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Connectome

Page 40

by Sebastian Seung


  Index

  Page numbers in italics refer to illustrations.

  Abstract ideas, [>]

  Action potentials (“spikes”), [>]–[>]. See also Spikes and spiking

  Adaptation of cortical areas. See Remapping of cortex

  Aging, efforts to suspend, [>]. See also Cryonics; Plastination; “Uploading”

  AIDS, [>]–[>]

  Alcoholics Anonymous, Serenity Prayer of, [>], [>]

  Alcor Life Extension Foundation, [>]–[>], [>], [>], [>]

  promises of, [>]

  and transhumanism, [>]

  uncertainties over, [>], [>], [>], [>], [>]

  Ali, Muhammad, [>]

  Allen, Woody, on immortality, [>]

  Allocortex, [>]

  Alzheimer’s disease (AD), [>], [>], [>], [>]

  mouse models of, [>]

  Amblyopia, [>]–[>], [>]

  Amino acids, [>]

  Amnesiacs, denial by, [>]

  Amputation, and phantom limbs, [>], [>]–[>], [>]

  Aniston, Jennifer, as perception example, [>], [>]–[>], [>], [>], [>], [>], [>], [>], [>], [>]

  Antibiotics, [>], [>]

  Antidepressants, [>], [>]–[>], [>]–[>]

  Antipsychotics, [>], [>]–[>], [>], [>]

  Antonini, Antonella, [>]–[>], [>]

  Aphasia, [>]

  Broca’s, [>], [>]

  conduction, [>], [>]

  Wernicke’s, [>], [>]

  Aplysia californica, [>]–[>]

  Apple Incorporated, modern miracles from, [>]

  Archaeological metaphor for neuroanatomy, [>]–[>]

  Arcuate fasciculus, [>], [>], [>], [>]

  Ariadne, [>], [>]

  Aristotle, on memory, [>]–[>]

  and associationism, [>]

  Artificial intelligence, [>]–[>]

  evaluation of, [>]–[>]

  limitation of, [>], [>]

  Ascaris lumbricoides, [>]

  Asperger’s syndrome, [>]

  ASPM, [>]

  Association(s), [>], [>]

  learning of, [>]–[>]

  sequential rule of, [>], [>]

  simultaneous rule of, [>]

  and sparse connectivity, [>]–[>]

  Associationism, [>], [>]

  ATUM (automated tape-collecting ultramicrotome), [>]–[>], [>], [>]

  “Augmenting Human Intellect” (Engelbart), [>]

  Autism, [>], [>], [>]–[>], [>], [>], [>]–[>]

  attempt to study in animals, [>]

  cause of (genetic vs. environmental), [>]–[>], [>]

  as connectopathy, [>], [>]

  drugs for (and miswiring in animal models), [>]

  genetics of, [>]

  genetic tests for, [>]

  and genomics, [>], [>]–[>]

  and ion channels, [>]

  lack of neuropathology in, [>], [>], [>]

  multiple forms of, [>]

  Autism spectrum disorders, [>]

  Axons, [>]–[>], [>]–[>]

  cross-sections of, [>]

  in dead brains, [>]

  as divergent, [>]

  growth of after birth, [>]

  myelinated, [>]

  and spiking, [>] (see also Spikes and spiking)

  white matter as, [>]–[>]

  mapping of, [>], [>]–[>]

  and wiring of brain, [>]

  Bacon, Francis, [>]

  Bailey, Percival, [>]

  Balanced population, [>]

  “Ball and stick” models, [>], [>]

  Barry, Susan, [>]

  Basal ganglia, [>]

  Baudelaire, Charles, [>]

  Behavior Genetics, Laws of, [>], [>]

  Bernal, J. D., [>]–[>]

  Bicêtre hospital, [>]–[>]

  Binding site, [>]

  “Biologics,” [>]

  Biomolecules, and drug therapy, [>]

  Bipolar disorder, [>]

  Birds, [>]

  similarities of to humans, [>]

  songs of, [>]–[>]

  examination of to find synaptic chains, [>]–[>], [>]

  “Blank slate” view of mind, [>]

  Blue Brain (computer simulation), [>]–[>], [>]–[>], [>]

  Blue Gene/L (computer), [>]

  Blum, Joseph, [>]

  Bock, Davi, [>]

  BOLD (blood oxygen level dependent) signal, [>]

  Bonin, Gerhardt von, [>]

  Boundary detection, [>]–[>], [>]

  Bragg, Lawrence, [>]

  Braille readers, [>]

  Brain(s)

  abnormalities in

  lissencephaly, [>]–[>], [>]

  microcephaly, [>], [>]

  adult plasticity of, [>]

  “areas” and “regions’ of, [>]

  change in (and learning new behavior), [>]–[>]

  complexity of, [>], [>]

  death of, [>]–[>]

  as connectome destruction, [>]–[>]

  development of, [>]

  and abnormalities, [>], [>], [>]

  change easiest in early stages of, [>]

  and gene therapy, [>]–[>]

  and organizational patterns, [>]–[>]

  synapse creation and destruction, [>]–[>], [>]

  enhancing normal function of, [>]

  fMRI in mapping of, [>]–[>]

  forest metaphor for, [>], [>]

  complexity of, [>]

  hierarchical perceptron model for, [>]

  individual differences in functioning of, [>], [>], [>], [>]

  as irreplaceable, [>]–[>]

  Labyrinth metaphor for, [>]–[>]

  left vs. right, [>]

  and hemispherectomy in children, [>]

  and sides of body, [>]

  MRI cross-section of, [>]

  muscles compared with, [>]–[>]

  as mysterious, [>]

  and neuroanatomy, [>]–[>]

  and neurons (see also Neurons)

  and connections between, [>]

  number of, [>]

  organization of, [>], [>]

  plastination of, [>]–[>]

  in recovery from stroke, [>]–[>]

  regions of studied, [>]

  rewiring of, [>], [>]–[>], [>], [>] (see also Rewiring of brain)

  size of

  and autism, [>]–[>]

  and intelligence, [>]–[>]

  measurement of, [>]–[>]

  and mental differences, [>], [>]

  and schizophrenia, [>]–[>]

  structure of, [>]–[>], [>], [>]

  and connectionism, [>]–[>]

  and different levels of activation, [>]–[>]

  vs. function as criterion for division, [>]

  and genius, [>]–[>]

  and individual differences, [>], [>], [>]

  and localizationism, [>]–[>] (see also Localizationism)

  measurement in study of, [>]

  and neuron types, [>], [>]–[>], [>]

  proper division of, [>]–[>], [>]–[>]

  similar functions within region of, [>]

  and specific abilities, [>]

  study of

  as available approach to understanding, [>]

  and regions, [>]

  of Tan, [>]

  and technologies, [>] (see also Technological innovation)

  and thinking, [>] (see also Thought)

  transfer of functions between parts of, [>]–[>], [>]–[>], [>]

  and equipotentiality, [>]–[>]

  “wiring” of, [>]–[>] (see also Connectome)

  in childhood vs. adulthood, [>]–[>]

  and connections between regions, [>]–[>]

  and dead brains, [>]–[>]

  wires across boundaries, [>]

  See also Cortex; other brain parts

  Brain archaeology, neuroanatomy as, [>]

  Brain disorders

  epilepsy, [>], [>] (see also Epilepsy)

  infectious, [>]–[>]

  treatment of, [>]

  development of drugs for,
[>]–[>]

  primitive methods of, [>]

  through regeneration, [>]–[>]

  and research on areas, [>]–[>]

  through rewiring, [>]–[>]

  for stroke, [>], [>], [>]–[>]

  See also Mental disorders and disabilities; Neurodegenerative disorders

  Brain injury

  and cortical area acquiring new function, [>]

  denial of by victim, [>]

  in identifying cortical areas, [>]–[>]

  from oxygen deprivation, [>]

  recovery from quicker in earlier time of life, [>]

  regeneration as treatment for, [>]–[>]

  and regional connections, [>]–[>]

  and regions affected, [>]

  rewiring facilitated by, [>], [>]

  in stroke, [>]–[>]

  symptoms of, [>]

  Brain of monkey, map of, [>], [>]

  Brain Preservation Prize, [>]

  Brain simulation, [>]–[>]

  atom-by-atom, [>]

  and change, [>]

  connectome as basis for, [>]–[>]

  and controversy over cat brain, [>]–[>]

  and extrasynaptic interactions of neurons, [>]–[>]

  and neuron-variety problem, [>]–[>]

  success criterion for, [>]–[>]

  See also Computer simulation; “Uploading”

  Brainstem, [>], [>], [>]

  “Brainstem death,” [>]–[>]

  Brain That Changes Itself, The: Stories of Personal Triumph from the Frontiers of Brain Science (Doidge), [>]

  Brain tissue, in ultramicrotome, [>]

  “Brain in a vat” scenario, [>]

  Brave New World (Huxley), [>]

  Brenner, Sydney, [>]–[>]

  Brief History of Time, A (Hawking), [>]–[>]

  Briggman, Kevin, [>]

  Broadcasting, [>]

  Broca, Paul, [>]–[>], [>]–[>], [>]

  Broca’s aphasia, [>], [>]

  Broca’s region, [>], [>], [>], [>]

  connected to Wernicke’s region, [>]–[>]

  and stroke damage, [>]

  Broca-Wernicke model of language, [>], [>], [>]

  replacement for, [>]

  Brodmann, Korbinian, [>], [>], [>], [>]

  Brodmann’s map, [>], [>], [>], [>], [>]–[>], [>]

  and brain damage, [>]

  Lashley on, [>]

  and synapse creation, [>]

  Brooks’ Law, [>]

  Byron, Lord, [>]

  Caffeine, and brain function, [>]

  Cajal, Santiago Ramón y

  and neuron classification, [>], [>], [>], [>], [>], [>], [>], [>]

  and neuron contact, [>], [>], [>], [>], [>]

  neurons drawn by, [>], [>]

  Nobel Prize to, [>]

  Calculus, simultaneous discovery of, [>]

  Campbell, Alfred, [>]

  Camus, Albert, [>]–[>]

  Candide (Voltaire), [>]

  Cat brain simulation, controversy over, [>]–[>]

  CA3 region of hippocampus, [>], [>], [>], [>]

  C. elegans worm(s), [>]–[>], [>]–[>], [>], [>]

  connectome of mapped, [>]–[>], [>], [>]

  as connectome twins, [>]–[>]

  map of nervous system (connectome) of, [>], [>], [>]

  neuron types in, [>]–[>]

  “reduced” connectome of, [>]

  simulation of (and neuron models), [>]–[>]

  slice of, [>]

  types of neurons in, [>]

  Cell(s), [>]

  Bernal on future manipulation of, [>]

  ice inside as fatal, [>]

  “programmed” death of, [>]

  Cell assembly(ies), [>], [>]–[>], [>], [>], [>], [>], [>], [>]

  creation of, [>]–[>], [>], [>], [>]

  overlapping, [>]

  spiking of, [>]

  Cell body, of neuron, [>]

  Cell theory

  acceptance of, [>]

  as cornerstone of biology, [>]

  Central nervous system (CNS), [>]

  Central sulcus, [>]

  Cerebellum, [>], [>], [>]

  in musicians, [>]

  synapse in, [>]

  Cerebral cortex, [>]–[>]

  Cerebral lateralization, [>]

  Cerebrum, [>]–[>], [>]

  and brainstem death, [>]

  Chadwick, John, [>], [>]–[>]

  Change

  from brain rewiring, [>]–[>]

  question of possibility of, [>]–[>]

  See also Learning

  Changeux, Jean-Pierre, [>]

  Channelopathy, [>]

  Chemical message

  by hormones, [>]

  between human beings, [>]–[>]

 

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