"Stone, I read your columns in theSentinel. So I sort of feel like I've kept in contact. I can almost hear your voice sometimes."
"That makes me think you were cheating a little on our deal."
"Well," she heard herself say, "some of them were pretty good. Sometimes you sounded like you knew as much as a doctor."
"Don't flatter me excessively, or I might want to start believing you." He laughed. "But speaking of doctors, didn't you used to have some kind of heart issue? How is that these days?"
"You really want to know?"
"Maybe it might have something to do with why I'm calling. Best I recall, you never actually told me, even back when."
"Thank you for asking," she said. "I guess it's not much of a secret anymore, with me popping nitro every other day. I have a scarred valve, coronary stenosis, and it's not getting any better. I don't know what to do about it short of going to Lourdes for a miracle."
"I see," he said. Then he fell silent. Mercifully, he didn't come up with false bravado about revolutionary treatments and you never can tell, blah, blah, blah. Then he said, "So is that why you've enrolled in the clinical trials at the Dorian Institute? To be part of their work using stem cells?"
What!" How thehelldo you know about-"
"Hey, Ally, you know I can't divulge my sources. After I knew you, I grew up to be a real reporter. That was my grand plan, remember?"
"Then this may turn out to be a very short conversation. I have nothing to-"
"Okay, okay, let's start over." He paused and cleared his throat. "Ahem. Are you the Alexa Hampton who was formally entered about half an hour ago into the stage-three clinical trials for the National Institutes of Health being held by the Gerex Corporation? Or maybe I should play dumb and begin by asking if you've ever heard of them."
"Stone, why. . why are you asking me this?"
It was bizarre. How could he know? And wait a minute, what did he mean about enrolling? She hadn't enrolled in anything.
"Ally, I'm finishing a major-I hope-book about stem cell technology, and right now the world leader is the Gerex Corporation. I think, but I can't yet prove, that their Dorian Institute out in New Jersey is the site of some pretty incredible stuff. I was … fooling around on the Internet, on the NIH Web site, looking for information about them, and-it must have been some momentary computer glitch-someone with your name popped up for a second. Along with a Nina Hampton. Which made me suspect it was you."
She was incredulous. She was being entered into the clinical trials before she had even seen the place? Somebody was pushing the pace. Winston Bartlett or Van de Vliet had taken it for granted that she and her mother would enter the trials. Worst of all, it took a former lover she hadn't talked to in x-zillion years to give her this unnerving information.
"Nina is your mom, right?" he went on. "I still remember her fondly. I don't think she thought much of me, however. By the way, how is she?"
"She's. . she's not doing all that great." Ally was still trying to get her mind around what she'd just heard. "But why are you calling me, Stone?"
"If anything I've said rings a vague bell, then could we meet someplace and talk? I don't think it would be a great idea to do it over the phone. That's all I really can say now."
Maybe, she thought, Stone Aimes might have uncovered a few things of which she ought to be aware. His pieces in theSentinelshowed he was a damned good reporter.
"I don't think what little I know about Gerex would be any help to you." She was attempting to get her mind back together. "I actually have a lot of questions about the stem cell procedure myself. I spoke on the phone just now with Dr. Van de Vliet and he described their technology to me in general terms. But maybe I should interview you. Maybe you could explain it to me using that wonderful gift you have for simplification in your columns."
"Ally, I don't know anything except what's in the public domain. They're privately held, so they don't have to tell anybody zilch. I assume you've actually been out to the Dorian Institute, which is more than I can say."
"Never."
"But you're enrolled-"
"I'm notenrolledin anything." To say the least. "And it bothers me that anybody thinks so. But Iamthinking about taking Mom out there tomorrow, if she still wants to go. When I talked to him on the phone, Dr. Van de Vliet wanted me to start the procedure immediately. That's scary, but he does seem to know what he's doing."
"I take it, then, that you're leaning toward going through with it."
She hated the way he'd just made her sound so gullible.
"The truth is, I'm more concerned for Mom. He claims he can help her early-onset Alzheimer's, and that would mean a lot." Why was she telling him all this stuff? She found herself wondering if he'd ever married.
"I'm so sorry to hear that. But the chances are he can."
"What are you thinking?" she asked finally. "And why did you call me? Really?What'sgoing on?"
"I don't know yet. There's a lot I don't know." He seemed to hesitate. "Ally, is there any chance whatsoever that-while you're out there-you could get me the names of some of the
people who've been through the clinical trials? The Dorian Institute is entirely off-limits to the press. I tried several times to schedule an interview with Karl Van de Vliet, the guy you talked to, but no luck. I can't get past the corporate people. My only hope is to try and find some patients who've been treated and released who've completed the clinical trials. But Gerex has been ruthless about keeping their identities secret You are literally the first person I've found who has any connection with the institute and is willing to talk about it. That is,ifyou're willing."
"Stone, it would be like the blind leading the blind. I don't know the first thing about the place."
"Well, let me ask you this-when you were talking with him, did Van de Vliet happen to mention any occasion where a subject had been terminated from the trials?"
"It never came up. Why do you-?"
"Never mind. But when and if you go out there, you might inquire about that." He paused. "Don't get me wrong. I'm actually Gerex's biggest fan. I mean, considering merely what you told me, that they're claiming to have a procedure that treats early-onset Alzheimer's. Think about it. I'm rooting for your mom, sure, but that's a Nobel Prize in itself, right there. We're talking major medical history in the making."
"And?"
"AndI want to publish the first book about it." He paused. "Also, a little birdie tells me that something not entirely kosher may be going on out there. No proof, just a reporter's hunch. There's a little too much sudden secrecy."
Ally was having a strange feeling come over her. She was actually enjoying talking to him.
"Shit, Stone, I'm glad you called. I lost two men I loved very much since I knew you and I'm feeling very alone at the moment. I could use some moral support I've got a lot of people bugging me to enter those clinical trials. Even people I'd never met before, like Winston Bartlett, the New York big shot. He's suddenly very concerned about my health. I have no idea what that's about. But it makes me uneasy."
There was an awkward lull, then, "Ally, all I'm asking is that you just take the measure of the Dorian Institute when you're out there and tell me what you think about the place. Are they performing the miracles they announced as their objective?"
"Look, I'll help you when and if I actually can. So give me your number, okay?"
He did.
"I can tell when I'm being blown off," he went on. "I have a very sensitive blow-off detector. But why don't you try a test? When you're out at the institute, ask Van de Vliet or somebody why that mystery patient was terminated from the clinical trials. See if the question makes them uncomfortable."
"Why does that matter so much to you?"
"If a patient is dropped for no good reason about the same time they clamp down on information, I think it could be fishy. Beyond that, I cannot speculate. And while you're at it, I'd love the names of some other ex-patients. Anybody. I found a list on the NIH
Web site but they're all encoded, so it doesn't do me any good. I just want to ask them if the procedure worked or not. It's information that's going to be made public eventually, no matter what. Come on, Ally, don't you want some testimonials?"
"Okay, look, I'll try to see if anybody there will give me any info."
She was realizing she was in a comfort zone when she was talking to him. Still, so much about him remained a mystery. He had always said his mother and father were both dead, but it was still suspiciously hard to get him to speak about them. She'd gotten the impression that he didn't actually remember his father. That was the part of his life that he'd always been the most closed off about. Either that or he was repressing some horrible memories.
"Thanks a lot, Ally." A pause, then, "Interested in getting together sometime?"
"Let me think about it."
She put down the phone with her mind in turmoil. She realized she hadn't asked him if he was "attached" but the next time they spoke, she was going to try to ease it into the conversation.
Chapter 12
Tuesday, April 7
9:50a.m.
Ally steered her Toyota onto the ramp leading to the George Washington Bridge, the entryway to northern New Jersey. She was just finishing a phone call to Jennifer. She wanted her to take a look at the notes and blueprints for Bartlett's Gramercy Park project and scan them into their CAD program. After all the phone calls yesterday, she'd been too sidetracked to do it. Although Bartlett had declared he wasn't in any hurry, he had messengered a certified check to her office Monday afternoon. The project was a go. She wanted to get moving while everything was fresh in her mind.
Before leaving her apartment this morning, she'd downloaded a map from MapQuest and from it she had estimated that the drive up to the Dorian Institute would be approximately an hour-give or take. She had begun the trip early because her mother's mind had been lucid the previous evening and she was hoping that interlude might last into this morning.
Unfortunately, it had not.
Nina was sitting next to her now, in full makeup but completely unresponsive, seemingly in another world. When Ally arrived at the Riverside Drive apartment to pick her up, Maria-now silent and uneasy in the backseat, reading a Spanish novel-met her at the door with a troubled look and shook her head sadly.
"Miss Hampton, I know she was all right when you were here last night, but this morning … she may not recognize you. She'll most likely snap out of it and be okay later on, but right now she's just in a fog. It was all I could do to get her ready."
When Ally walked in, Nina was sitting in her favorite chair, dressed in her favorite black suit. Her makeup was perfect.Thank you, Maria.
"Hey, sweetie, you look great."
Nina stared at her as though trying to place the face and said nothing. She just looked confused and very, very sad.
Dear God, Ally thought,this is the first time she's completely failed to recognize me.
It was so disheartening. Last night, when Ally had come up to discuss whether or not she still wanted to explore Dr. Van de Vliet's experimental treatment, Nina had been completely cognizant. Ally had tried to explain the concept of neural tissue regeneration using stem cells, which was difficult since she barely understood it herself.
"Mom," she had said "this might be something that could reverse some of the damage to your… memory. At least keep it from getting worse. I know it sounds scary but everybody says the conventional treatments for what you have don't work very well or very long."
"Then let's go out there and talk to him, honey. Just come in the morning and take me. By then I'll probably forget everything you've said tonight."
How prescient, Ally thought sadly. Now Nina was just gazing blankly ahead, silent. Does she remember anything from last night?
For that matter, whatwasNina thinking now? Was she conscious of the fact she was losing her mind? And what about the ultimate question: do we want to live longer merely to be alive, or do we want to stay alive in order to do things? To be or to do? In her mother's case, she knew it was the latter. Nina had always been full of life, ambition, and projects. Would she want to go on living if none of those things were possible? You never know for sure about other people, even your own mother, but Ally suspected she would rather not live to see that day.
Now, though, was she even aware it was coming?
Ally thought back about the first signs. Nina hadn't yet turned sixty-five when she abruptly started having trouble remembering little things. She began forgetting where she'd put items, and she gave up on remembering phone numbers and dates. Initially it had just seemed like a lot of "senior moments" run together, very puzzling.
But then it got worse. She'd always loved music, and she'd always played the piano. She loved Chopin, especially the nocturnes. By the time she was sixty-six, however, she was having trouble remembering the names of her favorite composers. She also completely gave up trying to play, either from memory or with the music. When getting dressed one day, she put on her blouse completely backwards. It was bad.
Ally had taken her to see four different specialists and they all had concluded that Nina Hampton suffered from what was known as familial early-onset Alzheimer's. It was caused by a mutated gene and was extremely rare, representing only some 5 percent of all Alzheimer's cases.
There were two major drugs currently on the market, Exelon and Reminyl, that could relieve some of the symptoms of Alzheimer's by boosting the action of the brain chemical acetylcholine. However, Nina had not yet declined to the stage where doctors would prescribe those drugs. To resort to them was an admission you were at endgame, since they usually were effective only for a few months.
So the Dorian Institute might well be a long shot worth taking. Frankly, what's to lose?
This morning, she knew, was going to be difficult. If Nina
wanted to stay and checked in, there would surely be a pile of paperwork. Ally had had the foresight to acquire power of attorney for her mother three months earlier, and she'd brought along that document in case it might be needed. And Maria, the wonderful, ultimate caregiver, was there to help. The real challenge, however, might well be trying to help Nina understand what was going on and participate in the decision. This was the moment every child dreads, when you have to face, really face, a parent's mortality.
As the green forests of northern New Jersey began to envelop them, she slipped a CD of Bach partitas for unaccompanied violin into the CD player. She had loved to play them all her life, but now Dr. Ekelman had urged her to put her violin into storage. Hearing the violin now reminded her of the other purpose of the trip, the treatment decision she needed to make forherself.
In that regard one of the things that kept running through her mind was what Stone Aimes had said about the Gerex Corporation instituting a news blackout simultaneously with a patient being mysteriously dropped from the trials. Those concurrent facts did not need to be ominous, but they also could use an explanation.
What was she going to do? Was Van de Vliet's stem cell procedure on her heart really worth the risk? She honestly didn't know. Even though the violin had temporarily been taken away from her, she had hopes she could gradually get it back. There were other ways to try to strengthen a dysfunctional heart.
Well, she thought, wait and hear him out.
From the George Washington Bridge she had taken I-4, which turned into I-208 and now the green forest held sway. It felt like she'd gone through a time warp, from the beginning of the twenty-first century to the end of the eighteenth. Then finally, as the second partita was ending, the icy-cold Greenwood Lake came into view. It was associated with those long Finger Lakes gouged out by glaciers.
Driving past remnants of the last Ice Age, she reflected on how insignificant humans are in the scheme of things. Suddenly she thought of Aldous Huxley's novelAfter Many a Summer Dies the Swan, about a wealthy madman who'd discovered a way to prolong life by eating the entrails of prehistoric fish. Maybe it was seeing th
e lake that made her flash on that.
She was now on Greenwood Lake Road, which passed around the west side, and there were numbers on several gated driveways as she passed along. She suspected the place would be somewhere along the middle of the lakeshore, and she was right.
After a few miles she came to a discreet sign announcing the Dorian Institute, and a large iron gate that protected a paved roadway leading into a forest of trees. That was it: just forest, no hint of a building, though she saw signs of some kind of industrial park farther down the road. When she drove up to the gate, she realized there was a video camera and a two-way intercom.
When she reached out of the window and pushed the talk button, she heard "Good morning." And then the gates parted in the middle and slid back.
They must be expecting us, she thought, and drove through.
The road was cobblestone, or rough paving brick. It wound among the trees for approximately half a mile and then widened.
There, framed by the lake in the background, was a magnificent three-story building with eight Doric columns across the front in perfect Greek Revival style. There were windows at ground level, but they were heavily curtained.
Built of red brick, the building probably dated from the late nineteenth century, and it looked every bit like an Ivy League dormitory.
"Miss Hampton, I don't like the feeling I'm getting about this place," Maria said quietly. "It is very cold and formal from the outside, but inside I sense a place where there is bad magic. In the Dominican Republic, we call it Santeria. I can always tell these things."
Ally knew and respected Maria's sixth sense. But then Maria sometimes still acted like a freshly minted citizen just off a green card, and she had an innate suspicion of authority- evoking buildings. Her aversion to the Dorian Institute might be nothing more than that.
On the other hand, Ally was having a bit of the same feeling. There was something formidable and foreboding about the place that seemed out of keeping with its supposedly benign purpose. She felt a moment of tightness in her chest.
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