a kind of “pabulum”: ibid., 153.
“up to the chemists” to explain: Pollock (1970), 10.
“a bombshell which fell into a fused situation”: Olby (1994), 178.
“had to be practically forced into a taxi”: Pollock (1970), 7.
“There is no consensus of opinion amongst geneticists”: Morgan (1934), 315.
“considered a ‘boring molecule’ or a ‘stupid molecule’ ”: boring: Cobb (2015), 42, 54; stupid: Judson (1979), 59, 63.
“a strange impression” of holy duty seized him: Dubos (1976), 49.
His friends called him “Babe’ ”: ibid., 56.
began to speak of “the transforming principle”: McCarty (1985), 85, 92.
“much more impulsive and impatient”: ibid., 101.
to spray “an invisible aerosol laden with bacteria”: ibid., 104.
no longer “Babe,” far from it, but “the Professor”: Dubos (1976), 4, 62.
“We were not unaware that this idea would be greeted”: McCarty (1985), 143.
“Who could have guessed it?”: Oswald Avery to Roy Avery, May 26, 1943, quoted in Dubos (1976), 218–19.
“This is it, at long last”: McCarty (1985), 171.
“In order that various genes may have the opportunity”: Lederberg and Tatum (1946a), 558.
she detected a system of “sexual compatibility”: Lederberg, Cavalli, and Lederberg (1952), 720; see also “The True History of Fertility Factor F,” Esther M. Zimmer Lederberg Memorial Website,” accessed www.esthermlederberg.com/Clark_MemorialVita/HISTORY52.html, wherein Esther Lederberg asserts her priority of credit.
some sort of “infective hereditary factor”: Lederberg et al. (1952), 729.
alluded likewise to “infective heredity”: Lederberg (1952), 413.
Watanabe called it “an example of ‘infective heredity’ ”: Watanabe (1963), 87.
Its medical significance was “limited to Japan at present”: ibid., 108.
“The discovery of transferable R factors, forty years ago”: Levy (2002), 78–79.
Baker’s team found “intrinsic antimicrobial resistance”: Baker et al. (2014), 1696.
the people of the Solomons were still “an antibiotic virgin population”: Gardner (1969), 774.
a person “from the innermost bush country”: ibid., 775.
“additional VRSA infections are likely to occur”: Miller (2002), 902.
his “great gift” for rubbing people the wrong way: Anthony Tucker, “E.S. Anderson,” Guardian US, last modified March 21, 2006, www.theguardian.com/society/2006/mar/22/health.science.
“is their possible importance in bacterial evolution”: Anderson (1968), 176.
“the temptation is very strong to suggest”: ibid.
“This in turn could favor extremely reticulate modes”: Jones and Sneath (1970), 69.
“It may well be that gene exchange is so frequent”: ibid.
gives the bacterial entity “a huge available gene pool”: Sonea and Panisset (1983), 112.
They called it a “superorganism”: ibid., 8, 85.
Ford Doolittle called it “bold if inchoate”: Doolittle (2004), in Cracraft and Donoghue (2004), 88–89.
“could be evolutionarily significant in promoting trans-kingdom”: Heinemann and Sprague (1989), 205, abstract.
“Can Genes Jump Between Eukaryotic Species?”: Lewin (1982).
an “apparently fanciful and certainly unorthodox” idea: ibid., 42.
“massive” uploads of alien genes: Gladyshev et al. (2008), 1210, 1213.
also found “many hundreds” of foreign genes: Eyres et al. (2015), 1.
“Arguably,” according to one expert, “the spread of Wolbachia represents”: Werren (2005), 299.
“Hundreds of human genes appear likely to have resulted”: Lander et al. (2001), 860.
“the most exciting news” from the Human Genome Project so far: Andersson et al. (2001), 1.
called the Consortium’s claim “at least an overstatement”: Edward R. Winstead, “Researchers Challenge Recent Claim That Humans Acquired 223 Bacterial Genes During Evolution,” Genome News Network, last modified May 21, 2001, www.genomenewsnetwork.org/articles/05_01/Gene_transfer.shtml.
“fresh skirmish in the genome wars”: Nicholas Wade, “Link Between Human Genes and Bacteria Is Hotly Debated by Rival Scientific Camps,” New York Times online, May 18, 2001.
“I was immediately struck by the fact”: quoted in ibid.
PART VI: Topiary
“Dammit, one of these days”: quoted in letter from Hugo Krubsack to Dennis Krubsack, May 13, 1975, cited in “John Krubsack,” Wikipedia, https://en.wikipedia.org/wiki/John_Krubsack.
ignored the crossovers entirely in his “universal phylogenetic tree”: Woese et al. (1990), 4578, fig. 1.
“shattered,” according to one eminent microbiologist: Norman Pace, quoted in Morell (1996), 1043.
“This completes that basic set,” he told Science: ibid.
“you can’t make sense of these phylogenies”: quoted in Pennisi (1998), 2.
“Each gene has its own history”: Robert Feldman, quoted in ibid., 3.
“the last resort of the impoverished imagination”: Doolittle remembers: email to DQ, February 5, 2017.
“Extensive gene transfer,” Brown and Doolittle wrote: Brown et al. (1994), 575.
“The impulse to classify organisms is ancient”: Doolittle (1999), 2124.
He called it the “current consensus” model: ibid., 2125, fig. 2.
“something quite ominous” about these E. coli results: Martin (1999), 101.
He called this one “a reticulated tree”: Doolittle (1999), 2127, fig. 3.
Horizontal gene transfer was “rampant,” he told the readers: Doolittle (2000), 94.
“By swapping genes freely,” he wrote: ibid., 97.
“persuading me of the importance” of HGT: Doolittle (1999), 2128.
They focused on “prokaryote” evolution, using that old word: Gogarten et al. (2002), 2226.
horizontal gene transfer might be the “principal explanatory force”: ibid., 2234.
“too fantastic for present mention in polite biological society”: Wilson (1925), 738–39.
Another . . . discussed the “mosaic” character: Martin (1999), 99.
“quite ominous” to contemplate how HGT must have played out: ibid., 101.
“the tree of 1 percent” of those genomes: Dagan and Martin (2006), 1–2.
what he began calling “the universal phylogenetic tree”: Woese (2000), 8392.
have been called his “millennial series”: Koonin (2014), 197.
“As a cell design becomes more complex and interconnected”: Woese (2002), 8742.
the tree image was “absolutely central” to Darwin’s thinking: Graham Lawton, “Axing Darwin’s Tree,” New Scientist, January 24, 2009.
“There’s a promiscuous exchange of genetic information”: quoted in ibid.
“the uprooting of the tree” as the start of something bigger: ibid.
“What on earth were you thinking”: letter to the editor by Daniel Dennett, Jerry Coyne, Richard Dawkins, and Paul Myers, “Darwin Was Right,” New Scientist, February 18, 2009.
“handing the creationists a golden opportunity”: ibid.
“iconic concept of evolution” that had “fallen on hard times”: Eric Lyons, “Startling Admission: ‘Darwin Was Wrong,’ ” Apologetics Press. www.apologeticspress.org/APContent.aspx?category=23&article=2666.
“turning out to be much more involved”: unsigned editorial in New Scientist, “The Future of Life, but Not as We Know It,” January 24, 2009.
“None of this should give succor to creationists”: ibid.
“the history of life cannot properly be represented”: Doolittle (1999), 2124.
At what point is the “Ship of Theseus”: Doolittle (2004), R176.
It isn’t just an “attractive hypothesis”: Doolittle (2000), 97.
his k
nack with bizarre trees, “I talk to them”: “Axel Erlandson,” Wikipedia, https://en.wikipedia.org/wiki/Axel_Erlandson, quoting from Wilma Erlandson (2001), My Father Talked to Trees, 13.
PART VII: E Pluribus Human
“the ecological community of commensal, symbiotic, and pathogenic”: Lederberg (2001), 2.
“a little white matter, which is as thick”: Leeuwenhoek letter to the Royal Society, September 17, 1683, quoted in “Antony van Leeuwenhoek (1632–1723),” University of California Museum of Paleontology online, www.ucmp.berkeley.edu/history/leeuwenhoek.html.
“Friendship in the kingdom”: the photo appears in Gold (2013), 3206.
“human-associated bacteria”—denizens of the human body: Smillie et al. (2011), 242.
“Taken together, these analyses indicate”: ibid., 242.
“erased the deep ancestral trace” of any uniquely valid: ibid.
called that first ping “the most important email of my life”: Goldenfeld (2014), 248.
“My telephone is 3-9369,” Woese wrote: ibid.
“You may not feel too much at home with biology”: ibid.
“So began a scientific partnership and friendship”: ibid.
The dynamic process involved “non-Darwinian” mechanisms: Vestigian et al. (2006), 10696.
“the coming avalanche of genomic data”: Goldenfeld and Woese (2007), 369.
“Among microbes, HGT is pervasive and powerful”: ibid.
“self-organization” emerging from biological systems: Kauffman (1993), xiii, 22–26.
an “operating system” might have spontaneously taken form: Goldenfeld and Woese (2007), 369.
an “unearthly figure in a full neck brace”: Lewin (2014), 273.
“an unrehearsed statement, a stream of scientific consciousness”: ibid.
Harris Lewin considered himself “an improbable friend”: ibid.
That ended his “isolation” in Morrill: ibid., 275.
“I wanted to do something to honor Carl’s discoveries”: ibid., 276.
“likely to have resulted from horizontal transfer”: Lander et al. (2001), 860.
“an extraordinary trove of information”: ibid.
She called them “controlling elements”: Comfort (2001), 9.
“for her discovery of mobile genetic elements”: ibid., 251, his translation from the Swedish.
“horribly disgusting, to feel numerous creatures”: Keynes, ed. (1988), 315, and n. 1.
“For Carl, winning the Crafoord Prize by himself”: Lewin (2014), 275.
declined to “an engineering discipline”: Woese (2004), 173.
might illuminate “the master plan of the living world”: ibid.
Worse, molecular biology took a “reductionist” perspective: ibid., 174.
“a biology that operates from an engineering perspective”: Woese (2004), 173.
“whose writings I encountered rather late in the game”: Woese (2005), R112.
“jan, you accord darwin so much more substance”: Draft of “Beyond God and Darwin,” in the Woese Archives, University of Illinois, Champaign-Urbana.
“Book 1: Growing Up in Science”: This CVS notebook is in the Woese Archives, University of Illinois, Champaign-Urbana.
“bacteria evolve by leaps and bounds”: Draft of “Beyond God and Darwin,” in the Woese Archives, University of Illinois, Champaign-Urbana.
“The cells that make up our bodies have also not arisen gradually”: ibid.
“Consider too,” Sapp wrote, “that a great percentage of our own DNA”: ibid.
“We made a sort of viral archeology,” Heidmann said: Saib and Benkirane (2009), 4.
genetically modified mice—“knockout” mice: Dupressoir et al. (2005), 730.
clustered regularly interspaced short palindromic repeats: Morange (2015), 221.
These CRISPR-associated genes (cas genes, for short): Jansen et al. (2002), 1565, 1569.
“Modern society knows that it desperately needs”: ibid.
“I rushed to share my out-of-biology experience”: Woese (2007), 4.
“These sequences are sacred scrolls”: Carl Woese to Harry Noller, August 22, 1974; courtesy of Harry Noller.
“obstreperous, petty, and insulting”: Carl Woese to Professor J. Health, May 17, 1988; copy to Harry Noller, which Noller shared with DQ.
“Last night I discovered humor”: Noller (2014), 230.
“Carl was a profoundly creative and fiercely uncompromising scientist”: ibid., 230–31.
“Newly Discovered ‘Missing Link’ Shows”: Rachel Feltman, Washington Post, May 6, 2015.
beware of the “shitkickers” in Section 61: Lewin (2014), 277.
“Sadly, over the next few months”: ibid.
“Species are groups of actually or potentially interbreeding”: Mayr (1942), 120.
often saying “Cut” or “Hold” when he couldn’t summon: These videotapes are available for viewing, with permission, through the Carl R. Woese Institute for Genomic Biology, University of Illinois, Champaign-Urbana.
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