The Cancer Chronicles
Page 34
Dmrt5 molecule
DNA, 5.1, 5.2, 7.1, 8.1, 12.1, 13.1, epl.1
duplication errors in, 1.1, 1.2, 2.1, 2.2, 2.3, 3.1, 13.1
in embryonic development
in genetics
mitochondrial
radiation and, 1.1, 5.1, 11.1, 13.1
repair of, 1.1, 5.1, 8.1, 11.1, 12.1, 13.1
in viruses
Doll, Richard, 7.1, 7.2, 7.3, 10.1, 10.2
double helix, 5.1, 5.2, 8.1, 9.1
doxorubicin (Adriamycin), 8.1, 8.2, 8.3
drugs
in cancer treatment, 9.1, 10.1, 13.1
money matters and
naming of
prediction of efficacy of
testing of
see also chemotherapy; pharmaceutical companies; specific medications
dwarfism
Echthroi, 13.1, 13.2, epl.1
Edison, Thomas
Edmontosaurus, 1.1, 2.1
Egypt, ancient, 3.1, 3.2
Ehrenreich, Barbara
Eighth Day of Creation, The: Makers of the Revolution in Biology (Judson)
Eldredge, Niles
electrical power lines, 2.1, 13.1
electricity, and mitosis
electromagnetism, 8.1, 13.1, 13.2
electron microscopes, 3.1, 3.2
elephantiasis
embryos
development of, 5.1, 6.1, 7.1
tumors compared to, 6.1, 9.1
Emperor of All Maladies, The (Mukherjee)
endometrial cancer, 2.1, 13.1
endometrial curettage
endometrioid adenocarcinoma
endometrium, 2.1, 6.1
endothelial cells
entosis
entropy
Echthroi as agents of
inevitable triumph of, 13.1, epl.1
as source of cancer, 1.1, 7.1, 10.1, 13.1
environment
cancer sources in, 7.1, 7.2
misinterpretation of term
environmental movement
Environmental Protection Agency, 2.1, 7.1
in radon testing, 11.1, 11.2
epidemiology, 10.1, 10.2, 10.3, 11.1
of cancer
shortcomings of self-reporting in, 2.1, 10.1
epigenetic theory, 9.1, 9.2, 11.1
epigenome, 9.1, 9.2
epithelial-mesenchymal transition (EMT)
Epstein, Samuel
Erbitux
Erin Brockovich,
Erivedge (vismodegib)
Ernst, Max
Escherichia coli,
esophageal cancer, 1.1, 2.1, 10.1
Esquire,
estrogen, 2.1, 10.1
as carcinogen, 2.1, 7.1, 10.1, 11.1
European Prospective Investigation into Cancer and Nutrition (EPIC), 10.1, 10.2, 13.1
evolutionary biology, 12.1, 13.1
“Evolutionary Dynamics of Cancer” (Michor), 12.1
Ewing’s sarcoma
exercise, in cancer prevention, 2.1, 7.1, 10.1, 10.2, 10.3
eyes
cancer of
cyclopean, 1.1, 6.1, 12.1
Fantastic Voyage,
Farley, Emma
farolitos,
fat, in metabolism
Federal Communications Commission
Ferrante I of Aragon
fes gene
fetus
fiber, dubious benefits of
fibroblasts
fibroids
fibrous dysplasia
Fidler, Isaiah
field cancerization
Field Museum, 1.1, 1.2
fish
cancer in, 1.1, 1.2, 1.3
consumption of
5 A Day program, 2.1, 10.1
Fleming, Alexander, 9.1, 10.1
fluoride
folates, folic acid
Folkman, Judah
Food, Nutrition and the Prevention of Cancer: A Global Perspective,
follow-up report (Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective)
Food and Drug Administration (FDA), 6.1, 8.1, 9.1, 12.1, 12.2, 12.3
forest fires
fossils
cancer observed in, 1.1, 3.1, 3.2, 3.3
fuel from
fragile X
free radicals, 2.1, 13.1
fringe genes
fruit flies, genetic research with, 5.1, 6.1
Galen of Pergamon, 3.1, 4.1
Galis, Frietson
game theory
gamma rays, 2.1, 2.2, 2.3, 11.1, 11.2, 13.1
gardens, author’s, 4.1, 13.1
Genentech, 9.1, 12.1, 12.2
genes
cancer-causing
growth-restraining
see also specific genes
genetic damage, 1.1, 3.1, 3.2
genetic messaging
genetic mutation, 5.1, 6.1
genetics
in cancer risk, 1.1, 2.1, 2.2, 3.1, 7.1, 7.2, 10.1, 10.2, 12.1, 13.1
in embryo development
environmental factors vs.
population
statistical research in
terminology of
genomes, 2.1, 5.1, 6.1, 9.1, 9.2, 11.1, 11.2, 12.1, 13.1, 13.2, epl.1
geography, and cancer risk
Germany, 3.1, 3.2, 4.1
germ cells
Gitau, Juma
Gleevec
gliomas
glucose, 2.1, 9.1, 10.1, 10.2, 13.1, 13.2
glycogen
Gorlin syndrome
Gould, Stephen Jay, 8.1, 12.1
gout
Grady, Denise, 8.1
“Great Cancer Wars,”
Green River, 1.1, 1.2
Grufferman, Seymour
Gunther, John
Gynecologic Oncology,
Haddow, Alexander
Hadrosauridae
“Hallmarks of Cancer, The” (Hanahan and Weinberg)
“Hallmarks of Cancer: The Next Generation” (Hanahan and Weinberg)
Hamann-Todd Human Osteological Collection
hamsters
Hanahan, Douglas, 9.1, 9.2
Harmon, Amy
Hart, Ian
Harvard, 8.1, 9.1, 9.2, 10.1, 12.1, 12.2
Hayflick limit
heart
cancer of
“cell fate” and
chemotherapy damage to
heart disease, 10.1, 10.2, 10.3
hedgehog genes, 6.1, 12.1
height
Helicobacter pylori, 7.1, 9.1
hemangiomas, 1.1, 1.2
hepatitis, 2.1, 3.1, 5.1, 7.1, 7.2, 9.1
HER2/neu, gene, 8.1, 9.1, 12.1
“HER2/neu Overexpression: Has the Achilles’ Heel of Uterine Serous Papillary Carcinoma Been Exposed?,”
herbicides
Herceptin (trastuzumab), 8.1, 9.1, 12.1
Hershey, Alfred
Hillis, Daniel
Hippocrates, 3.1, 4.1
Hippocratic oath
Hippo genes
Hiroshima
Hispanics
histidine
“hitchhiker” mutations
HIV/AIDS
Hodgkin’s lymphoma, 7.1, 7.2, 8.1
Holocene era
holoprosencephaly
Hooker Electrochemical Company
hope, hopefulness
for cancer cure, 9.1, 9.2, 9.3
as coping mechanism, 2.1, 3.1, 8.1, 8.2, 11.1, 12.1, epl.1, epl.2
in Nancy’s cancer, 6.1, 8.1
hormesis
hormone replacement therapies, 2.1, 7.1
hormones
as destructive
endocrine system
see also specific hormones
horses, Nancy’s love of, 13.1, 13.2
Human Microbiome Project
human papillomavirus (HPV), 3.1, 5.1, 7.1, 7.2, 10.1, epl.1
hummingbirds
humors
Huntington’s disease
hyperotosis
hypertumors
hysterectomy, 4.1, 6.1
“immortal devil,”
immune system, 3.1, 4.1, 5.1, 9.1, 10.1, 11.1, 12.1, 13.1
boosters, 9.1, 13.1
compromised
lymph in
immunoglobulins
Imperial College School of Medicine
impotence
incontinence, 12.1
India
industrial chemicals, as cancer source, 1.1, 2.1, 7.1, 7.2, 7.3, 7.4, 7.5, 10.1
Industrial Revolution
inflammation, cancer risk from, 9.1, 10.1
insects, tumors in
insulin, in cancer risk, 2.1, 10.1, 10.2
insulin-like growth factors (IGFs)
International Agency for Research on Cancer, 7.1, 13.1
Internet
in cancer research
misinformation on
wireless
Interphone
introns
ionizing radiation, 1.1, 11.1, 13.1, 13.2
Iowa, radon levels in
Iron Age
Italy, 10.1, 10.2
Japan, 7.1, 7.2, 10.1
Java man
jaw
Joe’s cancer of
Kanam
of primitive fish
Jesse H. Jones Rotary House International
Joe see Johnson, Joe
Johnson, Joe (author’s brother)
cancer of
healthy lifestyle of
treatment strategy for
Joliot-Curie, Irène
Journal of Cell Death,
Journal of Clinical Oncology,
Journal of the National Cancer Institute,
Judson, Horace Freeland
junk DNA
Jurassic period, 1.1, 1.2, 1.3
Kanam mandible
Kanam West fossil beds
karkinos (crab), in cancer terminology
keratoacanthoma
kidney cancer, 1.1, 7.1, 10.1
Knudson, Alfred G.
kochia
Krebs cycle
Kruszynski, Robert
lactation, 2.1, 10.1
Lancet, The,
Laramide orogeny
Laron syndrome
Laurasia
lead
Leakey, Louis, 3.1, 3.2
Leavitt, Henrietta, 6.1, 13.1, 13.2
le Dran, Henry François
L’Engle, Madeleine
leprosy
leukemia, 1.1, 1.2, 7.1, 9.1, 9.2, 11.1, 13.1
in M. Curie’s death
Levi, Primo, v
Levinson, Arthur D.
lifestyle, cancer risk from, 1.1, 2.1, 7.1, 7.2, 10.1, 11.1, epl.1
light, frequencies of, 2.1, 13.1
Lineweaver, Charles
liquid chromatography
liver, 6.1, 9.1
metastasis to, 3.1, 4.1
liver cancer, 2.1, 5.1, 7.1, 7.2
in trout
London, 10.1, 10.2
longevity, proven cancer risk from, 1.1, 1.2, 2.1, 2.2, 3.1, 7.1, 7.2, 7.3, 7.4, 8.1, 9.1, 10.1, 10.2, 12.1, 13.1, epl.1
Long Island cancer cluster, 2.1, 7.1
Los Alamos, 2.1, 2.2, 7.1
Love, William T.
Love Canal
low-fat diet, dubious benefits of
lumps, discovery of, 2.1
lung cancer, 2.1, 2.2, 2.3, 3.1, 5.1, 5.2, 7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 10.1, 10.2, 10.3, 11.1
incidence of, 7.1, 11.1
radiation and, 11.1, 11.2
lungs, metastasis to, 1.1, 3.1, 3.2, 4.1, 4.2, epl.1
lymphangiogenesis, 4.1, 5.1
lymphatic system, 2.1, 2.2, 3.1, 4.1, 8.1, 11.1, epl.1
as metastatic pathway, 4.1, 5.1, 6.1
lymphedema, 11.1, 11.2
lymphocytes
lymphomas, 1.1, 9.1
Lyndon B. Johnson Space Center
macrophages, 9.1, 10.1
Madame Curie (movie)
Magellanic Clouds
mammograms
screening debate over
March of Dimes
Maret, Nancy (author’s wife), 4.1, 4.2, 11.1
in aftermath of cancer, 13.1, epl.1
childlessness of
healthy lifestyle of, 2.1, 2.2, 2.3, 4.1, 8.1
marriage ended by
Maret, Nancy (author’s wife), cancer of
diagnosis of, 1.1, 2.1, 3.1, 8.1, 9.1, 10.1, 12.1, epl.1
follow-ups to
metastatic route of, 2.1, 3.1, 4.1, 6.1
treatment strategy for, 4.1, 6.1, 8.1, 11.1, 13.1
Massachusetts General Hospital, 12.1, 12.2
mass spectrometry
mastectomies, 2.1, 12.1
Maxwell’s demons, epl.1, epl.2
Mayo Clinic
McLaughlin, Thomas
MD Anderson Cancer Center, 1.1, 2.1, 9.1, 11.1, 12.1
Nancy’s trip to, 8.1, 9.1
mean, median vs.
“Median Isn’t the Message, The” (Gould)
medical practices
cancer risk from
shortcomings of, 2.1, 6.1
triumphs of
see also cancer treatments
medulloblastoma, 6.1, 12.1
melan cholo,
melanoblastoma, 12.1, epl.1
melanoma, 3.1, 5.1, 12.1
cousins in drug study on
rise in, 7.1, 7.2
melatonin
Memorial Sloan-Kettering cancer center, 2.1, 2.2, 7.1
menarche, early age of, 2.1, 7.1, 7.2, 10.1
Mendel, Gregor, 5.1, 12.1
Mendelsohn, John
meningiomas
menopause, 2.1, 3.1, 8.1
menstruation, 2.1, 2.2, 3.1, 7.1, 10.1
mesenchymal cells
mesothelioma, 7.1, 8.1
Mesozoic age (Age of Dinosaurs)
metabolic carcinogenesis
metabolic syndrome
metabolism
in cancer risk, 1.1, 2.1, 10.1
glucose, 10.1, 13.1
pulse rate and life span in
metastasis, 1.1, 1.2, 1.3, 2.1, 3.1, 4.1, 9.1, 9.2, 12.1, 13.1
contagious
EMT in
evolving historical insights on
historical evidence of, 1.1, 3.1, 3.2
modern theory of
in Nancy’s cancer, 2.1, 3.1, 4.1, 6.1
plant propagation compared to
“metastatic affections,” 4.1
metazoans
methylation, 9.1, 13.1
mice, research on, 4.1, 6.1, 7.1, 9.1, 12.1, 12.2
Michor, Franziska, 12.1, 13.1
microbiome
microRNA
microwave radiation, inconclusive threat from
Middle Ages, 3.1, 3.2, 4.1
migrant studies, 7.1, 10.1
Million Women Study
mining
contaminants from
uranium, 5.1, 11.1
miscarriage
mitochondria, 13.1, epl.1
mitogenesis
mitosis, 5.1, 5.2, 7.1, 8.1, 8.2, 9.1, 13.1
electricity and
Model City
monoclonal antibodies, 12.1, epl.1
monoclonal theory
Montagu, Ashley
Morgan, Thomas Hunt
Morrison Formation, 1.1, 1.2, 1.3
mouth cancer, 1.1, 10.1
MRI scans, 11.1, epl.1
Mrs. Trujillo (author’s neighbor)
Mukherjee, Siddhartha
Muller, Hermann J., 5.1, 5.2
Müller, Johannes
multiple myeloma, 1.1, 3.1
multivitamins
mummies
mustard gas, 2.1, 8.1
mustargen (nitrogen mustard)
mutagens
mutations, 2.1, 3.1, 3.2, 3.3, 7.1, 9.1, 9.2, 11.1, 13.1, epl.1
genetic, 5.1, 7.1, 12.1
radiation in
in sheep, 6.1, 12.
1
as subject of developmental biology
mutagenesis
myb gene
myc gene, 5.1, 5.2, 5.3
myeloblastosis
myelocytomatosis
myeloma
“mysterious sympathy,” 10.1, 10.2
Nagasaki
naphthalene
nasopharyngeal carcinoma
National Academy of Sciences
National Breast Cancer Awareness Month, 12.1, 12.2
National Cancer Institute, 2.1, 2.2, 7.1, 7.2, 7.3, 9.1, 9.2, 13.1, 13.2, 13.3, epl.1
National Institutes of Health
National Research Council
National Toxicology Program, 2.1, 7.1, 8.1
Native Americans
Natural History (Pliny)
Natural History Museum, London, 3.1, 3.2
Nature Reviews Cancer,
nausea, 8.1, 8.2, epl.1
necroptosis
needle biopsy
neoplasm, 1.1, 1.2, 1.3, 2.1, 2.2
benign, 1.1, 2.1
Neulasta
neuroblastoma
neurodegenerative diseases
newts, low cancer incidence in
New Yorker, The, 1334
New York Times, The, 8.1, 10.1, 11.1, 12.1
Niagara Falls
nitrosamines
Nixon, Richard
N-nitroso compounds
Nobel Prize, 9.1, 9.2, 11.1
nose, 3.1
“Novel Transcription Factor Involved in Neurogenesis,”
Nowell, Peter, nts.1, nts.2
nuclear accidents
nuclear blasts, 11.1, 13.1, epl.1
nuclear fallout
nuclear magnetic resonance
nuclear power plants, 11.1, 11.2
nucleotides, four-symbol alphabet for, 5.1, 5.2, 9.1, 9.2
nuns, cancer in
Nurses’ Health Study
Oates, Joyce Carol
obesity
and inflammation
proven cancer risk from, 1.1, 2.1, 2.2, 2.3, 7.1, 7.2, 9.1, 9.2, 10.1, 10.2, 10.3, 12.1
occupational exposure, cancer risk from, 10.1, 11.1
Odyssey (Homer)
Office de Protection Contre le Rayonnements Ionisants,
omega-3 fatty acids
“ ’omics,”
Omnis cellula e cellula dictum
oncogenes, 5.1, 5.2, 6.1, 9.1, 9.2, 9.3, 9.4, 12.1
oncologists, 2.1, 2.2, 3.1, 4.1, 8.1, 8.2, 8.3, 11.1, 12.1, 13.1, 13.2
origin of term
On the Nature and Structural Characteristics of Cancer, and of those Morbid Growths which May Be Confounded with It (Müller)
osteoblastic
osteoblastoma
osteolytic
osteomas
osteomyelitis
osteosarcoma, 1.1, 1.2, 3.1, 3.2, 3.3
ovarian cancer, 2.1, 2.2, 2.3, 4.1, 5.1, 8.1, 9.1
ovaries, 1.1, 6.1
oxidative stress
p53 gene, 5.1, epl.1
Pachylebius,
Pacific Islanders
paclitaxel (Taxol), 8.1, 8.2, 8.3, 9.1
Paget, Stephen, 4.1, 4.2