DNA USA
Page 36
Donald Gallach MacDonald, 3rd of Sleat
d. 1506
H
Ranald Mor MacDonald, 7th of Keppoch
d. 1547
I
Alan MacDonald, 4th of Clanranald
1437–1481
J
Donald Gruamach MacDonald, 4th of Sleat
d. 1534
K
Ian Moidartach MacDonald, 8th of Clanranald
1502–1584
L
Sir Donald Breac Macdonald, 10th of Sleat
1605–1678
M
Ranald Alexander MacDonald, 24th of Clanranald
Living
Clanranald
N
P. M. Macdonald
Living
Glenaladale
O
J. J. Macdonald
Living
Bornish
P
Ranald MacDonell, 23rd of Glengarry
Living
Glengarry
Q
Allan Douglas MacDonald of Vallay
Living
Vallay
R
Sir Iain Godfrey MacDonald, 25th of Sleat
Living
Sleat
S
David Foster Macdonald, 17th of
Castle Camus
Living
Castle Camus
T
D. B. Macdonald
Living
Sleat
U
W. F. Macdonald
Living
Achnancoichean
V
L. McDonald
Living
Bohuntin
Details of Y chromosome mutations in Clan Donald genealogy (See Fig.2)
LINK
MARKER
MUTATION
C–E
458
16–15
E–G
557
15–16
F–P
449
31–32
F–P
456
17–16
F–P
CDYa
34–35
G–T
GATAH4
12–11
H–U
448
20–21
H–U
449
30–31
H–U
GATAH4
12–11
H–V
570
18–19
H–V
390
25–24
I–O
CDYb
38–37
J–L
448
20–19
J–S
449
31–32
J–S
460
11–10
J–S
557
15–17
K–M
389a
14–13
K–M
390
25–24
K–M
449
31–32
K–M
576
17–18
K–M
CDYb
38–37
K–N
GATAH4
12–10
K–N
CDYa
34–33
K–N
449
31–30
K–N
458
15–16
L–R
607
16–15
Code letters in column 1 identify deceased (shaded) and living individuals on Fig. 2 (p. 108). Markers 1–38 are identified in row 2.
Numbers in table body are allele repeat lengths of Y chromosomes that differ from values deduced for Somerled (row A)
The location of 146 important genes, showing their order from right to left along each chromosome (Column 1), the body system involved (Column 2), the encoded protein (Column 3), and the international gene symbol (Column 4).
REF
SYSTEM
PROTEIN
SYMBOL
1.1
Digestion
Chymotrysin C
CTRC
1.2
Bones, skin, teeth, and joints
Bone morphogenetic protein 8a/b
BMP8A/B
1.3
Metabolism
Leptin receptor
LEPR
1.4
Digestion
Amylase
AMY1 and 2
1.5
Digestion
Cathepsin K and S
CTSK/S
1.6
Muscle
Tropomyosin 3
TPM3
1.7
Brain and nerves
Laminin gamma 2
LAMC2
1.8
Liver and kidney
Renin
REN
1.9
Muscle
Actin alpha 1, skeletal muscle
ACTA1
1.10
Eyes
Opsin 3
OPN3
2.1
Immunity
Immunoglobulin kappa constant
IGKC
2.2
Bones, skin, teeth, and joints
Bone morphogenetic protein 10
BMP10
2.3
Digestion
Lactase
LCT
2.4
Brain and nerves
Sodium channel 9
SCN9A
2.5
Heart and lung
Collagen type 3
COL1A3
2.6
Eyes
Crystallin gamma A
CRYGA
2.7
Pigmentation
Fibronectin
FN1
2.8
Eyes
Crystallin beta A2
CRYBA2
2.9
Liver and kidney
Collagen type 4,
alpha 3/4
COL4A3/4
2.10
Metabolism
Glucagon
GCG
3.1
Eyes
Retinoic acid receptor beta
RARB
3.2
Metabolism
Parathyroid hormone 1 receptor
PTH1R
3.3
Digestion
Lactotransferrin
LTF
3.4
Metabolism
Phosphodiesterase
PDE12
3.5
Muscle
Myosin HC 15
MYH15
3.6
Eyes
Rhodopsin
RHO
4.1
Brain and nerves
Huntingtin
HTT
4.2
Bones, skin, teeth, and joints
Fibroblast growth factor 3
FGFR3
4.3
Bones, skin, teeth, and joints
Enamalin
ENAM
4.4
Bones, skin, teeth, and joints
Ameloblastin
AMBN
4.5
Immunity
Immunoglobulin J
IGJ
4.6
Liver and kidney
Alcohol dehydrogenase
ADH1A
4.7
Pigmentation
Hair color 2 (red)
HCL2
5.1
Blood
Thrombospondin 4
THBS4
5.2
Muscle
Myosin X
MYOX
5.3
Pigmentation
Solute carrier, family 45, member A2
SLC45A2
5.4
Bones, skin, teeth, and joints
Growth hormone receptor
/>
GHR
5.5
Bones, skin, teeth, and joints
Fibroblast growth factor 10
FGF10
5.6
Bones, skin, teeth, and joints
Fibrillin 2
FBN2
5.7
Bones, skin, teeth, and joints
Lysyl oxidase
LOX
5.8
Bones, skin, teeth, and joints
Fibroblast growth factor 1
FGF1
5.9
Metabolism
Insulin dependent diabetes 10
IDDM10
6.1
Immunity
HLA region
HGC
6.2
Eyes
Opsin 5
OPN5
6.3
Muscle
Myosin VI
MYO6
6.4
Brain and nerves
Laminin alpha 2/4
LAMA2/4
6.5
Brain and nerves
Opioid receptor mu 1
OPRM1
6.6
Blood
Plasminogen
PLG
6.7
Blood
Thrombospondin 2
THBS2
7.1
Muscle
Actin beta
ACTB
7.2
Muscle
Myosin light chain 7
MYL7
7.3
Bones, skin, teeth, and joints
Elastin
ELN
7.4
Blood
Erythropoietin
EPO
7.5
Bones, skin, teeth, and joints
Collagen type 1, alpha 2
COL1A2
7.6
Brain and nerves
Acetylcholinesterase
ACHE
7.7
Eyes
Opsin 1 cone short wave
OPN1SW
7.8
Brain and nerves
Olfactory receptor 2A.25
OR2A25
8.1
Heart and lung
Surfactant protein C
SFTPC
8.2
Bones, skin, teeth, and joints
Fibroblast growth factor receptor 1
FGFR1
8.3
Blood
Plasminogen activator (tissue)
HBB
8.4
Brain and nerves
Opioid receptor kappa 1
OPRK1
8.5
Blood
Angiopoietin 1
ANGPT1
8.6
Brain and nerves
Otoconin
OC90
9.1
Immunity
Inteferon alpha
IFNA
9.2
Muscle
Tropomyosin 2
TPM2
9.3
Digestion
Beta glucosidase (bile acid)
GBA2
9.4
Bones, skin, teeth, and joints
Osteoclast stimulating factor 1
OSTF1
9.5
Bones, skin, teeth, and joints
Osteoglycin
OGN
9.6
Blood
Hemogen
HEMGN
9.7
Blood
ABO blood group
ABO
10.1
Eyes
Optineurin
OPTN
10.2
Muscle
Myosin IIIA
MYO3A
10.3
Eyes
Opsin 4
OPN4
10.4
Muscle
Actin alpha 2, smooth muscle
ACTA2
10.5
Digestion
Trypsin
TYSND1
10.6
Heart and lung
Adrenergic alpha 2A/beta receptor
ADRA2A/B1
10.7
Metabolism
Cytochrome P450, family 2C, polypeptide
CYP2C9
10.8
Heart and lung
Pancreatic lipase
PNLIP
11.1
Blood
Beta globin
HBB
11.2
Metabolism
Insulin
INS
11.3
Brain and nerves
Otogelin
OTOG
11.4
Digestion
Pepsin
PGA3
11.5
Digestion
Cathepsin C
CTSC
11.6
Pigmentation
Tyrosinase
TYR
11.7
Eyes
Crystallin alpha B
CRYAB
11.8
Immunity
Thymocyte cell surface antigen
THY1
12.1
Immunity
Alpha 2 macroglobulin
A2M
12.2
Digestion
Islet amyloid polypeptide
IAPP
12.3
Pigmentation
Keratin 1-5
KRT1-5
12.4
Bones, skin, teeth, and joints
Collagen type 2
COL2A1
12.5
Digestion
Peptidase B
PEPB
12.6
Pigmentation
KIT ligand
KITLG
12.7
Immunity
Thympoietin
TMPO
12.8
Digestion
Phopholipase A2
PLA2G1B
13.1
Brain and nerves
Olfactomedin 4
OLFM4
13.2
Brain and nerves
Olfactory receptor E
OR7E
13.3
Muscle
Myosin XVI
MYO16
13.4
Liver and kidney
Collagen type 4, alpha 1 and 2
COL4A1/2
14.1
Heart and lung
Myosin heavy chain 6 and 7, cardiac
MYH6/7
14.2
Metabolism
Estrogen receptor 2
ESR2
14.3
Bones, skin, teeth, and joints
Bone morphogenetic protein 4
BMP4
14.4
Blood
Spectrin beta
SPTB
14.5
Digestion
Chymotrypsin
CTRB1
14.6
Brain and nerves
Creatine kinase (brain)
CKB
14.7
Immunity
Immunoglobulin H alpha 1
IGHA1 et al.
15.1
Muscle
Actin alpha 1, cardiac muscle
ACTC1
15.2
Pigmentation
Oculocutaneous albinism II
OCA2
15.3
Brain and nerves
Cholinergic receptor nicotinic alpha 7
CHRNA7
15.4
Pigmentation
Solute carrier, family 24 member 5
SLC24A5
15.5
Blood
Thrombospondin 1
THBS1
15.6
Muscle
Myosin 1E
MYO1E
15.7
Pigmentation
Hair color 3 (brown)
HCL3
15.8
Bones, skin, teeth, an
d joints
Chondroitin sulfate proteoglycan 4
CSPG4
15.9
Bones, skin, teeth, and joints
Aggrecan
ACAN
16.1
Blood
Alpha globin
HBA1 and 2
16.2
Digestion
Myosin HC 11, smooth muscle
MYH11
16.3
Blood
Alpha hemoglobin stabilizing protein
AHSP
16.4
Muscle
Myosin light chain kinase 3
MYLK3
16.5
Blood
Haptoglobin
HP
16.6
Digestion
Chymotrypsinogen B1/2
CTRB1/2
16.7
Pigmentation
Melanocortin 2 receptor
MC2R
17.1
Muscle
Myosin, heavy chain 1, skeletal adult
MYH1-4
17.2
Eyes
Crystallin beta A1
CRYBA1
17.3
Bones, skin, teeth, and joints
Collagen type 1, alpha 1
COL1A1
17.4
Digestion
Gastrin
GAST
17.5
Heart and lung
Angiotensin 1 converting enzyme
ACE
17.6
Metabolism
Glucagon receptor
GCGR
17.7