by Siim Land
[407] Drummond MJ, Fry CS, Glynn EL, Dreyer HC, Dhanani S, Timmerman KL, Volpi E, Rasmussen BB. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol. 2009 Apr 1;587(Pt 7):1535-46.
[408] Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H. Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metab. 2011 Feb 2;13(2):170-82.
[409] Muller AF, Janssen JA, Lamberts SW, Bidlingmaier M, Strasburger CJ, Hofland L, van der Lely AJ. Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion. Clin Endocrinol (Oxf). 2001 Oct;55(4):461-7.
[410] Millward, DJ. 'The metabolic basis of amino acid requirements', Accessed 2018: http://archive.unu.edu/unupress/food2/UID07E/UID07E05.HTM
[411] Lemon, PW (2000) 'Beyond the zone: protein needs of active individuals', J Am Coll Nutr, Vol 19(5 Suppl), p 513S-521S.
[412] Anthony TG, McDaniel BJ, Knoll P, Bunpo P, Paul GL, McNurlan MA. J Nutr 2007;137:357-362.
[413] Storr, M et al (2003) 'Endogenous CCK depresses contractile activity within the ascending myenteric reflex pathway of rat ileum', Neuropharmacology, Vol 44(4), p 524-32.
[414] Chandra, R and Liddle RA (2007) 'Cholecystokinin', Curr Opin Endocrinol Diabetes Obes, Vol 14(1), p 63-7.
[415] Garaedts, MC. et al (2011) 'Direct induction of CCK and GLP-1 release from murine endocrine cells by intact dietary proteins', Mol Nutr Food Res, Vol 55(3), p 476-84.
[416] Metcalf AM, et al. (1987) 'Simplified assessment of segmental colonic transit', Gastroenterology, 92:40.
[417] Moore, DR. et al (2009) 'Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men', Am J Clin Nutr, Vol 89(1), p 161-8.
[418] Burd, NA. et al (2011) 'Enhanced Amino Acid Sensitivity of Myofibrillar Protein Synthesis Persists for up to 24 h after Resistance Exercise in Young Men', The Journal of Nutrition, Volume 141, Issue 4, 1 April 2011, Pages 568–573.
[419] Arnal, MA. et al (2000) 'Protein feeding pattern does not affect protein retention in young women', J Nutr, Vol 130(7), p 1700-4.
[420] Soeters, MR et al (2009) 'Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism', Am J Clin Nutr, Vol 90(5), p 1244-51.
[421] Varady, KA. (2011) 'Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss?', Obes Rev, Vol 12(7), e593-601.
[422] Stote KS et al (2007) 'A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults', Am J Clin Nutr, Vol 85(4), p 981-8.
[423] Keogh, JB et al (2014) 'Effects of intermittent compared to continuous energy restriction on short-term weight loss and long-term weight loss maintenance', Clin Obes, Vol 4(3), p 150-6.
[424] Young-Kim et al (2018) 'Update on maximal anabolic response to dietary protein', Clinical Nutrition, Volume 37, Issue 2, April 2018, Pages 411-418.
[425] Umpleby AM and Russell-Jones DL (1996) 'The hormonal control of protein metabolism', Baillieres Clin Endocrinol Metab, Vol 10(4), p 551-70.
[426] Hoffman, JR et al (2010) 'Effect of a proprietary protein supplement on recovery indices following resistance exercise in strength/power athletes', Amino Acids, Vol 38(3), p 771-8.
[427] Schoenfeld BJ, Aragon A. et al (2017) 'Pre- versus post-exercise protein intake has similar effects on muscular adaptations', Peer J, Vol 5, e2825.
[428] Horowitz, JF et al (1997) 'Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise', Am J Physiol, 273(4 Pt 1):E768-75.
[429] Van Proeyen K et al (2010) 'Training in the fasted state improves glucose tolerance during fat-rich diet', J Physiol, Vol 588 (Pt 21), p 4289-302.
[430] Gjedsted J et al (2007) 'Effects of a 3-day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue', Acta Physiol (Oxf), Vol 191(3), p 205-16.
[431] Deldique L et al (2010) 'Increased p70s6k phosphorylation during intake of a protein-carbohydrate drink following resistance exercise in the fasted state', Eur J Appl Physiol, Vol 108(4), p 791-800.
[432] Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988). Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. The Journal of clinical investigation, 81(4), 968-75.
[433] Trabelski, K. et al (2013) 'Effect of fed- versus fasted state resistance training during Ramadan on body composition and selected metabolic parameters in bodybuilders', J Int Soc Sports Nutr. 2013 Apr 25;10(1):23.
[434] Faye J, Fall A, Badji L, Cisse F, Stephan H, Tine P. Effects of Ramadan fast on weight, performance and glycemia during training for resistance]. Dakar Med. 2005;50(3):146-51.
[435] Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem. 2002 Jul 5;277(27):23977-80.
[436] Moscat J, Diaz-Meco MT. Feedback on fat: p62-mTORC1-autophagy connections. Cell. 2011 Nov 11;147(4):724-7. Review.
[437] Yoshizawa F, Kimball SR, Vary TC, Jefferson LS. Effect of dietary protein on translation initiation in rat skeletal muscle and liver. Am J Physiol. 1998 Nov;275(5 Pt 1):E814-20.
[438] Pitkanen HT et al (2003) 'Free amino acid pool and muscle protein balance after resistance exercise,' Med Sci Sports Exerc. 2003 May;35(5):784-92.
[439] Morton RW, Murphy KT, McKellar SR, et al A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults Br J Sports Med 2018;52:376-384.
[440] Marques-Lopes I, Forga L, Martinez JA. Thermogenesis induced by a high-carbohydrate meal in fasted lean and overweight young men: insulin, body fat, and sympathetic nervous system involvement. 2003 Jan;19(1):25-9.
[441] Finn PF, Dice JF. Proteolytic and lipolytic responses to starvation. Nutrition. 2006 Jul-Aug;22(7-8):830-44. Review.
[442] Thompson JR, Wu G. The effect of ketone bodies on nitrogen metabolism in skeletal muscle. Comp Biochem Physiol B. 1991;100: 209–16.
[443] McCarty MF et al (2015) 'Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1', Med Hypotheses. 2015 Nov;85(5):631-9.
[444] Riechman SE (2007) 'Statins and dietary and serum cholesterol are associated with increased lean mass following resistance training', J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1164-71.
[445] https://www.fasebj.org/doi/abs/10.1096/fasebj.25.1_supplement.lb563
[446] Hämäläinen EK, et al (1983) 'Decrease of serum total and free testosterone during a low-fat high-fibre diet', J Steroid Biochem. 1983 Mar;18(3):369-70.
[447] Keys A, et al (1963) 'CORONARY HEART DISEASE AMONG MINNESOTA BUSINESS AND PROFESSIONAL MEN FOLLOWED FIFTEEN YEARS', Circulation 1963 Sep;28:381-95.
[448] Ancel Keys (ed), Seven Countries: A multivariate analysis of death and coronary heart disease, 1980. Cambridge, Mass.: Harvard University Press.
[449] Steinberg D (1989). "The cholesterol controversy is over. Why did it take so long?". Circulation. 80(4): 1070–1078.
[450] Katz LN, Keys A, Gofman JW (1952). "Atherosclerosis. A Symposium: Introduction"(PDF). Circulation. 5: 98–100.
[451] Reiser Raymond (1973). "Saturated fat in the diet and serum cholesterol concentration: a critical examination of the literature" (PDF). Am J Clin Nutr. 26: 524–555.
[452] Pett, Kahn, Willett, Katz (2017). "Ancel Keys and the Seven Countries Study: An Evidence-based Response to Revisionist Histories" (PDF). True Health Initiative.
[453] Nago N et al (2011) 'Low cholesterol is associated with mortality from stroke, heart disease, and cancer: the Jichi Medical School C
ohort Study', J Epidemiol. 2011;21(1):67-74.
[454] Bae JM et al (2012) 'Low Cholesterol is Associated with Mortality from Cardiovascular Diseases: A Dynamic Cohort Study in Korean Adults', J Korean Med Sci. 2012 Jan; 27(1): 58–63.
[455] Parthasarathy S et al (2012) 'Oxidized Low-Density Lipoprotein', Methods Mol Biol. 2010; 610: 403–417.
[456] Vanderlaan PA et al (2009) 'VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice', J Lipid Res. 2009 Mar; 50(3): 376–385.
[457] National Health and Nutrition Examination Study, 'Intake of Calories and Selected Nutrients for the United States Population 1999-2000', Accessed: https://www.cdc.gov/nchs/data/nhanes/databriefs/calories.pdf
[458] Johnson, TD (2010) 'Mind your cholesterol for a healthy heart', The Nation's Health April 2010, 40 (3) 24.
[459] Dubois C et al (1994) 'Effects of increasing amounts of dietary cholesterol on postprandial lipemia and lipoproteins in human subjects', J Lipid Res. 1994 Nov;35(11):1993-2007.
[460] Lecerf, J., & De Lorgeril, M. (2011). Dietary cholesterol: From physiology to cardiovascular risk. British Journal of Nutrition, 106(1), 6-14.
[461] Westman EC et al (2006) 'Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses', Int J Cardiol. 2006 Jun 16;110(2):212-6.
[462] Cordain L et al (2004) 'Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal', J Am Coll Cardiol. 2004 Jun 2;43(11):2142-6.
[463] Djousse, L. and Gaziano JM (2009) 'Dietary cholesterol and coronary artery disease: a systematic review', Curr Atheroscler Rep. 2009 Nov;11(6):418-22.
[464] Griffin, JD and Lichenstein, AH (2013) 'Dietary Cholesterol and Plasma Lipoprotein Profiles: Randomized-Controlled Trials', Curr Nutr Rep. 2013 Dec; 2(4): 274–282.
[465]Lecerf, JM and de Lorgeril, M (2011) 'Dietary cholesterol: from physiology to cardiovascular risk', British Journal of Nutrition (2011), 106, 6–14.
[466] Caroll MD et al (2012) 'Total and high-density lipoprotein cholesterol in adults: National Health and Nutrition Examination Survey, 2009-2010'. NCHS Data Brief. 2012 Apr;(92):1-8.
[467] Nago N et al (2011) 'Low cholesterol is associated with mortality from stroke, heart disease, and cancer: the Jichi Medical School Cohort Study', J Epidemiol. 2011;21(1):67-74.
[468]Bueno, NB et al (2013) 'Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials', British Journal of Nutrition, Volume 110, Issue 7 14 October 2013 , pp. 1178-1187.
[469] Brinkworth GD et al (2009) 'Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo', Am J Clin Nutr. 2009 Jul;90(1):23-32.
[470] Dashti HM et al (2004) 'Long-term effects of a ketogenic diet in obese patients', Exp Clin Cardiol. 2004 Fall;9(3):200-5.
[471] Nutrition Week Mar 22, 1991 21:12:2-3
[472] Barnard N et al (2014) 'Saturated and trans fats and dementia: a systematic review', Neurobiology of Aging, Volume 35, Supplement 2, September 2014, Pages S65-S73.
[473] Pase CS et al (2013) 'Influence of perinatal trans fat on behavioral responses and brain oxidative status of adolescent rats acutely exposed to stress', Neuroscience. 2013 Sep 5;247:242-52.
[474] Harvard T.H. Chan, The Nutrition Source, 'Omega-3 Fatty Acids: An Essential Contribution', Accessed: https://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/fats-and-cholesterol/types-of-fat/omega-3-fats/
[475]The Source for Objective Science-based DHA/EPA Omega-3 Information, DIFFERENTIATION OF ALA (PLANT SOURCES) FROM DHA + EPA (MARINE SOURCES) AS DIETARY OMEGA-3 FATTY ACIDS FOR HUMAN HEALTH, Accessed: http://www.dhaomega3.org/Overview/Differentiation-of-ALA-plant-sources-from-DHA-+-EPA-marine-sources-as-Dietary-Omega-3-Fatty-Acids-for-Human-Health
[476] Garg, A (1998) 'High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis', Am J Clin Nutr. 1998 Mar;67(3 Suppl):577S-582S.
[477] Finucane, OM et al (2015) 'Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity', Diabetes. 2015 Jun;64(6):2116-28.
[478]PM Kris-Etherton, Denise Shaffer Taylor, Shaomei Yu-Poth, Peter Huth, Kristin Moriarty, Valerie Fishell, Rebecca L Hargrove, Guixiang Zhao, Terry D Etherton; Polyunsaturated fatty acids in the food chain in the United States, The American Journal of Clinical Nutrition, Volume 71, Issue 1, 1 January 2000, Pages 179S–188S.
[479] Leaf A and Weber PC (1988) 'Cardiovascular effects of n-3 fatty acids', AGRIS, Accessed: http://agris.fao.org/agris-search/search.do?recordID=US8845581.
[480] Russo GL (2009) 'Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention', Biochem Pharmacol. 2009 Mar 15;77(6):937-46.
[481]Hiza, HAB and Bente L (2007) 'Nutrient Content of the U.S. Food Supply, 1909-2004, A Summary Report', Center for Nutrition Policy and Promotion, Home Economics Research Report No. 57.
[482] Nair U et al (2007) 'Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans', Free Radic Biol Med. 2007 Oct 15;43(8):1109-20.
[483] Ghosh S et al (2007) 'Cardiac proinflammatory pathways are altered with different dietary n-6 linoleic to n-3 α-linolenic acid ratios in normal, fat-fed pigs', American Journal of Physiology-Heart and Circulatory Physiology 2007 293:5, H2919-H2927.
[484] US FDA, Trans Fat, Accessed 2018: https://www.fda.gov/food/ucm292278.htm
[485] Menendez JA et al (2005) 'Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification', Ann Oncol. 2005 Mar;16(3):359-71.
[486] Siri-Tarino PW et al (2010) 'Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease', Am J Clin Nutr. 2010 Mar;91(3):535-46.
[487] Wakai, K. et al 'Dietary intakes of fat and total mortality among Japanese populations with a low fat intake: the Japan Collaborative Cohort (JACC) Study', Nutr Metab (Lond). 2014; 11: 12.
[488] Price, Weston, DDS Nutrition and Physical Degeneration, 1945, Price Pottenger Nutrition Foundation, Inc., La Mesa, California
[489] Cohen, L A et al, J Natl Cancer Inst 1986 77:43.
[490] World Health Organization (2015) 'Q&A on the carcinogenicity of the consumption of red meat and processed meat', Accessed: http://www.who.int/features/qa/cancer-red-meat/en/
[491] Armstrong B and Doll R (1975) 'Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices', Int J Cancer. 1975 Apr 15;15(4):617-31.
[492] Koeth RA et al (2013) 'Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis', Nat Med. 2013 May;19(5):576-85.
[493] Alexander DD et al (2011) 'Meta-analysis of prospective studies of red meat consumption and colorectal cancer', Eur J Cancer Prev. 2011 Jul;20(4):293-307.
[494] Micha R et al (2010) 'Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus A Systematic Review and Meta-Analysis', Circulation. 2010;121:2271–2283.
[495] Micha, R., Wallace, S. K., & Mozaffarian, D. (2010). Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis. Circulation, 121(21), 2271-83.
[496] Davey GK et al (2003) 'EPIC-Oxford: lifestyle characteristics and nutrient intakes in a cohort of 33 883 meat-eaters and 31 546 non meat-eaters in the UK', Public Health Nutr. 2003 May;6(3):259-69.
[497] LaFleur J, Nelson RE, Sauer BC, et al Overestimation of the effects of adherence on outcomes: a case study in healthy user bias and hypertension Heart 2011;97:1862-1869.
[498] Shrank,
W.H., Patrick, A.R. & Alan Brookhart, M. J GEN INTERN MED (2011) 26: 546.
[499] Key TJ et al (1996) Dietary habits and mortality in 11,000 vegetarians and health conscious people: results of a 17 year follow up', BMJ. 1996 Sep 28;313(7060):775-9.
[500] Jonathan M. Hodgson, Natalie C. Ward, Valerie Burke, Lawrence J. Beilin, Ian B. Puddey; Increased Lean Red Meat Intake Does Not Elevate Markers of Oxidative Stress and Inflammation in Humans, The Journal of Nutrition, Volume 137, Issue 2, 1 February 2007, Pages 363–367.
[501] Wang Z et al (2011) 'Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease', Nature. 2011 Apr 7;472(7341):57-63.
[502] Zhang AQ et al (1999) 'Dietary precursors of trimethylamine in man: a pilot study', Food Chem Toxicol. 1999 May;37(5):515-20.