs, 152

  Chernobyl nuclear reactor, 162

  chitin, 45, 46, 48, 56

  CHNOPS elements, 205, 207–212

  Chroococcidiopsis, 123

  city dwellers, 26

  clap and fling, 45

  Cleveland Potash Limited, 106

  cofactors, in proteins, 212

  comet 67P, 203

  compartmentalization, 85–86, 88, 90, 173, 237–238

  complexity, emergence of, 149, 167, 200, 249, 254

  computer gamers, 30

  contingency, 44, 53, 83, 96–99, 144, 219, 250–257

  convergent evolution, 42, 58, 60–64, 80, 219, 247

  Conway-Morris, Simon, 256

  Cooksonia (earliest land plants), 4

  Copenhagen University, 201

  Copernican revolution, 242

  Cornell University, 179–180

  Crick, Francis, 125–127, 135

  CsB gene, 75

  cyanobacteria, 156

  cytochromes, 153

  cytosine (C), 126–128, 130, 132

  cytoskeleton, 36–37

  Darwin, Charles, 17, 59, 81–82, 90, 231, 242

  Darwinism, 5, 11, 69, 72, 144

  Dawkins, Richard, 66

  Deamer, David, 88–90

  Death Valley, California, 121

  degeneracy, 133

  Deinacrida heteracantha (weta), 52–53

  See also Godzillas

  Deinococcus radiodurans, 123

  dexterous, electrons as, 212

  diffuse interstellar clouds, 168, 178, 196–199, 201

  diffusion, 39, 55, 96

  dilution, 85–86, 88

  dinosaurs, 3, 52–53, 252

  See also sauropsids

  Disney, 30

  divergence, 60, 75

  DNA, 7, 71–72, 127–132

  age before, 70

  damages to, 245

  discovery of, 125–126, 136

  extracting of, 107

  half-life of bonds of, 210

  harboring strains of, 75

  length of, 190

  programming by, 36

  radiation intersection with, 113

  repairing of, 123

  water binding to, 171

  Don Juan Pond, 119–120

  Doppler, Christian, 228

  Doppler effect, 228

  Dracula (movie), 105

  dragonflies, 53

  The Eagle Pub (Cambridge, England), 125

  Earth, 4, 11, 140, 254–255

  biological travelers on, 10

  cells covering, 99

  chemical reactions on, 89–90, 91–92

  commonalities of all life on, 217

  conditions for life production on, 204–205

  crust of, 13

  crystals and salts on, 213

  endosymbiosis on, 102–103

  energy from Sun received by, 146

  environments of, 77–78

  extremes on, 108

  insect life on, 58

  law of gravity as beginning of, 81–82

  as nonexistent, 179

  radiation from within, 113

  simulating of, 203

  Sun circled by, 14

  temperature at center of, 109

  temperature tolerance of, 111–113, 115–116, 121–123

  view of life on, 158

  See also super-Earths

  earthworms, 63–64

  ectotherm, 47

  Ediacara Hills, Southern Australia, 252

  Ediacaran period, 252–253

  Edinburgh, 3–4, 145

  Edinburgh Council, 27

  Egyptian pyramids, 22

  Eidgenössische Technische Hochschule, 130

  electron acceptors, 147–148, 151–155, 229–230

  electron transport chains, 153–154, 156, 158–166, 221

  Enceladus (Saturn moon), 153, 181, 222

  Endless Form Most Beautiful (Carroll), 72

  endosymbiosis, 101–103

  energy, 145, 198

  for brain, 155–156

  chemical change requiring, 246–247

  Earth receiving, from Sun, 146

  equation for producing, 146–147

  of light, equation for, 78–79

  minuscule amount of, 148

  oxygen enabling access to, 160

  potential sources of, 161–165, 180–181

  predictability of best sources of, 230

  Sun production of, 162–163

  systems for gathering, 145–146, 149–150, 155, 220–221, 229–230

  water gathering, 171–172

  See also kinetic energy

  Enterprise, starship, 185

  entropy, 12

  Eötvös Loránd University, 24

  Ephydra hians (alkali flies), 121

  Epulopiscium fishelsoni, 94, 96

  error catastrophe, 220

  Escherichia coli (flagella), 67–68

  eukaryotic cells, 101–102

  Europa (Jupiter moon), 181, 222

  evaporation, rate of, 9

  evo-devo (evolutionary developmental biology), 71–74, 81, 253–254

  evolution, 59–60, 255, ix, x

  as chessboard, 9

&n
bsp; contingency of, 99

  environmental conditions driving, 88

  equations channeling, in life, 58

  as fickle, 108

  forces shaping, 223

  as inevitable, 104

  limb development in, 76

  oceans as analogy for, 8–9

  process of, 5

  radiation excess confronting, 123

  rerun of, 99, 140–141, 233

  selectivity of, 132, 135

  specific routes of, 158

  synthetic biology differing from, 141

  transformation achieved in, 71

  tricks of, 115

  wheel-like contraptions experimented with in, 65–66

  See also convergent evolution

  evolutionary developmental biology (evo-devo), 71–74, 81, 253–254

  exoplanets, 223–233, 237–238

  extinctions, 231

  extremophiles, 107–108

  eyes, of insects, 55

  faunas, 253, ix

  feedback systems, 27–28, 56

  See also negative feedback effect; positive feedback effect

  fermentation, 161

  Fick, Adolf, 51

  Fick’s first law, 52

  filmmakers, 30

  fish, 7, 169, 249

  equation for land transition of, 74–75

  hydrodynamics dictating shape of, 69–70

  oxygen use of, 51

  swimming to walking transition of, 77

  See also surgeonfish

  Fish and Wildlife Service, US, 34–35

  flagella (Escherichia coli), 67–68

  flexibility, 3, 131

  in biochemistries, 135–136

  in development, 73–74

  of elements, 213

  of ladybug wings, 44

  in life, 140

  resilin for, 45

  in tool kit, 139

  walking requiring, 77

  of water, 170

  flight, power of, 3, 236–237

  footholds, legs navigating, 65

  formamide (CH3NO), 174–175

  formose reaction, 201

  4πr2, 93

  Franklin, Rosalind, 125

  Freeland, Stephen, 137–141

  freezing-point-depression constant, 49–51, 113

  freshwater, 167

  friction, 55

  frond-like creatures, 252

  frozen accidents, 126, 129, 135, 140

  Gallant, Roy, 15–16

  gelateria, 200

  genetic code, 12, 244, 250, 254–256

  assembling of, 130

  changes in, 72

  developing of, 90–91, 125–126

  differences produced in, 248

  errors in reading, 133–134

  as expanded, 141

  forms of, 88

  of ladybugs, 56

  modifying, 129

  as not accidental, 136

  predictability and, 136

 

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