The Great Influenza
Page 44
The writers of the 1920s had little to say about it.
Mary McCarthy got on a train in Seattle on October 30, 1918, with her three brothers and sisters, her aunt and uncle, and her parents. They arrived in Minneapolis three days later, all of them sick (her father had pulled out a gun when the conductor tried to put them off the train) met by her grandparents wearing masks. All the hospitals were full and so they went home. Her aunt and uncle recovered but her father, Roy, thirty-eight years old, died on November 6, and her mother, Tess, twenty-nine years old, died November 7. In Memories of a Catholic Girlhood she spoke of how deeply being an orphan affected her, made her desperate to distinguish herself, and she vividly remembered the train ride across two-thirds of the country, but she said almost nothing of the epidemic.
John Dos Passos was in his early twenties and seriously ill with influenza, yet barely mentioned the disease in his fiction. Hemingway, Faulkner, Fitzgerald said next to nothing of it. William Maxwell, a New Yorker writer and novelist, lost his mother to the disease. Her death sent his father, brother, and him inward. He recalled, 'I had to guess what my older brother was thinking. It was not something he cared to share with me. If I hadn't known, I would have thought that he'd had his feelings hurt by something he was too proud to talk about' .' For himself, '[T]he ideas that kept recurring to me, perhaps because of that pacing the floor with my father, was that I had inadvertently walked through a door that I shouldn't have gone through and couldn't get back to the place I hadn't meant to leave.' Of his father he said, 'His sadness was of the kind that is patient and without hope.' For himself, 'the death of my mother' was a motivating force in four books.'
Katherine Anne Porter was ill enough that her obituary was set in type. She recovered. Her fiancé did not. Years later her haunting novella of the disease and the time, Pale Horse, Pale Rider, is one of the best (and one of the few) sources for what life was like during the disease. And she lived through it in Denver, a city that, compared to those in the east, was struck only a glancing blow.
But the relative lack of impact it left on literature may not be unusual at all. It may not be that much unlike what happened centuries ago. One scholar of medieval literature says, 'While there are a few vivid and terrifying accounts, it's actually striking how little was written on the bubonic plague. Outside of these few very well-known accounts, there is almost nothing in literature about it afterwards.'
People write about war. They write about the Holocaust. They write about horrors that people inflict on people. Apparently they forget the horrors that nature inflicts on people, the horrors that make humans least significant. And yet the pandemic resonated. When the Nazis took control of Germany in 1933, Christopher Isherwood wrote of Berlin: 'The whole city lay under an epidemic of discreet, infectious fear. I could feel it, like influenza, in my bones.'
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Those historians who have examined epidemics and analyzed how societies have responded to them have generally argued that those with power blamed the poor for their own suffering, and sometimes tried to stigmatize and isolate them. (The case of 'Typhoid Mary' Mallon, an Irish immigrant in effect imprisoned for twenty-five years, is a classic instance of this attitude; if she had been of another class, the treatment of her might well have been different.) Those in power, historians have observed, often sought security in imposing order, which gave them some feeling of control, some feeling that the world still made sense.
In 1918 what might be considered a 'power elite' did sometimes behave according to such a pattern. Denver Health Commissioner William Sharpley, for example, blamed the city's difficulties with influenza on 'foreign settlements of the city,' chiefly Italians. The Durango Evening Herald blamed the high death toll among Utes on a reservation on their 'negligence and disobedience to the advice of their superintendent and nurses and physicians.' One Red Cross worker in the mining regions of Kentucky took offense at uncleanliness: 'When we reached the miserable shack it seemed deserted' . I went on in and there laying with her legs out of the bed and her head thrown way back on a filthy pillow was the woman, stone dead, her eyes staring, her mouth yawning, a most gruesome sight' . The mother of the woman's husband came in, an old woman living in an indescribable shack some 300 feet away' . I can still smell the terrible odor and will never forget the nauseating sight. The penalty for filth is death.'
Yet, despite such occasional harshness, the 1918 influenza pandemic did not in general demonstrate a pattern of race or class antagonism. In epidemiological terms there was a correlation between population density and hence class and deaths, but the disease still struck down everyone. And the deaths of soldiers of such promise and youth struck home with everyone. The disease was too universal, too obviously not tied to race or class. In Philadelphia, white and black certainly got comparable treatment. In mining areas around the country, whether out of self-interest or not, mine owners tried to find doctors for their workers. In Alaska, racism notwithstanding, authorities launched a massive rescue effort, if too late, to save Eskimos. Even the very Red Cross worker so nauseated by filth continued to risk his own life day after day in one of the hardest-hit areas of the country.
During the second wave, many local governments collapsed, and those who held the real power in a community (from Philadelphia's bluebloods to Phoenix's citizens' committee) took over. But generally they exercised power to protect the entire community rather than to split it, to distribute resources widely rather than to guarantee resources for themselves.
Despite that effort, whoever held power, whether a city government or some private gathering of the locals, they generally failed to keep the community together. They failed because they lost trust. They lost trust because they lied. (San Francisco was a rare exception; its leaders told the truth, and the city responded heroically.) And they lied for the war effort, for the propaganda machine that Wilson had created.
It is impossible to quantify how many deaths the lies caused. It is impossible to quantify how many young men died because the army refused to follow the advice of its own surgeon general. But while those in authority were reassuring people that this was influenza, only influenza, nothing different from ordinary 'la grippe,' at least some people must have believed them, at least some people must have exposed themselves to the virus in ways they would not have otherwise, and at least some of these people must have died who would otherwise have lived. And fear really did kill people. It killed them because those who feared would not care for many of those who needed but could not find care, those who needed only hydration, food, and rest to survive.
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It is also impossible to state with any accuracy the death toll. The statistics are estimates only, and one can only say that the totals are numbing.
The few places in the world that then kept reliable vital statistics under normal circumstances could not keep pace with the disease. In the United States, only large cities and twenty-four states kept accurate enough statistics for the U.S. Public Health Service to include them in their database, the so-called registration area. Even in them everyone from physicians to city clerks was trying to survive or help others survive. Record keeping had low priority, and even in the aftermath little effort was made to compile accurate numbers. Many who died never saw a doctor or nurse. Outside the developed world, the situation was far worse, and in the rural regions of India, the Soviet Union (which was engaged in a brutal civil war) China, Africa, and South America, where the disease was often most virulent, good records were all but nonexistent.
The first significant attempt to quantify the death toll came in 1927. An American Medical Association-sponsored study estimated that 21 million died. When today's media refers to a death toll of 'more than 20 million' in stories on the 1918 pandemic, the source is this study.
But every revision of the deaths since 1927 has been upward. The U.S. death toll was originally put at 550,000. Now epidemiologists have settled on 675,000 out of a population of 105 million. In the year 2004, the U.S. populat
ion exceeds 291 million.
Worldwide, both the estimated toll and the population have gone up by a far greater percentage.
In the 1940s Macfarlane Burnet, the Nobel laureate who spent most of his scientific life studying influenza, estimated the death toll at 50 to 100 million.
Since then various studies, with better data and statistical methods, have gradually moved the estimates closer and closer to his. First several studies concluded that the death toll on the Indian subcontinent alone may have reached 20 million. Other new estimates were presented at a 1998 international conference on the pandemic. And in 2002 an epidemiological study reviewed the data and concluded that the death toll was 'in the order of 50 million,' [but] even this vast figure may be substantially lower than the real toll.' In fact, like Burnet, it suggested that as many as 100 million died.
Given the world's population in 1918 of approximately 1.8 billion, the upper estimate would mean that in two years (and with most of the deaths coming in a horrendous twelve weeks in the fall of 1918) in excess of 5 percent of the people in the world died.
Today's world population is 6.3 billion. To give a sense of the impact in today's world of the 1918 pandemic, one has to adjust for population. If one uses the lowest estimate of deaths (the 21 million figure) that means a comparable figure today would be 73 million dead. The higher estimates translate into between 175 and 350 million dead. Those numbers are not meant to terrify - although they do. Medicine has advanced since 1918 and would have considerable impact on the mortality rate (see Afterword). Those numbers are meant simply to communicate what living through the pandemic was like.
Yet even those numbers understate the horror of the disease. The age distribution of the deaths brings that horror home.
In a normal influenza epidemic, 10 percent or fewer of the deaths fall among those aged between sixteen and forty. In 1918 that age group, the men and women with most vitality, most to live for, most of a future, accounted for more than half the death toll, and within that group the worst mortality figures fell upon those aged twenty-one to thirty.
The Western world suffered the least, not because its medicine was so advanced but because urbanization had exposed its population to influenza viruses, so immune systems were not naked to it. In the United States, roughly 0.65 percent of the total population died, with roughly double that percentage of young adults killed. Of developed countries, Italy suffered the worst, losing approximately 1 percent of its total population. The Soviet Union may have suffered more, but few numbers are available for it.
The virus simply ravaged the less developed world. In Mexico the most conservative estimate of the death toll was 2.3 percent of the entire population, and other reasonable estimates put the death toll over 4 percent. That means somewhere between 5 and 9 percent of all young adults died.
And in the entire world, although no one will ever know with certainty, it seems more than just possible that 5 percent (and in the less developed countries approaching 10 percent) of the world's young adults were killed by the virus.
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In addition to the dead, in addition to any lingering complications among survivors, in addition to any contribution the virus made to the sense of bewilderment and betrayal and loss and nihilism of the 1920s, the 1918 pandemic left other legacies.
Some were good ones. Around the world, authorities made plans for international cooperation on health, and the experience led to restructuring public health efforts throughout the United States. The New Mexico Department of Public Health was created; Philadelphia rewrote its city charter to reorganize its public health department; from Manchester, Connecticut, to Memphis, Tennessee, and beyond, emergency hospitals were transformed into permanent ones. And the pandemic motivated Louisiana Senator Joe Ransdell to begin pushing for the establishment of the National Institutes of Health, although he did not win his fight until a far milder influenza epidemic in 1928 reminded Congress of the events of a decade earlier.
All those things are part of the legacy left by the virus. But the disease left its chief legacy in the laboratory.
Part X
ENDGAME
CHAPTER THIRTY-FOUR
BY WORLD WAR I, the revolution in American medicine led by William Welch had triumphed. That revolution had radically transformed American medicine, forcing its teaching, research, art, and practice through the filter of science.
Those in the United States capable of doing good scientific research remained a small, almost a tiny, cadre. The group was large enough to be counted in the dozens, and, counting the most junior investigators, by the mid-1920s it reached several dozen dozens, but no more.
They all knew each other, all had shared experiences, and nearly all had at least some connection to the Hopkins, the Rockefeller Institute, Harvard, or to a lesser extent the University of Pennsylvania, the University of Michigan, or Columbia. The group was so small that it still included the first generation of revolutionaries, with Welch and Vaughan and Theobald Smith and a few others still active. Then came their first students, men only a few years younger: Gorgas, who had reached mandatory retirement age from the army days before the war ended (the army could have allowed him to remain but he had no friends among army superiors) and who then shifted to international public health issues for a Rockefeller-funded foundation; Flexner and Park and Cole in New York; Milton Rosenau in Boston; Frederick Novy at Michigan; and Ludwig Hektoen in Chicago. Then came the next half generation of protegés: Lewis in Philadelphia; Avery, Dochez, Thomas Rivers, and others at Rockefeller; George Whipple in Rochester, New York; Eugene Opie at Washington University in St. Louis; and a few dozen more. It was only in the next generation, and the next, that the numbers of true researchers began to multiply enormously and spread throughout the country.
The bonds that held these men together were not of friendship. Some of them (Park and Flexner, for example) had no love for each other, many had happily embarrassed a rival by finding flaws in his work, and they had no illusions about each other's virtues. The profession had grown large enough for maneuvering within it. If one listened closely, one could hear: 'The appointment of Dr. Opie as the primary key man in this plan would be a fatal mistake.' Or, 'Jordan seems at first a rather dazzling possibility, but I am a little afraid' that he is not a man who can be absolutely certain to stand up for his convictions in a tight place.' Or, 'Of the names you suggest, I would distinctly prefer Emerson but I fear he would be particularly unacceptable to Russell and Cole, and perhaps to the [Rockefeller] Foundation group in general, as I have the impression that he has been somewhat at outs with them.'
Yet these men also recognized that whatever each other's flaws might be, each of them also had strengths, remarkable strengths. Their work was good enough that, even if in error, one could often find in that error something new, something important, something to build upon. It was an exclusive group and, despite rivalries and dislikes, almost a brotherhood, a brotherhood that included a very few women, literally a handful, and in bacteriology these very few women did not extend far beyond Anna Williams and Martha Wollstein.*
All of these scientists had worked frenetically in their laboratories from the first days of the disease, and none of them had stopped. In those most desperate of circumstances, the most desperate circumstances in which they (and arguably any scientist) ever worked, most of them had willingly, hopefully, accepted less evidence than they would normally have to reach a conclusion. For of course as Miguel de Unamuno said, the more desperate one is, the more one hopes. But for all their frenzy of activity, they had still always avoided chaos, they had always proceeded from well-grounded hypotheses. They had not, as Avery said with contempt, poured material from one test tube into another. They had not done the wild things that had no basis in their understanding of the workings of the body. They had not given quinine or typhoid vaccine to influenza victims in the wild hope that because it worked against malaria or typhoid it might work against influenza. Others had done these things and mo
re, but they had not.
They also recognized their failures. They had lost their illusions. They had entered the first decades of the twentieth century confident that science, even if its victories remained limited, would triumph. Now Victor Vaughan told a colleague, 'Never again allow me to say that medical science is on the verge of conquering disease.' With the contempt one reserves for one's own failings, he also said, 'Doctors know no more about this flu than 14th century Florentine doctors had known about the Black Death.'
But they had not quit. Now this scientific brotherhood was beginning its hunt. It would take longer than they knew.
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So far each laboratory had been working in isolation, barely communicating with the others. Investigators had to meet, to trade ideas, to trade laboratory techniques, to discuss findings not yet published or that one investigator thought unimportant that might mean something to another. They had to try to piece together some way to make concrete progress against this pestilence. They had to sift through the detritus of their failures for clues to success.
On October 30, 1918, with the epidemic on the East Coast fading to manageable proportions, Hermann Biggs organized an influenza commission of leading scientists. Biggs had a proud history, having made the New York City municipal health department the best in the world, but, fed up with Tammany politics, had left to become state commissioner of public health. His commission included Cole, Park, Lewis, Rosenau, epidemiologists, and pathologists. Welch, still recovering in Atlantic City, was too ill to attend. Biggs opened the first meeting by echoing Vaughan: '[T]here has never been anything which compares with this in importance' in which we were so helpless.'
But unlike Vaughan he was angry, declaring their failures 'a serious reflection upon public health administration and work and medical science that we should be in the situation we now are.' They had seen the epidemic coming for months. Yet public health officials and scientists both had done nothing to prepare. 'We ought to have been able to obtain all the scientific information available now or that can be had six months from now before this reached us at all.'