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This novel interweaves Renaissance artist Piero di Cosimo's fifteenth-century viewpoint with the twenty-first-century reality of two young Canadian students: Agnes Vane, an art history major fascinated by di Cosimo's multi-layered imagery, and Peter (Pinto) Dervaig, a student of philosophy passionate about preventing cruelty to animals. Both Agnes and Pinto were marginalized in their adolescence because of their unusual appearance. Agnes has slightly simian features. Pinto is a huge man with a multihued skin pigmentation. When Agnes, as a lonely and alienated child, discovers di Cosimo's empathetic paintings of animals and human-animal hybrids, she feels she is looked upon gently for the first time in her life. That moment influences her decision to become an animal rights activist, a commitment that ultimately brings her both anguish and insight. Her story is echoed by chapters from di Cosimo's perspective as he pits his solitary vision, of a golden age when animals did indeed...