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Vitamin C- The Real Story

Page 22

by Steve Hickey


  15. Cathcart, R.F. Unpublished paper on AIDS. (Letter to Editor.) Critical Path Project, 1992.

  16. Kalokerinos, A. Every Second Child. Melbourne, Australia: Thomas Nelson, 1974.

  Chapter 7: Cancer and Vitamin C

  1. Nakagaki, T., H. Yamada, A. Tóth. “Intelligence: Maze-solving by an Amoeboid Organism.” Nature 407 (2000): 470.

  2. Shaffer, B.M. “Secretion of Cyclic AMP Induced by Cyclic AMP in the Cellular Slime Mould Dictyostelium discoideum.” Nature 255 (1975): 549–552.

  3. Hardman, A.M., G.S. Stewart, P. Williams. “Quorum Sensing and the Cell-Cell Communication Dependent Regulation of Gene Expression in Pathogenic and Non-pathogenic Bacteria.” Antonie Van Leeuwenhoek J Microbiol Serol 74 (1998): 199–210. Fuqua, C., and E.P. Greenberg. “Self Perception in Bacteria: Quorum Sensing with Acylated Homoserine Lactones.” Curr Opin Microbiol 1 (1998): 183–189.

  4. Lewis, K. “Programmed Death in Bacteria.” Microbiol Molec Biol Rev 64:3 (2000): 503–514.

  5. Everson, T.C., and W.H. Cole. Spontaneous Regression of Cancer. Philadelphia, PA: W.B. Saunders, 1966. Boyd, W. Spontaneous Regression of Cancer. Springfield, IL: Charles C. Thomas, 1966.

  6. Voght, A. “On the Vitamin C Treatment of Chronic Leukemias.” Deutsche Med Wochenschr 14 (April 1940): 369–372.

  7. McCormick, W.J. “Cancer: The Preconditioning Factor in Pathogenesis.” Arch Pediatr 71 (1954): 313–322. McCormick, W.J. “Cancer: A Collagen Disease, Secondary to a Nutritional Deficiency?” Arch Pediatr 76 (1959): 166–171.

  8. Stone, I. The Healing Factor: “Vitamin C” Against Disease. New York, NY: Grosset and Dunlap, 1972.

  9. Greer, E. “Alcoholic Cirrhosis: Complicated by Polycythemia Vera and Then Myelogenous Leukemia and Tolerance of Large Doses of Vitamin C.” Medical Times 82 (1954): 765–768.

  10. Cameron, E., and D. Rotman. “Ascorbic Acid, Cell Proliferation, and Cancer.” Lancet 1 (1972): 542. Cameron, E., and L. Pauling. “Ascorbic Acid and the Glycosaminoglycans: An Orthomolecular Approach to Cancer and Other Diseases.” Oncology 27 (1973): 181–192. Cameron, E., and A. Campbell. “The Orthomolecular Treatment of Cancer II. Clinical Trial of High-dose Ascorbic Acid Supplements in Advanced Human Cancer.” Chem Biol Interact 9 (1974): 285–315. Cameron, E., and L. Pauling. “Supplemental Ascorbate in the Supportive Treatment of Cancer: Prolongation of Survival Times in Terminal Human Cancer.” Proc Natl Acad Sci USA 73 (1976): 3685–3689. Cameron, E., and L. Pauling. “Supplemental Ascorbate in the Supportive Treatment of Cancer: Reevaluation of Prolongation of Survival Times in Terminal Human Cancer.” Proc Natl Acad Sci USA 75 (1978): 4538–4542. Cameron, E. “Vitamin C for Cancer.” N Engl J Med 302 (1980): 299. Cameron, E., and A. Campbell. “Innovation vs. Quality Control: An ‘Unpublishable’ Clinical Trial of Supplemental Ascorbate in Incurable Cancer.” Med Hypotheses 36 (1991): 185–189.

  11. Campbell, A., T. Jack, E. Cameron. “Reticulum Cell Sarcoma: Two Complete ‘Spontaneous’ Regressions in Response to High-dose Ascorbic Acid Therapy. A Report on Subsequent Progress.” Oncology 48 (1991): 495–497.

  12. Pauling, L. Personal communication.

  13. Hickey, S., and H. Roberts. “Selfish Cells: Cancer as Microevolution.” J Orthomolecular Med (2007) (in press).

  14. Hickey, S., and H. Roberts. Cancer: Nutrition and Survival. Lulu Press, 2005.

  15. Schafer, F.Q., and G.R. Buettner. “Redox Environment of the Cell as Viewed through the Redox State of the Glutathione Disulfide/Glutathione Couple.” Free Radic Biol Med 30:11 (2001): 1191–1212.

  16. Matheu, A., A. Maraver, P. Klatt, et al. “Delayed Ageing through Damage Protection by the Arf/p53 Pathway.” Nature 448:7151 (2007): 375–381.

  17. Hickey, S., and H. Roberts. Ascorbate: The Science of Vitamin C. Lulu Press, 2004.

  18. Gunn, H. “The Use of Antioxidants with Chemotherapy and Radiotherapy in Cancer Treatment: A Review.” J Orthomolecular Med 19:4 (2004): 246. Stoute, J.A. “The Use of Vitamin C with Chemotherapy in Cancer Treatment: An Annotated Bibliography.” J Orthomolecular Med 19:4 (2004): 198. Hoffer, A. “The Use of Vitamin C and Other Antioxidants with Chemotherapy and Radiotherapy in Cancer Treatment.” J Orthomolecular Med 19:4 (2004): 195.

  19. Hickey, S., and H. Roberts. The Cancer Breakthrough. Lulu Press, 2007.

  Chapter 8: Heart Disease

  1. Hoffer, A., and M. Walker. Putting It All Together: The New Orthomolecular Nutrition. New Canaan, CT: Keats, 1978.

  2. Yavorsky, M., P. Almaden, C.G. King. “The Vitamin C Content of Human Tissues.” J Biol Chem 106:2 (1934): 525–529.

  3. Lewin, S. Vitamin C: Its Molecular Biology and Medicinal Potential. New York, NY: Academic Press, 1976.

  4. McCormick, W.J. “Coronary Thrombosis: A New Concept of Mechanism and Etiology.” Clin Med 4:7 (July 1957). Paterson, J.C. “Some Factors in the Causation of Intimal Hemorrhages and in the Precipitation of Coronary Thrombi.” Can Med Assoc J (February 1941): 114–120. Paterson, J.C. “Capillary Rupture with Intimal Haemorrhage in the Causation of Cerebral Vascular Lesions.” Arch Pathol 29 (1940): 345–354. Willis, G.C. “An Experimental Study of the Intimal Ground Substance in Atherosclerosis.” Can Med Assoc J 69 (1953): 17–22. Willis, G.C. “The Reversibility of Atherosclerosis.” Can Med Assoc J 77 (1957): 106–109. Willis, G.C., A.W. Light, W.S. Cow. “Serial Arteriography in Atherosclerosis.” Can Med Assoc J 71 (1954): 562–568. Willis, G.C., and S. Fishman. “Ascorbic Acid Content of Human Arterial Tissue.” Can Med Assoc J 72 (April 1955): 500–503.

  5. Rath, M., and L. Pauling. “Immunological Evidence for the Accumulation of Lipoprotein(a) in the Atherosclerotic Lesion of the Hypoascorbemic Guinea Pig.” Proc Natl Acad Sci 87:23 (December 1990): 9388–9390. Rath, M., and L. Pauling. “Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause is Ascorbate Deficiency, Leading to the Deposition of Lipoprotein(a) and Fibrinogen/Fibrin in the Vascular Wall.” J Orthomolecular Med 6 (1991): 125–134. Pauling, L., and M. Rath. “Prevention and Treatment of Occlusive Cardiovascular Disease with Ascorbate and Substances that Inhibit the Binding of Lipoprotein(A).” U.S. Patent 5,278,189 (1994). Pauling, L., and M. Rath. “Use of Ascorbate and Tranexamic Acid Solution for Organ and Blood Vessel Treatment Prior to Transplantation.” U.S. Patent 5,230,996 (1993). Rath, M., and A. Niedzwiecki. “Nutritional Supplement Program Halts Progression of Early Coronary Atherosclerosis Documented by Ultrafast Computed Tomography.” J Appl Nutr 48 (1996): 68–78.

  6. Hickey, S., and H. Roberts. Ascorbate: The Science of Vitamin C. Lulu Press, 2004.

  7. Harjai, K.J. “Potential New Cardiovascular Risk Factors: Left Ventricular Hypertrophy, Homocysteine, Lipoprotein(a), Triglycerides, Oxidative Stress, and Fibrinogen.” Ann Intern Med 131 (1999): 376–386. Grant, P.J. “The Genetics of Atherothrombotic Disorders: A Clinician’s View.” J Thromb Haemost 1 (2003): 1381–1390. Maas, R., and R.H. Boger. “Old and New Cardiovascular Risk Factors: From Unresolved Issues to New Opportunities.” Atheroscler Suppl 4 (2003): 5–17. Dominiczak, M.H. “Risk Factors for Coronary Disease: The Time for a Paradigm Shift?” Clin Chem Lab Med 39 (2001): 907–919. Frostegard, J. “Autoimmunity, Oxidized LDL and Cardiovascular Disease.” Autoimmun Rev 1 (2002): 233–237.

  8. Harrison, D.G., H. Cai, U. Landmesser, et al. “Interactions of Angiotensin II with NAD(P)H Oxidase, Oxidant Stress and Cardiovascular Disease.” J Renin Angiotensin Aldosterone Syst 4 (2003): 51–61. Cuff, C.A., D. Kothapalli, E. Azonobi, et al. “The Adhesion Receptor CD44 Promotes Atherosclerosis by Mediating Inflammatory Cell Recruitment and Vascular Cell Activation.” J Clin Invest 108 (2001): 1031–1040. Huang, Y., L. Song, S. Wu, et al. “Oxidized LDL Differentially Regulates MMP-1 and TIMP-1 Expression in Vascular Endothelial Cells.” Atherosclerosis 156 (2001): 119–125. McIntyre, T.M., S.M. Prescott, A.S. Weyrich, et al. “Cell-Cell Interactions: Leukocyte-Endothelial Interactions.” Curr Opin Hematol 10 (2003): 150–158.

  9. Gonzalez, M.A., and A.P. Selwyn. “Endothelial Function, Inflammation, and Prognosis in Cardiovascular Dise
ase.” Am J Med 115 (2003): 99S–106S.

  10. Weber, C., E. Wolfgang, K. Weber, et al. “Increased Adhesiveness of Isolated Monocytes to Epithelium is Prevented by Vitamin C Intake in Smokers.” Circulation 93 (1996): 1488–1492.

  11. Scribner, A.W., J. Loscalzo, C. Napoli. “The Effect of Angiotensin-converting Enzyme Inhibition on Endothelial Function and Oxidant Stress.” Eur J Pharmacol 482 (2003): 95–99. Elisaf, M. “Effects of Fibrates on Serum Metabolic Parameters.” Curr Med Res Opin 18 (2002): 269–276. Vane, J.R., and R.M. Botting. “The Mechanism of Action of Aspirin.” Thromb Res 110 (2003): 255–258. Carneado, J., M. Alvarez de Sotomayor, C. Perez-Guerrero, et al. “Simvastatin Improves Endothelial Function in Spontaneously Hypertensive Rats through a Superoxide Dismutase Mediated Antioxidant Effect.” J Hyper tens 20 (2002): 429–437. Erkkila, L., M. Jauhiainen, K. Laitinen, et al. “Effect of Simvastatin, an Established Lipid-lowering Drug, on Pulmonary Chlamydia pneumoniae Infection in Mice.” Antimicrob Agents Chemother 49:9 (2005): 3959–3962.

  12. Stone, I. The Healing Factor: Vitamin C Against Disease. New York, NY: Putnam, 1974. Hickey, S., and H. Roberts. Ascorbate: The Science of Vitamin C. Lulu Press, 2004. Levy, T.E. Stop America’s #1 Killer. LivOn Books, 2006.

  13. Salzar, R.S., M.J. Thubrikar, R.T. Eppink. “Pressure-induced Mechanical Stress in the Carotid Artery Bifurcation: A Possible Correlation to Atherosclerosis.” J Biomech 28:11 (1995): 1333–1340.

  14. D’Orleans-Juste, P., J. Labonte, G. Bkaily, et al. “Function of the Endothelin(B) Receptor in Cardiovascular Physiology and Pathophysiology.” Pharmacol Ther 95 (2002): 221–238. Annuk, M., M. Zilmer, B. Fellstrom. “Endothelium-dependent Vasodilation and Oxidative Stress in Chronic Renal Failure: Impact on Cardiovascular Disease.” Kidney Intl Suppl 84 (2003): S50-S53. Egashira, K. “Clinical Importance of Endothelial Function in Arteriosclerosis and Ischemic Heart Disease.” Circ J 66 (2002): 529–533. Luscher, T.F., F.C. Tanner, M.R. Tschudi, et al. “Endothelial Dysfunction in Coronary Artery Disease.” Annu Rev Med 44 (1993): 395–418.

  15. Gong, L., G.M. Pitari, S. Schulz, et al. “Nitric Oxide Signaling: Systems Integration of Oxygen Balance in Defense of Cell Integrity.” Curr Opin Hematol 11 (2004): 7–14. Sumpio, B.E., J.T. Riley, A. Dardik. “Cells in Focus: Endothelial Cell.” Intl J Biochem Cell Biol 34 (2002): 1508–1512. Ando, J., and A. Kamiya. “Blood Flow and Vascular Endothelial Cell Function.” Front Med Biol Eng 5 (1993): 245–264.

  16. Higgins, J.P. “Can Angiotensin-converting Enzyme Inhibitors Reverse Atherosclerosis?” South Med J 96 (2003): 569–579. Harrison, D.G., and H. Cai. “Endothelial Control of Vasomotion and Nitric Oxide Production.” Cardiol Clin 21 (2003): 289–302. Stankevicius, E., E. Kevelaitis, E. Vainorius, et al. “Role of Nitric Oxide and Other Endothelium-derived Factors.” Medicina (Kaunas) 39 (2003): 333–341. Vane, J.R., and R.M. Botting. “Secretory Functions of the Vascular Endothelium.” J Physiol Pharmacol 43 (1992): 195–207. Chauhan, S.D., H. Nilsson, A. Ahluwalia, et al. “Release of C-type Natriuretic Peptide Accounts for the Biological Activity of Endothelium-derived Hyper-polarizing Factor.” Proc Natl Acad Sci USA 100 (2003): 1426–1431.

  17. Pearson, J.D. “Endothelial Cell Function and Thrombosis.” Baillieres Best Pract Res Clin Haematol 12 (1999): 329–341. Huber, D., E.M. Cramer, J.E. Kaufmann, et al. “Tissue-type Plasminogen Activator (t-PA) is Stored in Weibel-Palade Bodies in Human Endothelial Cells Both in Vitro and in Vivo.” Blood 99 (2002): 3637–3645.

  18. Vallance, P., J. Collier, S. Moncada. “Effects of Endothelium-derived Nitric Oxide on Peripheral Arteriolar Tone in Man.” Lancet 2 (1989): 997–1000.

  19. Major, T.C., R.W. Overhiser, R.L. Panek. “Evidence for NO Involvement in Regulating Vascular Reactivity in Balloon-injured Rat Carotid Artery.” Am J Physiol 269 (1995): H988–H996.

  20. Taddei, S., A. Virdis, L. Ghiadoni, et al. “Vitamin C Improves Endothelium-dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension.” Circulation 97:22 (1998): 2222–2229.

  21. Hampl, V. “Nitric Oxide and Regulation of Pulmonary Vessels.” Cesk Fysiol 49 (2000): 22–29.

  22. Stankevicius, E., E. Kevelaitis, E. Vainorius, et al. “Role of Nitric Oxide and Other Endothelium-derived Factors.” Medicina (Kaunas) 39 (2003): 333–341.

  23. De Nigris, F., L.O. Lerman, W.S. Ignarro, et al. “Beneficial Effects of Antioxidants and L-Arginine on Oxidation-sensitive Gene Expression and Endothelial NO Synthase Activity at Sites of Disturbed Shear Stress.” Proc Natl Acad Sci USA 100:3 (February 2003): 1420–1425.

  24. Shmit, E. “Antioxidant Vitamins May Prevent Blood Vessel Blockage and Protect Against Cardiovascular Disease.” UCLA News (January 15, 2003).

  25. Watanabe, T., R. Pakala, T. Katagiri, et al. “Monocyte Chemotactic Protein 1 Amplifies Serotonin-induced Vascular Smooth Muscle Cell Proliferation.” J Vasc Res 38 (2001): 341–349. Rainger, G.E., and G.B. Nash. “Cellular Pathology of Atherosclerosis: Smooth Muscle Cells Prime Cocultured Endothelial Cells for Enhanced Leukocyte Adhesion.” Circ Res 88 (2001): 615–622. Desai, A., H.A. Lankford, J.S. Warren. “Homocysteine Augments Cytokine-induced Chemokine Expression in Human Vascular Smooth Muscle Cells: Implications for Atherogenesis.” Inflammation 25 (2001): 179–186.

  26. Libby, P. “Changing Concepts of Atherogenesis.” J Intern Med 247 (2000): 349–358.

  27. Kockx, M.M., and A.G. Herman. “Apoptosis in Atherosclerosis: Beneficial or Detrimental?” Cardiovasc Res 45 (2000): 736–746. Gronholdt, M.L., S. Dalager-Pedersen, E. Falk. “Coronary Atherosclerosis: Determinants of Plaque Rupture.” Eur Heart J 19 (1998): C24–C29.

  28. Bennett, M.R. “Breaking the Plaque: Evidence for Plaque Rupture in Animal Models of Atherosclerosis.” Arterioscler Thromb Vasc Biol 22 (2002): 713–714. Bennett, M.R. “Vascular Smooth Muscle Cell Apoptosis—A Dangerous Phenomenon in Vascular Disease.” J Clin Basic Cardiol 3 (2000): 63–65.

  29. Kolodgie, F.D., H.K. Gold, A.P. Burke, et al. “Intraplaque Hemorrhage and Progression of Coronary Atheroma.” N Engl J Med 349 (2003): 2316–2325. Fan, J., and T. Watanabe. “Inflammatory Reactions in the Pathogenesis of Atherosclerosis.” J Atheroscler Thromb 10 (2003): 63–71.

  30. Barbieri, S.S., S. Eligini, M. Brambilla, et al. “Reactive Oxygen Species Mediate Cyclooxygenase-2 Induction during Monocyte to Macrophage Differentiation: Critical Role of NADPH Oxidase.” Cardiovasc Res 60 (2003): 187–197.

  31. Carpenter, K.L., I.R. Challis, M.J. Arends. “Mildly Oxidised LDL Induces More Macrophage Death than Moderately Oxidised LDL: Roles of Peroxidation, Lipoprotein-associated Phospholipase A2 and PPARgamma.” FEBS Lett 553 (2003): 145–150. Norata, G.D., L. Tonti, P. Roma, et al. “Apoptosis and Proliferation of Endothelial Cells in Early Atherosclerotic Lesions: Possible Role of Oxidised LDL.” Nutr Metab Cardiovasc Dis 12 (2002): 297–305.

  32. Berliner, J.A., and J.W. Heinecke. “The Role of Oxidized Lipoproteins in Atherogenesis.” Free Radical Biol Med 20 (1996): 707–727.

  33. Libby, P., and M. Aikawa. “Effects of Statins in Reducing Thrombotic Risk and Modulating Plaque Vulnerability.” Clin Cardiol 26 (2003): I11-I14. Libby, P., and M. Aikawa. “Stabilization of Atherosclerotic Plaques: New Mechanisms and Clinical Targets.” Nat Med 8 (2002): 1257–1262.

  34. Sutter, M.C. “Lessons for Atherosclerosis Research from Tuberculosis and Peptic Ulcer.” Can Med Assoc J 152:5 (1995): 667–670. Capron, L. “Viruses and Atherosclerosis.” Rev Prat 40:24 (1990): 2227–2233. Benitez, R.M. “Atherosclerosis: An Infectious Disease?” Hosp Pract (Minneapolis) 34:9 (1999): 79–82, 85–86, 89–90. Streblow, D.N., S.L. Orloff, J.A. Nelson. “Do Pathogens Accelerate Atherosclerosis?” J Nutr 131:10 (2001): 2798S-2804S.

  35. Mehta, J.L., T.G. Saldeen, K. Rand. “Interactive Role of Infection, Inflammation and Traditional Risk Factors in Atherosclerosis and Coronary Artery Disease.” J Am Coll Cardiol 31:6 (1998): 1217–1225. Broxmeyer, L. “Heart Disease: The Greatest ‘Risk’ Factor of Them All.” Med Hypotheses 62:5 (2004): 773–779.

  36. Friedman, H.M.
, E.J. Macarak, R.R. MacGregor, et al. “Virus Infection of Endothelial Cells.” J Infect Dis 143:2 (1981): 266–273. Tumilowicz, J.J., M.E. Gawlik, B.B. Powell, et al. “Replication of Cytomegalovirus in Human Arterial Smooth Muscle Cells.” J Virol 56:3 (1985): 839–845. Morre, S.A., W. Stooker, W.K. Lagrand, et al. “Microorganisms in the Aetiology of Atherosclerosis.” J Clin Pathol 53:9 (2000): 647–654.

  37. Ooboshi, H., C.D. Rios, Y. Chu, et al. “Augmented Adenovirus-mediated Gene Transfer to Atherosclerotic Vessels.” Arterioscler Thromb Vasc Biol 17:9 (1997): 1786–1792.

  38. Ellis, R.W. “Infection and Coronary Heart Disease.” J Med Microbiol 46:7 (1997): 535–539. Mattila, K.J., V.V. Valtonen, M.S. Nieminen, et al. “Role of Infection as a Risk Factor for Atherosclerosis, Myocardial Infarction, and Stroke.” Clin Infect Dis 26:3 (1998): 719–734.

  39. Chiu, B. “Multiple Infections in Carotid Atherosclerotic Plaques.” Am Heart J 138:5 Part 2 (1999): S534-S536. Vercellotti, G.M. “Overview of Infections and Cardiovascular Diseases.” J Allergy Clin Immunol 108:4 Suppl (2001): S117-S120.

  40. Wanishsawad, C., Y.F. Zhou, S.E. Epstein. “Chlamydia pneumoniae-induced Transactivation of the Major Immediate Early Promoter of Cytomegalovirus: Potential Synergy of Infectious Agents in the Pathogenesis of Atherosclerosis.” J Infect Dis 181:2 (2000): 787–790. Burnett, M.S., C.A. Gaydos, G.E. Madico, et al. “Atherosclerosis in ApoE Knockout Mice Infected with Multiple Pathogens.” J Infect Dis 183:2 (2001): 226–231. Watt, S., B. Aesch, P. Lanotte, et al. “Viral and Bacterial DNA in Carotid Atherosclerotic Lesions.” Eur J Clin Microbiol Infect Dis 22:2 (2003): 99–105. Virok, D., Z. Kis, L. Kari, et al. “Chlamydophila pneumoniae and Human Cytomegalovirus in Atherosclerotic Carotid Plaques—Combined Presence and Possible Interactions.” Acta Microbiol Immunol Hungary 53:1 (2006): 35–50.

  41. Espinola-Klein, C., H.J. Rupprecht, S. Blankenberg, et al. “Impact of Infectious Burden on Extent and Long-term Prognosis of Atherosclerosis.” Circulation 105:1 (2002): 15–21. Espinola-Klein, C., H.J. Rupprecht, S. Blankenberg, et al. “Impact of Infectious Burden on Progression of Carotid Atherosclerosis.” Stroke 33:11 (2002): 2581–2586. Auer, J., M. Leitinger, R. Berent, et al. “Influenza A and B IgG Seropositivity and Coronary Atherosclerosis Assessed by Angiography.” Heart Dis 4:6 (2002): 349–354.

 

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