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Connectome

Page 43

by Sebastian Seung


  and connectomes, [>]

  as connectopathies, [>], [>]

  and defects in proteins, [>]

  depression, [>], [>]

  drugs for, [>]–[>] (see also Drugs)

  antidepressants, [>], [>]–[>], [>]–[>]

  development of, [>]–[>], [>]

  for neurodegenerative disorders, [>], [>], [>]

  infectious, [>]–[>], [>]

  investment in therapies for, [>]

  lissencephaly, [>]–[>]

  methods of search for, [>]–[>]

  microcephaly, [>]

  nature vs. nurture in, [>]–[>]

  obsessive-compulsive disorder, [>], [>]

  schizophrenia, [>], [>]–[>], [>], [>] (see also Schizophrenia)

  studies of with animals, [>]–[>]

  studies of from balanced populations, [>]

  syphilis, [>]–[>], [>]

  Tourette’s syndome, [>]

  treatment of

  and connectopathies, [>]

  drugs in, [>]–[>]

  for neurodevelopmental disorders, [>]–[>]

  optimism about, [>]–[>]

  question of abuse of, [>]

  timing in, [>]

  training regimens in, [>]

  See also Brain disorders; Neurodegenerative disorders; Neurodevelopmental disorders

  Merge error, [>]

  Merkle, Ralph, [>]

  Method of loci, [>]

  Methuselah Foundation, [>]

  MGN (medial geniculate nucleus), [>]

  Microbiology, Leeuwenhoek as father of, [>]

  Microcephaly, congenital, [>], [>]

  Microscopic organisms, and microscope, [>]

  Microscopy, [>], [>]

  for connectome exploration, [>]

  of dead brains, [>]

  differential interference contrast (DIC), [>]

  electron, [>]–[>], [>] (see also Electron microscope)

  serial electron, [>]–[>], [>]–[>], [>], [>], [>]

  and Leeuwenhoek, [>]

  light, [>], [>]

  serial, [>]

  transmission electron, [>]

  Microtomes, [>]

  Mind reading, [>]

  Minds

  and connectomes, [>]

  difference in due to connectomes, [>]

  See also Self

  “Mind uploading.” See Computer simulation; “Uploading”

  Minos (king of Crete) and Minotaur, [>], [>]

  Minsky, Marvin, [>]

  Miracles, [>]–[>]

  modern, [>]

  Miswiring, [>], [>]

  Mitchell, Silas Weir, [>]

  Modha, Dharmendra, [>]–[>], [>], [>]

  Molaison, Henry Gustav, [>]

  Monkey cortex

  connections between visual areas of, [>], [>]

  map of, [>], [>]

  Moore, Gordon, [>]

  Moore’s Law, [>], [>], [>]

  Morality, and naturalistic fallacy, [>]

  Morse code as analogy to action potentials, [>]–[>]

  Motor homunculus, [>], [>], [>]

  Motor neurons, [>]

  Mozart, Wolfgang Amadeus, starling as pet of, [>]

  MRC Laboratory for Molecular Biology, Cambridge, England, [>]

  MRI. See Magnetic resonance imaging

  MTL (medial temporal lobe), [>]–[>]

  and memory, [>]–[>]

  Multiple intelligences, [>]

  Multiple sclerosis, [>]

  Muscle fibers, contraction of, [>]

  Muscles, and synaptic inhibition, [>]

  Myelin and myelination, [>]–[>], [>], [>]

  “Myeloarchitecture,” [>]

  Myrdal, Gunnar, [>]

  Myth of Sisyphus, The (Camus), [>]

  “Nanobots,” [>]

  National Institutes of Health (NIH), and Human Connectome Project, [>]

  Nature-nurture relation, [>]–[>]

  in autism and schizophrenia, [>]

  and connectomes, [>]

  and twin studies, [>]–[>]

  Negative feedback, [>]

  Neocognitron, [>]–[>]

  Neocortex, [>], [>], [>]

  double bouquet cell of, [>], [>]

  region comparable to in birds, [>]

  Neocortical plasticity, [>]–[>]

  Neo-phrenologists and neo-phrenology

  and brain size, [>]–[>], [>]

  on memories and learning, [>]–[>], [>], [>], [>], [>]

  and mental retardation, [>]

  Nerves (poultry), axons as, [>]–[>]

  Nervous system, [>]

  Neural code, [>]–[>]

  Neural Darwinism, [>]–[>], [>], [>], [>], [>], [>]

  for adult neurons, [>], [>]

  Neurites, [>]–[>], [>]–[>], [>], [>]

  axons, [>]–[>] (see also Axons)

  dendrites, [>]–[>] (see also Dendrites)

  and synapses, [>]

  three-dimensional rendering of fragments of, [>]

  Neuroanatomy, [>]

  limitations of, [>]–[>]

  Neuroblasts, [>]

  Neurodegenerative disorders

  Alzheimer’s disease, [>], [>], [>], [>], [>]

  drugs for, [>], [>], [>]

  mouse models of, [>]

  Parkinson’s disease, [>]–[>], [>], [>], [>], [>]

  See also Mental disorders and disabilities

  Neurodevelopmental disorders

  autism and schizophrenia as, [>]–[>] (see also Autism; Schizophrenia)

  treatment for

  prevention, [>]–[>]

  through rewiring, [>]

  See also Mental disorders and disabilities

  Neurologists, [>]

  Neuromodulators, [>]–[>]

  Neuronal connectome, [>], [>], [>], [>], [>], [>], [>], [>]

  Neurons, [>], [>]–[>]

  activity of, [>]–[>]

  collective action of, [>]–[>]

  communication between, [>]–[>]

  excitatory and inhibitory synapses and neurons in, [>]–[>]

  and nonspiking neurons, [>]–[>]

  through pathways, [>]–[>]

  and “weighted voting model,” [>]–[>], [>]

  as computing, [>]–[>]

  and connectionism, [>], [>]–[>]

  connections among, [>], [>]

  part-whole rule in, [>]–[>]

  rules of, [>]–[>]

  and connections to outside world, [>]

  creation of, [>], [>]

  in parallel with elimination, [>]–[>]

  question of in adults, [>]

  and Dale’s Principle, [>]

  degeneration and death of, [>], [>]

  elimination of, [>]–[>], [>]–[>]

  excitatory, [>]–[>]

  extrasynaptic interactions of, [>]–[>], [>]

  four R’s in change of, [>], [>]–[>], [>] (see also Reconnection; Regeneration; Reweighting of synapse; Rewiring of brain)

  and genes, [>], [>]

  Golgi staining of, [>]

  image of, [>]

  inhibitory, [>]–[>], [>], [>]

  organization of (dumb into smart), [>]

  in perception, [>]

  previous impossibility of seeing, [>]

  reading of thoughts and perceptions from, [>]

  of retina (reconstructed automatically by computer), [>]

  rules of connection governing, [>]–[>]

  simulations of, [>]

  spiking for specific celebrity, [>]

  and synapses, [>] (see also Synapse)

  technological progress in imaging of, [>]–[>]

  tracing branches of through cross-sections, [>]

  types of, [>], [>]–[>], [>]–[>], [>]–[>], [>]

  and C. elegans, [>]–[>]

  and connectionism, [>]–[>]

  models of, [>]

  pyramidal, [>], [>]–[>], [>]–[>], [>]

  variety of, [>]

  “weighted voting model” of, [>]–[>], [>], [>], [>], [>], [>]

  Neuropathology(ies)
, [>]

  and autism or schizophrenia treatment, [>]

  for diverse genetic defects, [>]

  and drug evaluation, [>]

  Neuroscience and neuroscientists, [>]

  of change, [>]

  and challenge of empirical investigation of connectome, [>]–[>]

  and challenge of overwhelming amounts of information, [>], [>]

  and changing our brains, [>]

  and dilemma of phrenology vs. connectionism, [>]

  and extrasynaptic interactions of neurons, [>]–[>]

  and fashioning of connectome, [>]–[>]

  and four R’s, [>] (see also Reconnection; Regeneration; Reweighting of synapse; Rewiring of brain)

  of future (connectomics), [>]

  vs. “ghost in the machine,” [>]

  “grand challenges” for, [>]

  and great inventions, [>]–[>]

  and hypotheses about memory, [>]–[>]

  and mind vs. brain, [>]

  and self-improvement, [>]

  through simulation, [>]

  stains important in, [>]

  unachieved benefits of, [>]

  understanding brain as goal of, [>]

  and unknown, [>]–[>]

  Neurotransmitter, [>], [>]–[>], [>]–[>], [>], [>], [>]–[>]

  Dale’s Principle on, [>]

  discovery of, [>]–[>]

  surplus or deficiency of in mental disorders, [>]

  New Organon (Bacon), [>]

  Newton, Sir Isaac, [>], [>]

  Nicolelis, Miguel, [>]

  Nicotine, [>]

  and brain function, [>]

  Nissl, Franz, [>]

  Nobel Prize in economics, [>]

  Nondeclarative (implicit) memory, [>]–[>]

  Notebook parable about memory theories, [>]–[>]

  Nottebohm, Fernando, [>]–[>], [>], [>]

  Nucleotides, [>], [>], [>]

  Obsessive-compulsive disorder, [>], [>]

  Occipital lobe, [>]–[>], [>], [>], [>]

  Olfactory bulb, [>], [>]

  Olson, Charles, [>], [>]

  On Memory (Aristotle), [>]–[>]

  Optic nerve, [>]

  Optogenetics, [>]

  Organization of Behavior, The (Hebb), [>]

  “Organology,” [>]

  Organ transplantation, [>]–[>]

  of brain, [>]–[>]

  Pangloss, Dr. (Voltaire character), [>]

  Paparazzi metaphor for perception, [>]–[>]

  Paré, Ambroise, [>]–[>]

  Parietal lobe, [>]–[>], [>]

  learning to juggle as thickening, [>]

  left parietal lobe, [>]

  Parietal lobule, inferior, [>]

  Parkinson’s disease (PD), [>]–[>], [>], [>], [>]

  stem-cell treatment for, [>]

  Pascal, Blaise, [>]

  on immensity of universe, [>]–[>], [>], [>]

  Pascal’s Wager, [>]–[>], [>], [>]

  Pasteur, Louis, [>], [>]

  Patch clamp recording, [>]

  Pathways, [>]–[>]

  and neural voting, [>]–[>]

  and nonspiking neurons, [>]–[>]

  Pearson, Karl, [>]

  Pearson’s correlation coefficient, [>]

  Penfield, Wilder, [>], [>]–[>]

  Penicillin, discovery of, [>]

  Pensées (Pascal), [>], [>]

  Perception

  association in, [>] (see also Association)

  through collection of specific functions, [>]–[>]

  hierarchical organization of, [>]–[>], [>]–[>]

  and neural code, [>]–[>]

  “grandmother cell” theory of, [>]

  machines incapable of (Leibniz), [>]

  memory compared with, [>]

  and MTL, [>]

  neuron functions in, [>]

  Plato on (wax metaphor), [>]

  spiking provides picture of, [>]

  Perceptron, [>], [>], [>], [>]

  Peripheral nervous system (PNS), [>]

  Peters’ Rule, [>]

  Phantom limb, [>], [>]–[>]

  and rewiring, [>]

  Phaedrus (Plato), [>]

  Pharmaceutical industry

  and drug development, [>]

  as Ehrlich’s invention, [>]

  Phencyclidine (PCP), [>]

  Phenothiazines, [>], [>]

  Pheromone, [>]

  Philosophical Transactions of the Royal Society of London, [>]

  Photoreceptors, [>], [>]–[>]

  Phrenological map, [>]

  Phrenology and phrenologists, [>], [>], [>], [>]

  and factory analogy, [>]

  need to imrove on, [>]

  and study of cortical plasticity, [>]

  Piltdown Man, [>]

  Plasticity, [>], [>]

  cortical, [>]

  “cross-modal,” [>]

  rule of, [>]–[>]

  vs. stability, [>]

  Plastination, [>], [>]–[>]

  Plato

  carving metaphor of, [>], [>]

  on memory, [>], [>]

  Plum, Fred, [>]

  Pompeii, discovery of, [>]–[>]

  Ponce de León, Juan, [>]

  Pony Express, [>]–[>]

  Pope, Alexander, [>]

  Porter, Keith, [>]

  Posterior hippocampus, [>]

  Postsynaptic density, [>]

  Primary visual cortex (V1), [>], [>], [>]

  Probability

  and Pascal’s Wager, [>]–[>]

  and rational decision-making, [>]

  and reanimation issues, [>]–[>]

  “Problem of Serial Order in Behavior, The” (Lashley), [>]

  Profound Hypothermia and Circulatory Arrest (PHCA) (procedure), [>]

  Prospect of Immortality, The (Ettinger), [>]

  Proteins, [>], [>]–[>], [>]

  and genes, [>], [>]

  ion channels, [>]

  and Parkinson’s disease, [>]

 

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