The Paleo Diet

by Cordain, Loren

  Larsen CS, Schoeninger MJ, van der Merwe NJ, Moore KM, Lee-Thorp JA. Carbon and nitrogen stable isotopic signatures of human dietary change in the Georgia Bight. Am J Phys Anthropol 1992;89:197-214.

  Lee RB, Daly RH (eds.). The Cambridge Encyclopedia of Hunters and Gatherers. Cambridge, UK: Cambridge University Press, 1999.

  Lee-Thorp J, van der Merwe NJ, Brain CK. Diet of Australopithecus robustus at Swartkrans from stable isotopic analysis. J Hum Evol 1994;27:361-372.

  Legge AJ, Rowley-Conway PA. Gazelle killing in stone age Syria. Sci Am 1988; 257:88-95.

  Legro RS. Polycystic ovary syndrome: current and future treatment paradigms. Am J Obstet Gynecol 1998;179(6 Pt 2) :S101-S108.

  Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC, Giovannucci EL. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr 2004;80(1):204-216.

  Lemann J, Lennon EJ. Role of diet, gastrointestinal tract and bone in acid-base homeostasis. Kidney Int 1972;1:275-279.

  Leonard WR, Robertson ML. Evolutionary perspectives on human nutrition: the influence of brain and body size on diet and metabolism. Am J Hum Biol 1994;6:77-88.

  Lewin R. A revolution of ideas in agricultural origins. Science 1988;240: 984-986.

  Liao F, Folsom AR, Brancati FL. Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 1998;136:480-490.

  Lieb CW. The effects on human beings of a twelve months’ exclusive meat diet. JAMA 1929;93:20-22.

  Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W. Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice. Urology 2002;60(5):919-924.

  Lindeberg S, Lundh B. Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: a clinical study in Kitava. J Intern Med 1993;233(3):269-275.

  Lindgren BF, Segovia B, Lassarre C, Binoux M, Gourmelen M. Growth retardation in constitutionally short children is related both to low serum levels of insulin-like growth factor-I and to its reduced bioavailability. Growth Regul 1996;6:158-164.

  Lindseth G, Lindseth PD. The relationship of diet to airsickness. Aviat Space Environ Med 1995;66:537-541.

  Lipkin M, Newmark HL. Vitamin D, calcium and prevention of breast cancer: a review. J Am Coll Nutr 1999;18(suppl 5):392S-397S.

  Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM, Cohen P. Direct functional interaction between insulin-like growth factor-binding protein-3 and retionoid X receptor-alpha regulate transcriptional signaling and apoptosis. J Biol Chem 2000;275:33607-33613.

  Liu S, Willett WC, Stampfer MJ, Hu FB, Franz M, Sampson L, Hennekens CH, Manson JE. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in U.S. women. Am J Clin Nutr 2000;71:1455-1461.

  Long C, Alterman T. Meet the real free-range eggs. Mother Earth News, 2007, MotherEarthNews.com, www.motherearthnews.com/Real-Food/2007-10-01/Tests-Reveal-Healthier-Eggs.aspx.

  Lopez-Bote CJ. Effect of free-range feeding on omega-3 fatty acids and alpha-tocopherol content and oxidative stability of eggs. Anim Feed Sci Technol 1998;72:33-40.

  Lorenz K. Cereals and schizophrenia. Adv Cereal Sci Technol 1990;10:435-469.

  Ludwig DS. Dietary glycemic index and obesity. J Nutr 2000;130:280S-283S.

  Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics 1999; 103:E26.

  MacDonald ML, Rogers QR. Nutrition of the domestic cat, a mammalian carnivore. Ann Rev Nur 1984;4:521-562.

  Mancilha-Carvalho JJ, Crews DE. Lipid profiles of Yanomamo Indians of Brazil. Prev Med 1990;19:66-75.

  Mann NJ, Li D, Sinclair AJ, Dudman NP, Guo XW, Elsworth GR, Wilson AK, Kelly FD. The effect of diet on plasma homocysteine concentrations in healthy male subjects. Eur J Clin Nutr 1999;53:895-899.

  Marean CW, Assefa Z. Zooarchaeological evidence for the faunal exploitation behavior of neanderthals and early modern humans. Evol Anthropol 1999; 8:22-37.

  Marks BL, Rippe JM. The importance of fat free mass maintenance in weight loss programmes. Sports Med 1996;22:273-281.

  Marmer WN, Maxwell RJ, Williams JE. Effects of dietary regimen and tissue site on bovine fatty acid profiles. J Anim Sci 1984;59:109-121.

  Martin-Moreno JM, Willett WC, Gorgojo L, Banegas JR, Rodriguez-Artalejo F, Fernandez-Rodriguez JC, Maisonneuve P, Boyle P. Dietary fat, olive oil intake and breast cancer risk. Int J Cancer 1994;58:774-780.

  Mason SLR, et al. Preliminary investigation of the plant macro-remains from Dolni Vestonice II, and its implications for the role of plant foods in Palaeolithic and Mesolithic Europe. Antiquity 1994;68:48-57.

  Mathews-Roth MM, Krinsky NI. Effect of dietary fat level on UV-B induced skin tumors, and anti-tumor action of b-carotene. Photochem Photobiol 1984;40: 671-673.

  Meat and Livestock Association of Australia (www.mla.com.au/).

  Medeiros LC, Belden RP, Williams ES. Selenium content of bison, elk and mule deer. J Food Sci 1993;4:731-733.

  Meneely GR, Battarbee HD. High sodium-low potassium environment and hypertension. Am J Cardiol 1976;38:768-785.

  Mertz JR, Wallman J. Choroidal retinoic acid synthesis: a possible mediator between refractive error and compensatory eye growth. Exp Eye Res 2000;70: 519-527.

  Metlapally R, Ki CS, Li YJ, Tran-Viet KN, Abbott D, Malecaze F, Calvas P, Mackey DA, Rosenberg T, Paget S, Guggenheim JA, Young TL. Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. Invest Ophthalmol Vis Sci 2010. (Epub ahead of print.)

  Meyer C, Mueller MF, Duncker GI, Meyer HJ. Experimental animal myopia models are applicable to human juvenile-onset myopia. Surv Ophthalmol 1999;44 (suppl 1):S93-S102.

  Mezzano D, Munoz X, Martinez C, Cuevas A, Panes O, Aranda E, Guasch V, Strobel P, Munoz B, Rodriguez S, Pereira J, Leighton F. Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine. Thromb Haemost 1999;81:913-917.

  Mickleborough TD, Gotshall RW, Rhodes J, Tucker A, Cordain L. Elevating dietary salt exacerbates leukotrienes-dependent hypernea-induced airway obstruction in guinea pigs. J Appl Physiol in press.

  Mikkelsen PB, Toubro S, Astrup A. Effect of fat-reduced diets on 24-hr energy expenditure: comparisons between animal protein, vegetable protein, and carbohydrate. Am J Clin Nutr 2000;72:1135-1141.

  Miller GJ, Field RA, Riley ML. Lipids in wild ruminant animals and steers. J Food Qual 1986;9:331-343.

  Miller MM. Low sodium chloride intake in the treatment of insomnia and tension states. JAMA 1945;129:262-266.

  Miller WC, Koceja DM, Hamilton EJ. A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord 1997;21:941-947.

  Milton K. Primate diets and gut morphology: implications for hominid evolution. In: Harris M, Ross EB (eds.), Food and Evolution. Philadelphia: Temple University Press, 1987, pp. 93-108.

  ————. Diet and primate evolution. Sci Am 1993;269:86-93.

  Moan J, Dahlback A, Setlow RB. Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation. Photochem Photobiol 1999;70:243-247.

  Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991-1998. JAMA 1999;282:1519-1522.

  Moore WJ, Corbett ME. Distribution of dental caries in ancient British populations. I. Anglo-Saxon period. Caries Res 1975;9:163-175; IV. The 19th century. Caries Res 1976;10:401-414.

  Morrow WJ, Yang YW, Sheikh NA. Immunobiology of the Tomatine adjuvant. Vaccine 2004 23;22(19):2380-2384.

  Moseson M, Koenig KL, Shore RE, Pasternack BS. The influence of medical conditions and associated hormones on the risk of breast cancer. Int J Epidemiol 1993;22:1000-1009.

  Movius HL. A wooden spear of third interglacial age from lower Sax
ony. Southwest J Anthropol 1950;6:139-142.

  Munger RG, Cerhan JR, Chiu BC. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr 1999;69: 147-152.

  Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA 1999;282: 1523-1529.

  Mutti DO, Zadnik K, Adams AJ. Myopia. The nature vs. nurture debate goes on. Invest Ophthalmol Vis Sci 1996;37:952-957.

  Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC, Huh KB. Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes Relat Metab Disord 1997;21:355-359.

  National Center for Health Statistics. The Third National Health and Nutrition Survey, 1988-94. Washington, DC: U.S. Department of Health and Human Services, 2000.

  Neel JV. Health and disease in unacculturated Amerindian populations. Ciba Found Symp 1977;49:155-177.

  Nelson GJ, Schmidt PC, Kelley DS. Low-fat diets do not lower plasma cholesterol levels in healthy men compared to high-fat diets with similar fatty acid composition at constant caloric intake. Lipids 1995;30:969-976.

  Nestler JE. Insulin regulation of human ovarian androgens. Hum Reprod 1997; 12(suppl 1):53-62.

  Nieman DC. Exercise Testing and Prescription. A Health Related Approach. London: Mayfield Publishing, 1999.

  Norrish AE, Skeaff CM, Arribas GL, Sharpe SJ, Jackson RT. Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control study. Br J Cancer 1999;81(7):1238-1242.

  Nuttall FQ, Gannon MC. Plasma glucose and insulin response to macronutrients in nondiabetic and NIDDM subjects. Diabetes Care 1991;14:824-838.

  Obarzanek E, Velletri PA, Cutler JA . Dietary protein and blood pressure. JAMA 1996;275:1598-1603.

  Obeid OA, Mannan N, Perry G, Iles RA, Boucher BJ. Homocysteine and folate in healthy east London Bangladeshis. Lancet 1998;352:1829-1830.

  O’Bryne DJ, O’Keefe SF, Shireman RB. Low-fat monounsaturated-rich diets reduce susceptibility of low density lipoproteins to peroxidation ex vivo. Lipids 1998;33:149-157.

  O’Dea K, Traianedes K, Ireland P, Niall M, Sadler J, Hopper J, De Luise M. The effects of diet differing in fat, carbohydrate, and fiber on carbohydrate and lipid metabolism in type 2 diabetes. J Am Diet Assoc 1989;89:1076-1086.

  Odeleye OE, de Courten M, Pettitt DJ, Ravussin E. Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian children. Diabetes 1997;46(8):1341-1345.

  Oh SY, Ryue J, Hsieh CH, Bell DE. Eggs enriched in omega-3 fatty acids and alterations in lipid concentrations in plasma lipoproteins and in blood pressure. Am J Clin Nutr 1991;54:689-695.

  Ohara N, Naito Y, Nagata T, Tatematsu K, Fuma SY, Tachibana S, Okuyama H. Exploration for unknown substances in rapeseed oil that shorten survival time of stroke-prone spontaneously hypertensive rats. Effects of super critical gas extraction fractions. Food Chem Toxicol 2006; 44(7):952-963.

  Ohara N, Naito Y, Nagata T, Tachibana S, Okimoto M, Okuyama H. Dietary intake of rapeseed oil as the sole fat nutrient in Wistar rats—lack of increase in plasma lipids and renal lesions. J Toxicol Sci 2008; 33(5):641-645.

  Ohara N, Naito Y, Kasama K, Shindo T, Yoshida H, Nagata T, Okuyama H. Similar changes in clinical and pathological parameters in Wistar Kyoto rats after a 13-week dietary intake of canola oil or a fatty acid composition-based interesterified canola oil mimic. Food Chem Toxicol 2009; 47(1):157-162.

  O’Keefe JH, Jr, Cordain L. Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21stcentury hunter-gatherer. Mayo Clin Proc 2004;79(1):101-108.

  Oliver WJ, Cohen EL, Neel JV. Blood pressure, sodium intake and sodium related hormones in the Yanomamo Indians, a “no-salt” culture. Circulation 1975; 52:146-151.

  Orengo IF, Black HS, Wolf JE. Influence of fish oil supplementation on the minimal erytherma dose in humans. Arch Dermatol Res 1992;284:219-221.

  Oshida Y, Yamanouchi K, Hayamizu S, Nagasawa J, Ohsawa I, Sato Y. Effects of training and training cessation on insulin action. Int J Sports Med 1991;12:484-486.

  Packard RR, Lichtman AH, Libby P. Innate and adaptive immunity in atherosclerosis. Semin Immunopathol 2009;31(1):5-22.

  Paleodiet Page, The. What Hunter-Gatherers Ate (www.paleofood.com).

  Pasquali R, Casimirri F, Vicennati V. Weight control and its beneficial effect on fertility in women with obesity and polycystic ovary syndrome. Hum Reprod 1997;12(suppl 1):82-87.

  Penny D, Steel M, Waddell PJ, Hendy MD. Improved analyses of human mtDNA sequences support a recent African origin for Homo sapiens. Mol Biol Evol 1995;12:863-882.

  Phinney SD, Bistrian BR, Evans WJ, Gervino E, Blackburn GL. The human metabolic response to chronic ketosis without caloric restriction: physical and biochemical adaptations. Metabolism 1983;32:757-768.

  Piatti PM, Monti F, Fermo I, Baruffaldi L, Nasser R, Santambrogio G, Librenti MC, Galli-Kienle M, Pontiroli AE, Pozza G. Hypocaloric high-protein diet improves glucose oxidation and spares lean body mass: comparison to hypocaloric high-carbohydrate diet. Metabolism 1994;43: 1481-1487.

  Pili R, Kruszewski MP, Hager BW, Lantz J, Carducci MA. Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis. Cancer Res 2001;61:1477-1485.

  Pitts GC, Bullard TR. Some interspecific aspects of body composition in mammals. In Body Composition in Animals and Man (Publication 1598). Washington, DC: National Academy of Sciences, 1968, pp. 45-70. Poikonen S, Puumalainen TJ, Kautiainen H, Burri P, Palosuo T, Reunala T, Turjanmaa K. Turnip rape and oilseed rape are new potential food allergens in children with atopic dermatitis. Allergy 2006;61(1):124-127.

  Poikonen S, Rancé F, Puumalainen TJ, Le Manach G, Reunala T, Turjanmaa K. Sensitization and allergy to turnip rape: a comparison between the Finnish and French children with atopic dermatitis. Acta Paediatr 2009;98(2):310-315

  Porrini M, Crovetti R, Riso P, Santangelo A, Testolin G. Effects of physical and chemical characteristics of food on specific and general satiety. Physiol Behav 1995;57:461-468.

  Porrini M, Santangelo A, Crovetti R, Riso P, Testolin G, Blundell JE. Weight, protein, fat, and timing of preloads affect food intake. Physiol Behav 1997; 62:563-570.

  Prentice AM. Manipulation of dietary fat and energy density and subsequent effects on substrate flux and food intake. Am J Clin Nutr 1998; 67(suppl 3):535S-541S.

  Price TD, Petersen EB. A Mesolithic camp in Denmark. Sci Am 1987;256:113-121.

  Prior IA, Davidson F, Salmond CE, Czochanska Z. Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies. Am J Clin Nutr 1981;34(8):1552-1561.

  Proctor CA, Proctor TB, Proctor B. Etiology and treatment of fluid retention (hydrops) in Meniere’s syndrome. Ear Nose Throat J 1992;71:631-635.

  Proud VK, Rizzo WB, Patterson JW, Meard GS, Wolf B. Fatty acid alterations and carboxylase deficiencies in the skin of biotin-deficient rats. Am J Clin Nutr 1990;51:853-858.

  Puumalainen TJ, Poikonen S, Kotovuori A, Vaali K, Kalkkinen N, Reunala T, Turjanmaa K, Palosuo T. Napins, 2S albumins, are major allergens in oilseed rape and turnip rape. J Allergy Clin Immunol. 2006;117(2): 426-432.

  Rajah R, Valentinis B, Cohen P. Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta 1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem 1997;272:12181-12188.

  Ramsden CE, Faurot KR, Carrera-Bastos P, Cordain L, De Lorgeril M, Sperling LS. Dietary fat quality and coronary heart disease prevention: a unified theory based on evolutionary, historical, global, and modern perspectives. Curr Treat Options Cardiovasc Med 2009;11(4):289-301.

  Rayssiguier Y, Gueux E. Magnesium and lipids in cardiovascular disease. J Am Coll Nutr 1986;5:507-519.

  Reaven GM. Syndrome X: 6 years l
ater. J Intern Med 1994;236 (suppl 736):13-22.

  ————. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995;75:473-486.

  Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM. Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest 1993;92:141-146.

  Reinhold JG. High phytate content of rural Iranian bread: a possible cause of human zinc deficiency. Am J Clin Nutr 1971;24:1204-1206.

  Remer T, Manz F. Potential renal acid load of foods and its influence on urine ph. J Am Diet Assoc 1995;95:791-797.

  Reynolds RD. Bioavailability of vitamin B6 from plant foods. Am J Clin Nutr 1988;48:863-867.

  Richards MP, Hedges RM. Gough’s cave and sun hole cave human stable isotopic values indicate a high animal protein diet in the British upper Paleolithic. J Archaeol Sci 2000;27:1-3.

  Richards MP, Pettitt PB, Trinkaus E, Smith FH, Paunovic M, Karavanic I. Neanderthal diet at Vindija and Neanderthal predation: the evidence from stable isotopes. Proc Natl Acad Sci USA 2000;97:7663-7666.

  Rifkin J. Beyond Beef. London: Thorsons, 1994.

  Robinson J. Why Grassfed Is Best. Vashon, WA: Vashon Island Press, 2000.

  Robinson SM, Jaccard C, Persaud C, Jackson AA, Jequier E, Schutz Y. Protein turnover and thermogenesis in response to high-protein and high carbohydrate feeding in men. Am J Clin Nutr 1990;52:72-80.

  Roche HM. Dietary carbohydrates and triacylglycerol metabolism. Proc Nutr Soc 1999;58:201-206.

  Rode A, Shephard RJ. Physiological consequences of acculturation: a 20 year study of fitness in an Inuit community. Eur J Appl Physiol 1994;69: 516-524.

  Roe DA. A Plague of Corn. Ithaca, NY: Cornell University Press, 1973.

  Roman SD, Clarke CL, Hall RE, Ian EA, Sutherland RL. Expression and regulation of retinoic acid receptors in human breast cancer cells. Cancer Res 1992;52:2236-2242.

  Rostow WW. The Great Population Spike and After. New York: Oxford University Press, 1998.

  Rudman D, DiFulco TJ, Galambos JT, Smith RB III, Salam AA, Warren WD. Maximal rates of excretion and synthesis of urea in normal and cirrhotic subjects. J Clin Invest 1973;52:2241-2249.