by Dave Asprey
and bakuchiol, 238
and cryotherapy, 236–37
and GHK, 229
and laser facials, 239–40
from light therapy, 94–95
and melanin, 240
and methylene blue, 238–39
and microneedling, 237
in pig’s ears, 56–57
as protein powder, 48, 201, 234, 246
red light for stimulating production, 92–93
and retinol, 238
and vampire facials, 237
vitamin C for production of, 7
compact fluorescent light (CFL) bulbs, 78, 81, 132
conjugated linoleic acid (CLA), 53
Cook, Matthew, 223, 224
copper, 34, 130, 136
copper orotate supplements, 136
copper peptides (GHK-Cu), 229–30, 231, 249
cortisol, 70, 164, 171, 175
Crohn’s disease, 252, 259
cryofacials, 236
cryotherapy, 236–37
curcumin/turmeric, 80, 126–27, 219
cyclical ketogenic diet, 114–15, 128
cypress essential oil, 225, 231
cytokines, 10, 13, 17, 175, 177
cytomaxes and cytogens, 249–50
DAO (diamine oxidase) enzyme, 192
death, human avoidance of, xiv, xv–xvii
death by a thousand cuts
overview, 6, 20, 26, 101
and brain function, 107–8
defense strategy, 10, 96–97, 101
inflammation factor, 108–9
and mitochondria, 8–9, 108, 232
sleep for recovery from, 67, 77
dehydroepiandrosterone (DHEA), 158, 162–63, 173
delta (deep) sleep, 69–71, 74, 77–78
dementia. See cognitive dysfunction
de novo lipogenesis, 50
dental health hacks, 180–83. See also teeth
deprenyl (selegiline), 122–23
depression, 199
detoxing, 133–34, 142. See also heavy metal detox methods; waste buildup inside cells
DHEA (dehydroepiandrosterone), 158, 162–63, 173
DHT (dihydrotestosterone), 168–69, 242, 245, 246
diabetes, 4, 5, 13–17, 87
diabetes, type 2, 12–13, 33, 194. See also insulin resistance
diabetes, type 3, 14. See also Alzheimer’s disease
Diabetes (journal), 32
diamine oxidase (DAO) enzyme, 192
diet
anti-inflammatory, low in sugar, 183
calorie restriction, 15, 154, 219
cyclical ketogenic diet, 114–15, 128
heart healthy, low-fat, low-cholesterol, 166–67
limiting eating window to 6–10 hours, 49, 60–61, 62, 154, 155
polyphenols and antioxidants, 246
protein restriction, 47–49
raw ominvore, 46
reducing the effect of carbohydrates, 113, 128
relationship to health, 14–15
vegan, 45–47
Western diet, 166–67
See also fasting; food
digestive fiber, 138–39
dimmer switches for lights, 79, 81, 90
dismutase, 127
DMC (dimethoxychalcone), 30
DNA, 152, 200
DNA Company, 23
dopamine, 122–23, 127, 172
Ebola epidemic, Sierra Leone, Africa, 148–49
eczema, 177
ED (erectile dysfunction), 121, 213, 220–22
EDTA (ethylenediaminetetraacetic acid) chelation therapy, 139–41
EEG (electroencephalogram), 69, 105–7
electrical stimulation pill, 191
electron shuffling with NAD, 151–54
embryonic stem cells, 209–10
emotional stress, inflammation from, 34
endocrine system, IVL therapy for, 96
End of Alzheimer’s, The (Bredesen), 104
endothelium, 10
energy and protein, 48
energy fats, 55–61
energy increases, 6. See also mitochondrial energy
Enig, Mary, 51–52
environment
evergreen trees, 225, 231
hormone-disrupting chemicals, 167–68
toxic mold exposure effects, 3, 5, 8, 12–13, 20, 225
See also death by a thousand cuts
enzymes, 122–23, 127, 192, 241
Eos and Tithonus, 265
epigenetic mechanisms, mitochondrial, 27
Epitalon, 38, 249
erectile dysfunction (ED), 121, 213, 220–22
estrogen, 158–59, 168
“eternal life” quest, xiv
evergreen tree aromatic compounds, 225, 231
EverlyWell, 32–33, 203
exercise
addictive nature of, 121
for boosting testosterone levels, 173
choosing based on how well you slept, 83
detoxing by sweating during, 141–42
high-intensity interval training, 141–42, 170–71
and hormones, 170–71
for increasing Klotho levels, 228
Kegels, 222
for preventing telomere shortening, 38
and SARMS, 257–59
weight lifting, 219
exosomes, 215–16
extracellular aggregates, 33–35
extracellular matrix stiffening, 31–33
fasting
overview, 49
for breaking down amyloids, 34
and fasting-induced adipose factor, 197
for heavy metal detox, 142
for increasing NAD+ levels, 154
intermittent fasting, 49, 60–61, 62, 154, 155
limiting eating window to 6–10 hours, 49, 60–61, 62, 154, 155
and stem cells, 219
fasting-induced adipose factor (FIAF), 197
fats
overview, 50–55
energy fats, 55–61
and healthy testosterone levels, 166–67
omega-6 and omega-3, 50, 53–55, 62
replacing undesirable calories with saturated fats, 173
saturated fats, 50–52
types of, 51–52
fatty acids, 11–12, 48
fermented foods, 192, 193, 203
ferritin levels, 226
fertility, 170. See also bioidentical hormone replacement therapy; hormones
FIAF (fasting-induced adipose factor), 197
fiber
overview, 138
modified citrus pectin, 138–39
pairing carbohydrates with, 113, 128
prebiotic fiber, 193–95, 198–99, 201, 203
fibromyalgia, 259
field toxins, 42–43
fight-or-flight response on EEG, 106
fisetin, 30, 40
fish and heavy metals, 131
fluorescent lights, 86
flutathione, 134–36
food, 41–62
overview, 41
aging from, 69
Big Food and glyphosate, 44
energy fats, 55–61
fats, 50–55
fermented foods, 192, 193, 203
grains, gluten, glucose and glyphosate, 41–45, 62, 194–95, 201
industrially-raised animals, 12, 43–44, 47, 51, 201
nightshade sensitivity, 181, 201
pig’s ears for collagen, 56–57
See also diet; meat
food sensitivities, 34, 40, 198
Fountain of Youth, xvii
Four Killers, 3–23
overview, 4, 21, 22
and AGEs from fried or charred meat, 36, 40
and blue light exposure, 86–87
common underlying issue, 8–10
and mitochondria, 8–10
prebiotic fiber vs., 194
See also Alzheimer’s disease; cancer; diabetes; heart disease
Fowkes, Steven, 116
free radicals (reactive oxygen species)
overview,
7–8
from blue light exposure, 86
as byproduct of ATP production, 9
and cancer, 18
and mitochondrial mutations, 27–28, 35–36
ozone therapy vs., 151
PQQ vs., 124
released by MAO-B, 122
and senescent cells, 28
fried, blackened, and charred meat, 36–37, 40, 46, 54, 62
Fuller, Buckminster, 260–61
full-spectrum light, 86
GAINSWave shock-wave therapy, 221–22, 231
galectin-3 molecule, 139
Gallagher, Dr., 144
Game Changers (Asprey), 41
gamma waves, 70
Gartenberg, Daniel, 77–78
gastroesophageal reflux disease (GERD), 199, 235
genetics
functional genomics and risk, 22–23
genotoxins, 43
MITF gene, 241–42
mitochondrial DNA, 26–28
sequencing the human genome, 27, 102
genital stem cell therapy, 213, 214, 217, 220–21
genotoxins, 43
GERD (gastroesophageal reflux disease), 199, 235
germs, 185–203
microbes passed to you at birth, 189–91
microbiome, 185, 186, 187–88, 189–91, 192, 199, 200
See also bacteria; gut bacteria
GHK-Cu (copper peptides), 229–30, 231, 249
ghrelin, 64
glucosamine and mitochondrial biogenesis, 15
glucose and blue light, 86
glucosepane, 32
glutathione
overview, 135
breaking down hydrogen peroxide, 241
and cryotherapy, 236
and hair growth, 245
and heat shock proteins, 94
for heavy metal detox, 134–35, 143
vs. hydrogen peroxide buildup, 241
liver support, 31
and ozone therapy, 146
and steep temperature drops, 236
gluten sensitivity, 42
glycated albumin, 194
glycation, 31
glycine, 43, 234–36
glymphatic system, 65
glyphosate, 42–44, 201
grain, 42–43, 62, 201
grass-fed animal products
butter, 53, 55, 57
collagen, 48, 62, 201, 246
meats, 37, 167, 169–70, 173
as protein source, 47–48
switching to, 44
gray hair, reason for, 241
Greek mythology, xvii, 207, 227, 265
Greene, Robert, 1
green tea extract, 220
Grey, Aubrey de, 24
gut as an ecosystem, 186–87
gut bacteria, 185–203
overview, 186–89
and atherosclerosis, 11
bacterial fuel and the gut lining, 197–200
bifidobacteria, 198
and digestive fiber, 138–39
and obesity vs. thinness, 197
and parasites supplemented with helminth therapy, 187
plasmid level exchange among, 11–12
and resistant starch, 196–97, 203
transforming veggies into fatty acids, 48
gut-brain axis, 199–200
gut lining, 197–98, 234–35
gut microbes, 198
gut microorganisms, tracking your, 200–202
hacks. See biohackers; biohacking
hair, 127, 168–69, 229, 241–45, 246–47
halogen light, 82
Harvard Medical School, 111–12
Hashimoto’s thyroiditis, 5–6
Hayflick limit, 37
HCL (betaine hydrochloride), 235
head massages, 245, 247
healing and regeneration
Herodotus on Fountain of Youth, xvii
from inside out, 95, 232–33
See also multiple methods for strengthening your body
healing peptides, 250–52
heartburn, 235
heart disease
overview, 10–13
and atherosclerosis, 10–11, 172
incidence of, 4
inflammation as cause of, 10–12
and lead exposure, 131
senile cardiac amyloidosis, 33
and testosterone level, 159
heart health and activated charcoal, 137
heart rate variability (HRV), 71–73, 75
heavy metals, 34, 130–33
heavy metal detox methods, 133–42
overview, 133–34
activated charcoal, 136–38
chlorella, 138
citrus pectin, modified, and other fibers, 138–39
EDTA chelation therapy, 139–41
flutathione and other antioxidants, 134–36
sweat it out, 141–42
helminth therapy, 187
hemophilia, transfusions for, 226
herbs
ashitaba, 30
astragalus, 39
He Shou Wu, 127
stephania root, 127
See also brain herbs, supplements, and drugs; supplements
Herodotus, xvii
He Shou Wu (polygonum multiflorum), 127
HGH (human growth hormone), 165–66, 170–71
HIIT (high-intensity interval training), 141–42, 170–71
hippocampal atrophy, 25–26, 107
histamines and histamine intolerance, 191–93, 203
hormetic stress, 48–49, 145–46
hormones, 156–73
overview, 158
alpha-MSH, 240
cortisol, 70, 164, 171, 175
driving the aging process, 158–59
fasting-induced adipose factor, 197
ghrelin, 64
immune system support, 70
leptin, 64, 171
from L-tyrosine supplements, 171–72
melatonin, 64, 79, 85–86
modern living vs., 166–70
thyroid-stimulating hormone, 243–44
thyroxine, 243–44
work-up, 5–6, 156, 160–61, 173
See also bioidentical hormone replacement therapy
HRV (heart rate variability), 71–73, 75
human growth hormone (HGH), 165–66, 170–71
human nature
avoiding that which hurts, 26
death avoidance, xiv, xv–xvii
fight-or-flight response, 106
prioritizing survival over socialization, 13
hyaluronic acid, 217
hydrogen peroxide, 241
IBD (inflammatory bowel disease), 177, 199
IBS (irritable bowel syndrome), 199, 252
idebenone/coenzyme Q10, 123–24
IDE (insulin-degrading enzyme), 113, 115
immune system
and autoimmune diseases, 188
cytokines as immune response, 10, 13, 17, 175, 177
hormones that support, 70
infant to child development of, 190
IVL therapy for, 96
and modified NK cells, 223–25, 231
senescent cells of, 29
and telomere shortening, 37
incontinence, 220–22
induced pluripotent stem cells (iPSCs), 222, 223–24
industrially-raised animals, 12, 43–44, 47, 51, 201
infants’ microbiome, 189–91
infections
dental caps over low-grade infections, 144, 155
ozone therapy vs., 147–48
viral infections and gray hair, 241–42
inflammation
from AGEs, 31–32, 36, 45, 46, 112, 139
and amyloids, 34
from blue light, 86
and brain dysfunction, 108, 112–16
from cross-linked proteins, 32
and cytokines, 10, 13, 17, 175, 177
from dental caps over low-grade infections, 144, 155
effect of reducing, 16
from galectin-3 molec
ule, 139
and lipopolysaccharides, 198
from mitochondria dysfunction, 10
Naltrexone for, 260
from omega-6 fats, 53
from oxytocin decrease, 164
and plaque in arteries, 10–11, 50
from senescent cells, 28–29
and snoring, 69
and teeth, 174
from wheat-stimulated zonulin releases, 42
inflammatory bowel disease (IBD), 177, 199
infrared sauna, 94, 97, 141. See also red/infrared light
injections, self-administered, 251
Insilico Medicine, 186
insulin, 64, 112, 115, 256
insulin-degrading enzyme (IDE), 113, 115
insulin resistance, 29, 112–13, 196
insulin sensitivity, 115, 196–97
intracellular aggregation, 35–36
intravenous laser therapy (IVL), 95–96
ipRGCs (intrinsically photosensitive retinal ganglion cells), 79
iPSCs (induced pluripotent stem cells), 222, 223–24
iron, 130
irritable bowel syndrome (IBS), 199, 252
islet amyloid, 33
IVL (intravenous laser therapy), 95–96
IV NAD+ treatments, 153
IV sedation, 215
jaw alignment, 177–80, 184
Jennings, Dwight, 178
jet lag, 78
joint pain, prolozone for, 150, 155
Joovv red light therapy, 93
junk (blue) light, 78–82, 85–90, 97
junk buildup. See waste buildup inside cells
Kandel, Eric, 107
Keck School of Medicine, University of Southern California, 66–67
Kegel exercises, 222
ketones and ketosis
overview, 50–51
cyclical ketogenic diet for reducing risk of Alzheimer’s, 114–15, 128
inducing lipolysis, 142
and intermittent fasting, 60–61, 62
from MCT oil, 57–58, 183
in moderation, 33–34, 61
and NAD+ to NADH ratio, 154
KetoPrime supplement, 154
Khavinson, Vladimir, 249
kidney disease, 14, 43, 227
Killen, Amy, 217
Klinghardt, Dietrich, 169
Klotho, 227–28
Kuro-o, Makoto, 227
Lana, Dr. See Asprey, Lana
Lancet, The (journal), 130–31, 194
laser facials, 239–40
laser for muscle soreness, 91–92
laser therapy
and central nervous system, 174–75
for cognitive dysfunction, 109–12
intravenous laser therapy, 95–96
for muscle soreness, 91–92
lead, 35, 130–33, 136, 141
leaky gut syndrome, 127, 198–99, 201, 234
lectins, 194
LEDs (light-emitting diodes), 78, 81
86, 86
leptin, 64, 171
Life Cykel lion’s mane extract, 126
light, 84–97
overview, 84, 97
beneficial sources, 91–96
blue/junk light, 78–82, 85–90, 97
and circadian rhythm, 84–85
dimmer switches for light sources, 79, 81, 90
infrared sauna, 94, 97