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To Ruta, Sofia, and Naomi, for putting up with me.
UNITED NATIONS OUTPOST
Highly Confidential Memo 25 January 2013
The enclosed documents are highly classified. They are exact replicas of the recently recovered handwritten notes of Dr. Stanley Blum, the last scientist sent to the United Nations Sanctuary for the study of ANSD and “zombie” biology. After careful examination, World Health Organization and United Nations officials have reason to believe that these writings may contain groundbreaking data regarding the nature of the ANSD pathogen. Furthermore, it is possible that this information represents both a key to a viable cure, as well as the most definitive evidence to date that the ANSD virus was artificially manufactured—human made—and therefore did not occur naturally. The importance of these potential conclusions cannot be overstated.
One-third of humanity has perished from the plague. Two point three billion people have died, and countless more are quickly moving toward the final stages of disease. There is reason to believe that in a short time nearly everyone on Earth will be infected. The virus continues to spread exponentially, and all attempts at a vaccine or a cure have failed. Scientific and industrial infrastructure is rapidly faltering. Early attempts at controlling the spread of disease via nuclear and non-nuclear incineration have left the planet in an ecologically fragile state. Current computer models suggest that civilization can only survive for approximately another decade before we face total destruction. These are indeed dire times. The information in this journal may very well represent our last hope.1
BACKGROUND
Less than three years ago, the idea that a “zombie plague” would threaten all of humanity was preposterous. Indeed, the very nature of this claim prevented swift and decisive action from the world community. Nevertheless, “zombie” is arguably the most recognizable term for those who have been infected with ANSD and have reached the fourth stage of the disease.
Ataxic Neurodegenerative Satiety Deficiency Syndrome (ANSD), the internationally accepted diagnostic term for what is more commonly referred to as zombiism, continues to spread unabated. While some islands remain disease free, ANSD is otherwise present on every major landmass. Most of the governed world is under martial law. The signs and symptoms of the disease are universally known, but the disease itself appears both indestructible and untreatable.
In July 2012, the United Nations established a study site on the island of Bassas da India in the Indian Ocean. The official charter for this site called for a laboratory setting where the world community could focus its efforts on the scientific study of ANSD, including anatomic explorations of zombies themselves, as well as molecular investigations of the presumed contagion. This site is formally known as the United Nations Sanctuary and Study Site (UNSaSS) but is more commonly referred to at the UN bunkers as the Crypt. Those who volunteer to participate in the work on the island understand that a return to the bunkers is not permitted and scientists started referring to the site as the Crypt in an effort to acknowledge the blunt reality of their important and difficult tasks.
On 11 November 2012, the UN received its last message from the Crypt. The message was a radio transmission, and, as with most digital communications, the content was badly garbled due to nuclear interference. It is important to note that we had not received any e-mail contact from the island for some time, and the voice message was received over a little-used commercial satellite frequency. Voice analysis has suggested with reasonable certainty that the communication was from Dr. Blanca Gutierrez, who was at that time the resident microbiologist on the island. After significant digital analysis, the message reads as follows:
Status… gent. Hype.... ....new. Diff… virus. Vaccine… ble
An international group of scientists, policy makers, epidemiologists, and ethicists has theorized that Gutierrez had new information regarding a viable vaccine. It is unclear whether “hype” refers to “hyper” (a possible acceleration of disease progression) or, more likely, to the hypothalamus, a region of the brain oddly not affected by ANSD infection. The “-ble” suffix at the end is consistent with words such as “possible,” “viable,” or, conversely, “impossible.” We are fairly certain that “gent” is most consistent with the word “urgent.”
No further communications were received, and attempts to communicate with the island were unsuccessful. At that time, UN records show that Gutierrez’s team included Dr. James Pittman, a Canadian anatomist and medical illustrator; Dr. Anita Gupta, a leading virologist from Delhi; as well as three military attachés. There were also an unspecified number of infected humanoids in the holding facility.
On 14 November 2012, a team of three individuals was sent to investigate the Crypt in an attempt to regain contact with Gutierrez and her colleagues. Dr. Sarah Johnson, a Scottish neurobiologist and expert in viral brain infections; Dr. Jose Martinez, the chief forensic pathologist for the former New York City; and Dr. Stanley Blum,2 a neurodevelopmental biologist with the United States Centers for Disease Control (CDC), were selected for the mission. While Drs. Martinez and Johnson were chosen for their scientific expertise, Blum’s orders were to record the findings of the team and to ensure that these findings were reviewed by scientists in the international ANSD research community.
All three set out in separate automated transport planes programmed to bypass the security apparatus at the UNSaSS. Unfortunately, only Dr. Blum arrived safely on the island. After an automated transmission from Dr. Blum signaling his arrival, communication with the island was lost altogether.
At that time, ANSD experts felt the risk of further exploration of the Crypt was too great. Researchers on the island were genetically manipulating the virus, and ANSD experts were consequently reluctant to potentially release an even more dangerous form of the contagion from the sterile confines of the study site. However, as already noted, world conditions continued to rapidly deteriorate. The decision was therefore made to pursue excavations of the Crypt with the primary goal of understanding the final transmission from Gutierrez.
After extensive precautions, the study site was thoroughly investigated for seven days, 8–15 January 2013. Three of the seven surveyors have since died from ANSD, and the remaining four have all shown signs of progressive infection. We are grateful for the courage and sacrifice made by those who conducted the surveillance.
Surveyor 3, Captain Amy McBride of the elite British Special Boat Service, was among the first to succumb to Stage IV disease while on the island. As protocol dictated, she was fatally shot by members of the surveillance team. Although she had collected only limited data onto her hard drive, the team failed to search her personal belongings, presumably in their efforts to quickly sterilize the body for transportation back to the UN base. She was frozen in liquid nitrogen and sealed in an automated marine transport unit. Navigational malfunctions prevented the remains of Captain McBride from arriving at the docking station until last week. Upon arrival, the handwritten laboratory notes of Dr. Stanley Blum were discovered in her backpack.
Dr. Blum’s writings are presented here in preparation for tomorrow’s meeting. His journal, as noted, is handwritten, and he and Dr. Pittman made extensive sketches and diagrams to document their work. The final pages of his notebook are frustratingly unclear, and physicians here speculate that he was traumatized as well as suffering from the cognitive effects of the treatments used to slow progression of ANSD toward zombiism.
The standard of care for treatment of ANSD infection rema
ins an artificially induced increase in human pH. This technique was first described by Blanca Gutierrez and has been referred to as the Gutierrez protocol. Unfortunately, the effects of these measures create a number of significant neurological side effects that ironically mimic the cognitive decline consistent with full zombie status. Thus, it is unclear why Blum’s cognitive state appears to decline throughout his notebook. He was either suffering from the effects of the Gutierrez protocol or was in fact slowly moving toward zombie status.
Nevertheless, it is possible that careful examination of this material will yield crucial answers. Most important, when Gutierrez left for the Crypt, she was already pursuing a theory that ANSD spread when it combined with still-unidentified additional infectious agents. If those agents could be detected, then there was a much greater likelihood of creating a viable cure. She therefore intended to pursue her theory by examination of infected humanoids while looking for additional pathogens.
These investigations had not yet been pursued by scientists at the Crypt or anywhere else, and Gutierrez insisted that she go herself. She felt strongly that investigations would have to be thorough and that findings from previous autopsies would need to be selectively discarded. Her expertise in molecular biology, microbiology, and vaccine development made her especially well suited for the position, though her commitment also meant that she would expire on the island. Thus, her efforts were both heroic and potentially scientifically groundbreaking. She asked that Dr. Anita Gupta join her as a co-investigator in this project, given Gupta’s expertise in viral infections of the brain.
While Blum’s journal documents Gutierrez’s fate, we remain somewhat unsure how Blum himself expired. We are relatively confident that the decomposed body in the infirmary described by the surveyors was Blum’s. Unfortunately, digital images of the site obtained by the surveyors are badly distorted by electromagnetic interference. Computer reconstruction teams are working to create interpretable images, but at the current time we have only the debriefings from the remaining surveyors, and none has the cognitive capacity to offer reasonable explanations.
The ANSD Working Group has elected to prepare this written briefing in order to maximize the work at tomorrow’s meeting. Many of their annotations in the following notebooks will be rudimentary for the scientists on the panel, but it is important that all who see this material be able to participate as effectively as possible in the discussion.
We must not lose hope. One-third of humanity remains. It is fair to note that tomorrow’s meeting is among the most important gatherings in human history. If there are questions, do not hesitate to contact your facilitator. Good luck.
BLUM’S HANDWRITTEN NOTEBOOK AND THE ANNOTATED COMMENTS FOLLOW
NOVEMBER 16, 2012
6:15 AM—ON BOARD THE AUTOMATED TRANSPORT
I’m writing this because I need to believe that there is hope.
What would be the point, otherwise? Why would I go?
I am Dr. Stanley Blum, an administrator at what’s left of the Centers for Disease Control. I have a medical degree and a PhD in neuroscience, but I haven’t held a test tube in over twenty years. Before the plague, I was pushing paper around my desk in Atlanta. I haven’t treated a patient since medical school. I didn’t do a residency. I mostly tried to stay out of the way and enjoy my family.
That was all before. If I lean over right now, I can see through the scratched window of the transport plane. The world is barren, hazy, apocalyptic. Only a fool would have hope.
But Gutierrez is the smartest person I’ve ever met. If we’re right, if she is on to something, then there is hope. And someone has to write about it. I’ve seen enough computer malfunctions over the last year to know better than to type this on my laptop. I will write everything down. I don’t plan to survive this trip, but this notebook just might.
And we just might find something new, something we can use, something we didn’t understand or didn’t even know before… Something that can cure us.
Something that can save us.
In other words, we need to start over.
Gutierrez’s plan was to dissect each humanoid as if it were the first autopsy ever done by anyone. She was going to act as if we’d never seen them before. This was the only way, the only real hope that we would find anything useful, something we didn’t already know, something we hadn’t already tried.
And it all has to be written down.
I will record everything. Everything I see, every theory we consider, every success, every failure. There might not be any scientists left when—or if—anyone ever reads this. This might be all anyone will have to make sense of this mess. So it has to make sense to everyone. Because everyone could be anyone.
8:00 AM
STILL ON BOARD THE TRANSPORT PLANE.
Trying to organize my thoughts. Can’t look at the textbooks and manuscripts anymore—my eyes hurt and I’m tired. Here’s what we know so far:
The natural history of the infection varies greatly, with time from contact to symptoms anywhere from two or three minutes to up to seven days. Classifiers at the WHO have cataloged the natural progression of disease as follows:
Stage I—Onset of extreme hunger with coexisting fever and upper respiratory symptoms. Cognitive lucidity is maintained. Stage I lasts from two minutes to three days.
Stage II—Worsening fever with measured temperatures up to 105°F. Cough worsens and cognitive decline begins with confusion and delirium. Hunger intensifies, with a preference for large, living organisms. Balance begins to suffer, with a wide, staggered gait. Arms are often held in front to maintain posture. Names and people are usually still recognized but with significant confusion. Stage II lasts from one to twenty-four hours.
Stage III—Ongoing fever, worsening delirium, and significant cognitive decline. Neurological effects are profound, with frequent falls and increased aggressive behavior. From observation, hunger appears to increase, though subjects are no longer able to speak coherently and cannot accurately convey their feelings. Previous autopsies have demonstrated significant abnormalities in the gastrointestinal organs. Malabsorption and inability to process food predominate. Stage III lasts no more than four hours.
Stage IV—Complete loss of human characteristics. Officially categorized as “No Longer Human”—“NLH”—by the UN and the WHO. These are the true zombies. That’s what we called them when we first tried to describe their behavior, and the term, though crass, works. That’s what they are… They have no capacity to recognize others as anything other than prey. They demonstrate profoundly hyperaggressive behavior. Everything that’s human is gone.
The zombie bug is a virus, related to seasonal flu, a strain of influenza. It is spherical and not segmental. This means that electron micrographs show that the virus is round, not rectangular. Spherical influenza viruses—the ones that are round in shape—are substantially more consistent with manufactured laboratory strains and seen much less commonly in nature. This is probably why Blanca thinks this bug might not be an accident. Someone may have made this thing. A bug this virulent, this tough, this scary: It wouldn’t happen by accident.
Unlike seasonal flu, this bug is unusually capable of flourishing outside the lungs. And just like the common cold, it is largely transmitted via respiratory droplets. We didn’t know this for sure a year ago, but we suspected as much. Now we know. Every cough, every sneeze, every wheeze spews millions of virions. And each virion is a single, infective virus, a zombie waiting to happen.
There are prions in the body of the virus. The word is actually a combination of two words: “protein” and “infection.” They’re called prions because no one quite understands what they are other than infective proteins.
ANSD virus
But things that infect are alive, and proteins are not living organisms. This is one of the oldest mysteries of modern medicine. How can something that isn’t alive infect and reproduce?
Prions can cause spongiform changes to mammalian brains
, and they’re usually contracted by humans through direct oral ingestion. The changes are called spongiform because transformed brain tissue literally looks like a sponge, like mush.
The prions in ANSD do not affect all brain regions equally—also unusual in prion behavior. For unclear reasons, the amygdala, and especially the hypothalamus, are preserved.
We do not have a good understanding of how the prions make their way to the central nervous system. How do they get from the lungs to the brain?
Vaccine trials have involved both attenuated (or harmless) live viruses as well as nonliving antigen-based compounds, which are components of the virus itself. With the live virus, we kept altering it, changing its molecular structure in ways that ought to have made it only mildly pathogenic but still infective enough to generate antibodies. This is routine for vaccine development. Both methods theoretically develop immunity in the host. Our trials failed, though. In fact, what we saw with the altered live virus was terrifying. The bug always reverted, always “knew” how to fix itself. It was as if it was expecting us to change it and was already programmed to change itself back. So in most cases, there was temporary success, and in all cases eventual failure. To date, no cure or vaccine exists.
The Zombie Autopsies: Secret Notebooks from the Apocalypse Page 1